| 1 | JDRF T1D Fund LLC 10% Owner | 2020-07-21 19:45:19 | 426,333 0 | 426,333 | Form 4 |
| 2 | Mutz Mitchell Director 10% Owner | 2020-07-23 16:49:25 | 0 10,000 | 10,000 | Form 4 |
| 3 | Carroll Jill Director 10% Owner | 2021-04-01 19:43:31 | 0 0 | 0 | Form 4 |
| 4 | Viney Joanne L. See Remarks | 2021-04-01 19:59:21 | 0 0 | 0 | Form 4 |
| 5 | Goyal Vikas See Remarks | 2021-04-01 19:58:39 | 0 0 | 0 | Form 4 |
| 6 | Crane Alan L Director 10% Owner | 2021-04-01 19:57:32 | 0 0 | 0 | Form 4 |
| 7 | Freedman Edward D. Chief Operating Officer | 2021-04-01 19:55:34 | 0 0 | 0 | Form 4 |
| 8 | BELOFF GREGG See Remarks | 2021-04-01 19:53:42 | 0 0 | 0 | Form 4 |
| 9 | Kakkar Rahul Chief Executive Officer | 2021-04-01 19:50:04 | 0 0 | 0 | Form 4 |
| 10 | Fuglesang Christopher Director 10% Owner | 2021-04-01 19:49:41 | 0 0 | 0 | Form 4 |
| 11 | Becker Daniel J. Director | 2021-04-01 19:49:34 | 0 0 | 0 | Form 4 |
| 12 | Sundy John Chief Medical Officer | 2021-04-01 19:46:47 | 0 0 | 0 | Form 4 |
| 13 | Stagliano Nancy Director | 2021-04-01 19:46:19 | 0 0 | 0 | Form 4 |
| 14 | Dorton Katina Director | 2021-04-01 19:45:30 | 0 0 | 0 | Form 4 |
| 15 | Frail Donald Director | 2021-04-01 19:45:13 | 0 0 | 0 | Form 4 |
| 16 | ORBIMED ADVISORS LLC OrbiMed Capital GP VII LLC OrbiMed Genesis GP LLC 10% Owner | 2022-02-11 16:39:00 | 0 0 | 0 | Form 13G |
| 17 | Carlo Rizzuto Director | 2021-04-01 19:38:56 | 0 0 | 0 | Form 4 |
| 18 | Larson Eric D Vice President, Finance | 2021-04-01 19:37:59 | 0 0 | 0 | Form 4 |
| 19 | Merck & Co. Inc. MERCK SHARP & DOHME CORP. 10% Owner | 2021-03-04 06:06:59 | 0 0 | 0 | Form 13D |
| 20 | ROCHE HOLDING LTD ROCHE FINANCE LTD 10% Owner | 2021-02-16 07:02:33 | 0 0 | 0 | Form 13G |
| 21 | RA CAPITAL MANAGEMENT L.P. Kolchinsky Peter Shah Rajeev M. 10% Owner | 2021-05-17 16:35:46 | 0 0 | 0 | Form 13G |
| 22 | GLAXOSMITHKLINE PLC Director 10% Owner | 2021-04-08 17:24:29 | 0 0 | 0 | Form 13D |
| 23 | Polaris Partners GP VIII L.L.C. Polaris Entrepreneurs' Fund VIII L.P. Polaris Partners VIII L.P. 10% Owner | 2021-02-12 17:16:00 | 0 0 | 0 | Form 13G |
| 24 | Boxer Capital LLC Boxer Asset Management Inc. Braslyn Ltd. LEWIS JOSEPH Davis Aaron I. MVA Investors LLC 10% Owner | 2020-07-29 21:05:49 | 0 0 | 0 | Form 13D |
| 25 | Versant Venture Capital VI L.P. Versant Vantage I L.P. Versant Ventures VI GP L.P. Versant Ventures VI GP-GP LLC Versant Vantage I GP L.P. Versant Vantage I GP-GP LLC 10% Owner | 2020-07-31 16:26:52 | 0 0 | 0 | Form 13G |
| 26 | Access Industries Holdings LLC AI Pan LLC ACCESS INDUSTRIES MANAGEMENT LLC Blavatnik Len 10% Owner | 2021-02-16 06:20:31 | 0 0 | 0 | Form 13G |