| 1 | Longitude Capital Partners III LLC Longitude Venture Partners III L.P. Tammenoms Bakker Juliet ENRIGHT PATRICK G 10% Owner | 2023-02-14 16:18:55 | 1,233,399 0 | 1,233,399 | Form 13D |
| 2 | Kariv Tomer Pontifax (Israel) V L.P. Pontifax (Cayman) V L.P. Pontifax (China) V L.P. Pontifax 5 G.P. L.P. Pontifax Management 4 G.P. (2015) Ltd. Pontifax Late Stage GP Ltd. Pontifax Late Stage Fund L.P. Director 10% Owner | 2019-11-13 19:10:44 | 0 1,134,671 | 1,134,671 | Form 4 |
| 3 | Waisbourd Ram See Remarks | 2022-02-22 17:13:20 | 33,750 0 | 33,750 | Form 4 |
| 4 | Grunberg Gregory Director 10% Owner | 2023-02-13 17:34:51 | 27,400 0 | 27,400 | Form 4 |
| 5 | Naschitz Anat Director 10% Owner | 2021-04-19 16:46:49 | 0 12,500 | 12,500 | Form 4 |
| 6 | RA CAPITAL MANAGEMENT L.P. RA Capital Healthcare Fund LP RA Capital Nexus Fund L.P. Kolchinsky Peter Shah Rajeev M. Director 10% Owner | 2025-11-03 16:42:43 | 0 0 | 0 | Form 13D |
| 7 | LAPORTE KATHLEEN Director | 2025-10-30 20:33:57 | 0 0 | 0 | Form 4 |
| 8 | Hayden Michael R Director | 2025-10-30 20:31:14 | 0 0 | 0 | Form 4 |
| 9 | Martins Ryan Chief Financial Officer | 2025-10-30 20:28:17 | 0 0 | 0 | Form 4 |
| 10 | Altschuler Steven Director | 2025-10-30 20:25:11 | 0 0 | 0 | Form 4 |
| 11 | PALEKAR ROHAN Chief Executive Officer | 2025-10-30 20:22:58 | 0 0 | 0 | Form 4 |
| 12 | McWherter Charles Director | 2025-10-30 20:22:20 | 0 0 | 0 | Form 4 |
| 13 | Atkinson Edward Morrow III Director | 2025-10-30 20:19:31 | 0 0 | 0 | Form 4 |
| 14 | Zoth Lota S. Director | 2025-10-30 20:18:47 | 0 0 | 0 | Form 4 |
| 15 | Le-Nguyen Quoc See Remarks | 2025-10-30 20:18:21 | 0 0 | 0 | Form 4 |
| 16 | Babler Martin Director | 2025-10-30 20:14:01 | 0 0 | 0 | Form 4 |
| 17 | DiRocco Derek Director | 2025-10-30 20:11:51 | 0 0 | 0 | Form 4 |
| 18 | Sarena Francis Willard Chief Operating Officer | 2025-10-30 20:10:56 | 0 0 | 0 | Form 4 |
| 19 | Mansbach Harry H Chief Medical Officer | 2025-10-30 20:10:12 | 0 0 | 0 | Form 4 |
| 20 | ORBIMED ADVISORS LLC OrbiMed Capital GP VI LLC OrbiMed Advisors Israel II Ltd OrbiMed Israel GP II L.P. 10% Owner | 2023-03-24 16:43:06 | 0 0 | 0 | Form 13D |