| 1 | ORBIMED ADVISORS LLC OrbiMed Capital GP VII LLC OrbiMed Genesis GP LLC Director 10% Owner | 2026-07-20 21:32:47 | 4,127,987 0 | 4,127,987 | Form 13D |
| 2 | Flynn James E DEERFIELD MANAGEMENT COMPANY L.P. (SERIES C) Deerfield Mgmt L.P. DEERFIELD PARTNERS L.P. Deerfield Private Design Fund III L.P. Deerfield Mgmt III L.P. Deerfield Healthcare Innovations Fund L.P. Deerfield Mgmt HIF L.P. Possible Member of 10% Group 10% Owner | 2020-05-01 08:31:18 | 2,254,567 0 | 2,254,567 | Form 13D |
| 3 | Novartis Institutes for BioMedical Research Inc. NOVARTIS AG 10% Owner | 2020-03-10 12:20:08 | 1,979,226 0 | 1,979,226 | Form 13G |
| 4 | SHAH MAHENDRA Director | 2018-05-16 16:05:25 | 0 909,742 | 909,742 | Form 4/A |
| 5 | Atlas Venture Fund X L.P. ATLAS VENTURE ASSOCIATES X L.P. Atlas Venture Associates X LLC Atlas Venture Opportunity Fund I L.P. Atlas Venture Associates Opportunity I L.P. Atlas Venture Associates Opportunity I LLC Atlas Venture Opportunity Fund II L.P. Atlas Venture Associates Opportunity II LP Atlas Venture Associates Opportunity II LLC 10% Owner | 2026-05-28 16:28:47 | 864,261 0 | 864,261 | Form 13D |
| 6 | Vida Ventures LLC VV Manager LLC 10% Owner | 2018-04-04 16:24:00 | 0 770,845 | 770,845 | Form 4 |
| 7 | Rock Springs Capital Management LP Rock Springs Capital Master Fund LP Rock Springs Capital LLC 10% Owner | 2018-04-04 16:24:07 | 0 645,845 | 645,845 | Form 4 |
| 8 | Atlas Venture Opportunity Fund Ill L.P. Atlas Venture Associates Opportunity III L.P. Atlas Venture Associates Opportunity III LLC See Remarks | 2026-06-08 16:30:23 | 625,000 0 | 625,000 | Form 3 |
| 9 | Chatterjee Saswati 10% Owner | 2018-03-27 18:02:57 | 475,014 0 | 475,014 | Form 3 |
| 10 | Morrison Jodie Pope CEO | 2026-10-14 17:30:05 | 340,038 0 | 340,038 | Form 4 |
| 11 | Temasek Holdings (Private) Ltd Fullerton Management Pte Ltd Temasek Life Sciences Private Ltd TLS Beta Pte. Ltd. V-Sciences Investments Pte Ltd 10% Owner | 2024-10-25 06:06:25 | 313,943 0 | 313,943 | Form 13G |
| 12 | Smith W Bradford See remarks | 2023-02-27 16:05:27 | 249,000 0 | 249,000 | Form 4 |
| 13 | Rasty Siyamak Chief Operating Officer | 2019-07-11 16:30:42 | 222,707 0 | 222,707 | Form 4 |
| 14 | Campagna Jason Chief Medical Officer | 2025-02-26 21:57:04 | 213,876 0 | 213,876 | Form 4 |
| 15 | Violette Shelia M. Chief Scientific Officer | 2026-10-14 17:30:03 | 126,854 36,277 | 163,131 | Form 4 |
| 16 | Seymour Albert See Remarks | 2023-09-08 16:44:26 | 160,254 0 | 160,254 | Form 4 |
| 17 | Kalowski Lee CFO and President | 2026-10-14 17:30:03 | 137,170 0 | 137,170 | Form 4 |
| 18 | Blum Michael Lee Chief Commercial Officer | 2023-02-27 16:05:45 | 121,000 0 | 121,000 | Form 4 |
| 19 | Kelly Timothy P Chief Operating Officer | 2022-02-28 16:05:55 | 33,000 0 | 33,000 | Form 4 |
| 20 | GILLIS STEVEN Director | 2023-06-15 19:25:26 | 23,000 0 | 23,000 | Form 4 |
| 21 | Patterson Matthew R Director | 2023-06-15 18:33:36 | 23,000 0 | 23,000 | Form 4 |
| 22 | Poulton Jeffrey V. Director | 2023-06-15 18:09:39 | 23,000 0 | 23,000 | Form 4 |
| 23 | REICIN ALISE Director | 2023-06-15 18:04:26 | 23,000 0 | 23,000 | Form 4 |
| 24 | Gregory Richard J. Director | 2022-06-17 16:05:48 | 18,000 0 | 18,000 | Form 4 |
| 25 | PARMAR KUSH Director | 2022-06-17 16:05:20 | 18,000 0 | 18,000 | Form 4 |
| 26 | Wheeler Cameron Director | 2019-06-11 19:33:33 | 0 15,580 | 15,580 | Form 4/A |
| 27 | Cohn Gabriel Chief Medical Officer | 2022-01-12 16:05:24 | 11,339 0 | 11,339 | Form 4 |
| 28 | Thistle Mary Director | 2026-07-21 20:22:44 | 10,826 0 | 10,826 | Form 4/A |
| 29 | GRAYZEL DAVID S. Director | 2026-07-21 20:24:19 | 10,826 0 | 10,826 | Form 4/A |
| 30 | Manke Isaac Director | 2026-07-21 20:25:05 | 10,826 0 | 10,826 | Form 4/A |
| 31 | Xu Diyong Director 10% Owner | 2026-07-21 20:25:41 | 10,826 0 | 10,826 | Form 4/A |
| 32 | Iwicki Mark T Director | 2026-07-21 20:37:32 | 10,826 0 | 10,826 | Form 4/A |
| 33 | LAPORTE KATHLEEN Director | 2026-07-21 20:39:23 | 10,826 0 | 10,826 | Form 4/A |
| 34 | Lundberg Sven Ante Director | 2026-07-21 20:39:32 | 10,826 0 | 10,826 | Form 4/A |
| 35 | TZIANABOS ARTHUR Director | 2026-07-21 20:40:28 | 10,826 0 | 10,826 | Form 4/A |
| 36 | Jordan Julie Chief Medical Officer | 2023-08-07 21:39:25 | 7,496 0 | 7,496 | Form 4 |
| 37 | Alloway Paul See Remarks | 2024-04-23 17:03:07 | 2,596 0 | 2,596 | Form 4 |
| 38 | Michaud Charles Jr See Remarks | 2024-04-23 17:00:03 | 927 0 | 927 | Form 4 |
| 39 | 5AM Ventures IV L.P. 5AM Co-Investors IV L.P. 5AM Partners IV LLC DIEKMAN JOHN D ROCKLAGE SCOTT M Schwab Andrew J. 10% Owner | 2024-11-14 17:46:10 | 0 0 | 0 | Form 13G |
| 40 | ARCH Venture Fund VIII L.P. ARCH Venture Fund VIII Overage L.P. ARCH Venture Partners VIII L.P. ARCH Venture Partners VIII LLC BYBEE CLINTON CRANDELL KEITH NELSEN ROBERT 10% Owner | 2024-05-13 17:34:55 | 0 0 | 0 | Form 13G |