Sec Form 4 Filing - Kariv Tomer @ 89bio, Inc. - 2019-11-11

FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person Kariv Tomer 2. Issuer Name and Ticker or Trading Symbol 89bio, Inc. [ ETNB] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) X __ Director X __ 10% Owner _____ Officer (give title below) _____ Other (specify below) (Last) (First) (Middle) 14 SHENKAR STREET, BEIT OFEK 3. Date of Earliest Transaction (MM/DD/YY) 11/11/2019 (Street) HERZLIYA PITUACH, L3L3 46140 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) _____ Form filed by One Reporting Person __ X __ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 11/11/2019 P 250,000 ( 1 ) A $ 16 250,000 I See footnotes ( 3 ) ( 6 ) ( 7 ) Common Stock 11/13/2019 C 884,671 A 1,134,671 I See footnotes ( 4 ) ( 6 ) ( 7 )

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares Series A Preferred Stock ( 2 ) 11/13/2019 C 5,500,001 ( 2 ) ( 2 ) Common Stock 884,671 $ 0 0 I See footnotes ( 5 ) ( 6 ) ( 7 )

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other Kariv Tomer 14 SHENKAR STREET, BEIT OFEK HERZLIYA PITUACH, L3L3 46140 X X Pontifax (Israel) V, L.P. 14 SHENKAR STREET, BEIT OFEK HERZLIYA PITUACH, L3L3 46140 X Pontifax (Cayman) V, L.P. 14 SHENKAR STREET, BEIT OFEK HERZLIYA PITUACH, L3L3 46140 X Pontifax (China) V, L.P. 14 SHENKAR STREET, BEIT OFEK HERZLIYA PITUACH, L3L3 46140 X Pontifax 5 G.P. L.P. 14 SHENKAR STREET, BEIT OFEK HERZLIYA PITUACH, L3L3 46140 X Pontifax Management 4 G.P. (2015) Ltd. 14 SHENKAR STREET, BEIT OFEK HERZLIYA PITUACH, L3L3 46140 X Pontifax Late Stage GP Ltd. 14 SHENKAR STREET, BEIT OFEK HERZLIYA PITUACH, L3L3 46140 X Pontifax Late Stage Fund L.P. 14 SHENKAR STREET, BEIT OFEK HERZLIYA PITUACH, L3L3 46140 X Signatures /s/ Tomer Kariv 11/13/2019 Signature of Reporting Person Date Pontifax (Israel) V, L.P.; By /s/ Tomer Kariv, Chief Executive Officer 11/13/2019 Signature of Reporting Person Date Pontifax (Cayman) V, L.P.; By /s/ Tomer Kariv, Chief Executive Officer 11/13/2019 Signature of Reporting Person Date Pontifax (China) V, L.P.; By /s/ Tomer Kariv, Chief Executive Officer 11/13/2019 Signature of Reporting Person Date Pontifax 5 G.P. L.P.; By /s/ Tomer Kariv, Chief Executive Officer 11/13/2019 Signature of Reporting Person Date Pontifax Management 4 G.P. (2015) Ltd.; By /s/ Tomer Kariv, Chief Executive Officer 11/13/2019 Signature of Reporting Person Date Pontifax Late Stage GP Ltd.; By /s/ Tomer Kariv, Authorized Signatory 11/13/2019 Signature of Reporting Person Date Pontifax Late Stage Fund L.P.; By /s/ Tomer Kariv, Authorized Signatory 11/13/2019 Signature of Reporting Person Date

Explanation of Responses:

( 1 )On November 11, 2019, Pontifax (Israel) V, L.P. purchased 134,390 shares of the Issuer's common stock, Pontifax (Cayman) V, L.P. purchased 35,897 shares of the Issuer's common stock, Pontifax (China) V, L.P. (collectively, the "Pontifax Entities") purchased 52,213 shares of the Issuer's common stock and Pontifax Late Stage Fund L.P. ("Late Stage L.P.") purchased 27,500 shares of the Issuer's common stock at a price of $16.00 per share in the Issuer's initial public offering. ( 2 )The Series A Preferred Stock automatically converted into shares of the Issuer's common stock on a one-for-6.217 basis immediately prior the closing of the Issuer's initial public offering on November 13, 2019 and had no expiration date. ( 3 )Includes (a) 134,390 shares held by Pontifax (Israel) V, L.P., (b) 35,897 shares held by Pontifax (Cayman) V, L.P., (c) 52,213 shares held by Pontifax (China) V, L.P. and (d) 27,500 shares held by Late Stage L.P. ( 4 )Includes (a) 668,732 shares held by Pontifax (Israel) V, L.P., (b) 178,623 shares held by Pontifax (Cayman) V, L.P., (c) 259,816 shares held by Pontifax (China) V, L.P. and (d) 27,500 shares held by Late Stage L.P. ( 5 )Includes (a) 534,342 shares held by Pontifax (Israel) V, L.P., (b) 142,726 shares held by Pontifax (Cayman) V, L.P. and (c) 207,603 shares held by Pontifax (China) V, L.P. ( 6 )Pontifax 5 G.P. L.P. ("Pontifax 5 GP") is the general partner of each of the Pontifax Entities, and Pontifax Management 4 G.P. (2015) Ltd. ("Pontifax Management") is the general partner of Pontifax 5 GP. Mr. Tomer Kariv is one of two Managing Partners of Pontifax Management and, as a result, may be deemed to share voting and investment power with respect to the shares held by each of the Pontifax Entities. Mr. Kariv disclaims beneficial ownership of those shares held by the Pontifax Entities, except to the extent of his pecuniary interest therein. Late Stage L.P. invests side by side with Pontifax 5 GP pursuant to a Strategic Alliance Agreement with Pontifax 5 GP. Pontifax Late Stage GP Ltd. ("Late Stage GP") is the general partner of Late Stage L.P. ( 7 )(Continued from footnote 6) and the sole shareholder of Late Stage GP is Mr. Shlomo Karako. By virtue of the strategic relationship, each of Pontifax 5 GP, Pontifax Management, Ran Nussbaum, and Tomer Kariv may be deemed to share voting and dispositive power with respect to the shares held by Late Stage L.P. in a manner similar to the voting and investment power with respect to the shares held by each of the Pontifax Entities. In that context, Mr. Kariv disclaims beneficial ownership of such shares, and the inclusion of the shares in this report shall not be deemed to be an admission of beneficial ownership of the reported shares for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise.

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