List of insiders holdings for IONIS PHARMACEUTICALS INC:
  1. Shares directly owned by the insider.
  2. Shares indirectly owned by the insider.
  3. Total shares owned by the insider (sum of shares directly and indirectly owned).
  4. Total market value if available.
  5. Shares are not adjusted for stock split.
"Insiders might sell their shares for any number of reasons, but they buy them for only one: they think the price will rise"
- Peter Lynch
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Insider Holder NameReport
Date Time		Shares Owned
Directly
Indirectly		Total
Shares Owned		Filing
LILLY ELI & CO
10% Owner		2006-02-06 16:40:312,500,000
0		2,500,000Form 13G
CROOKE STANLEY T
Exec Chairman of the Board		2021-01-28 19:22:032021
497,502		499,523Form 4
BERTHELSEN SPENCER R
Director		2022-07-19 19:19:37145,782
70		145,852Form 4
Monia Brett P
Chief Executive Officer		2023-02-07 17:36:55145,305
0		145,305Form 4
WENDER JOSEPH H
Director		2022-07-19 19:21:5416,885
104,969		121,854Form 4
PARSHALL B LYNNE
Director		2022-07-19 19:21:35102,363
0		102,363Form 4
JONAS JEFFREY M
Executive Vice President		2008-01-04 21:27:4678,936
0		78,936Form 4
MUTO FREDERICK T
Director		2022-07-19 19:21:2376,482
1500		77,982Form 4
HOUGEN ELIZABETH L
EVP Finance & CFO		2023-02-07 17:36:4375,496
0		75,496Form 4
Geary Richard S
EVP Chief Development Officer		2023-02-07 17:36:3572,385
0		72,385Form 4
BENNETT C FRANK
EVP Chief Scientific Officer		2023-02-07 17:36:0469,651
0		69,651Form 4
XANTHOPOULOS KLEANTHIS G
President of Regulus		2007-12-05 17:42:5560,000
0		60,000Form 4
LOSCALZO JOSEPH
Director
Director		2022-07-19 19:21:0850,857
0		50,857Form 4
HERMAN JOAN E
Director		2022-07-19 19:20:4649,772
0		49,772Form 4
Castleman Breaux
Director		2020-07-06 17:30:5344,291
0		44,291Form 4
Wedel Mark K
VP & Chief Medical Officer		2007-07-10 18:21:0442,410
0		42,410Form 4
O'NEIL PATRICK R.
EVP CLO & General Counsel		2023-02-07 17:37:0741,581
0		41,581Form 4
ECKER DAVID J
Vice President		2008-09-03 17:57:3712,640
28,713		41,353Form 4
Treble Michael J
Vice President Pres of Ibis		2008-08-13 18:49:1332,500
0		32,500Form 4
Boyce Sarah
Chief Business Officer		2018-01-17 21:23:5732,274
0		32,274Form 4
Swayze Eric
EVP Research		2023-02-07 17:37:4931,941
0		31,941Form 4
COLE DOUGLAS L
Vice President		2004-03-09 18:06:3831,616
0		31,616Form 4
Hayden Michael R
Director		2022-10-18 19:10:4430,219
0		30,219Form 4
LEVIN ARTHUR A
Vice President		2007-04-27 19:44:1825,377
0		25,377Form 4
Schneider Eugene
EVP Chf Clinical Develop Ofcr		2023-02-07 17:37:3024,946
0		24,946Form 4
Reikes Peter N
Director		2021-10-19 18:29:2624,886
0		24,886Form 4
KLEIN JOSEPH III
Director		2023-01-18 20:19:0916,791
6100		22,891Form 4
Cadoret-Manier Onaiza
EVP Chf GL Pdt Str & Oper Ofc		2023-02-07 17:36:2421,227
0		21,227Form 4
MCNEIL JOHN A
Vice President		2005-01-04 17:57:5918,158
0		18,158Form 4
LOWENSTAM PATRICIA
Vice President		2005-01-04 17:52:2218,158
0		18,158Form 4
DiMarchi Richard D
Director		2010-07-02 14:29:1115,000
0		15,000Form 4
LUNDSTEDT KAREN S
Vice President		2004-03-12 17:59:3214,407
0		14,407Form 4
Diaz Allene M.
Director		2022-07-19 19:20:1713,333
0		13,333Form 4
McDevitt Damien
Chief Business Officer		2019-07-17 17:39:1113,198
0		13,198Form 4
GABRIELI CHRISTOPHER
Director		2005-07-06 18:46:2510000
0		10000Form 4
SKALETSKY MARK B
Director		2004-07-02 17:18:5110000
0		10000Form 4
Baroldi Joseph
EVP Chief Business Officer		2023-01-19 20:19:053613
4813		8426Form 4
HOLMLUND JON T
Vice President		2004-02-11 18:47:091966
5593		7559Form 4/A
BROWN RICHARD K
Vice President		2006-03-09 18:32:025118
0		5118Form 4
REED JOHN C
Director		2012-09-06 21:39:454900
0		4900Form 4
STEIN ARON
Vice President		2004-07-02 17:25:542136
0		2136Form 4
DE HAAN HANS A
VP Drug Development		2004-05-05 16:07:370
0		0Form 4