| 1 | Fletcher Aaron G.L. BIOS Capital Management LP BIOS Advisors GP LLC BIOS Fund III LP BIOS Fund III QP LP BIOS Fund III NT LP BIOS Actuate Co-Invest I LP BIOS Actuate Co-Invest II LP Bios Actuate Co-Invest III LP BIOS Equity Partners III LP Director 10% Owner | 2025-06-30 13:01:13 | 0 10,267,884 | 10,267,884 | Form 4 |
| 2 | Kreis Leslie W. Cavu Advisors LLC Cavu Management LP BIOS Fund I LP BIOS Fund I QP LP Bios Equity Partners LP BIOS Fund II LP BIOS Fund II NT LP BIOS Fund II QP LP Bios Equity Partners II LP Director 10% Owner | 2025-06-30 13:02:42 | 0 10,267,884 | 10,267,884 | Form 4 |
| 3 | Bios Equity COF LP Bios Clinical Opportunity Fund LP Bios 2024 Co-Invest LP BP Directors LP Director 10% Owner | 2025-06-30 13:03:52 | 0 10,267,884 | 10,267,884 | Form 4 |
| 4 | BIOS Fund I LP Bios 2024 Co-Invest LP BIOS Actuate Co-Invest I LP BIOS Actuate Co-Invest II LP Bios Actuate Co-Invest III LP Bios Clinical Opportunity Fund LP BIOS Fund I QP LP BIOS Fund II NT LP BIOS Fund II QP LP BIOS Fund II LP Director 10% Owner | 2026-10-30 15:37:14 | 0 3,000,000 | 3,000,000 | Form 4 |
| 5 | BIOS Fund III LP BIOS Fund III QP LP BIOS Fund III NT LP Director 10% Owner | 2026-10-30 17:05:22 | 0 3,000,000 | 3,000,000 | Form 4 |
| 6 | SCHMITT DANIEL M President, CEO and Director | 2026-10-29 09:35:58 | 512,982 630,740 | 1,143,722 | Form 4 |
| 7 | THOMSON TODD S Kairos Venture Partners II L.P. Kairos Venture Opportunities I L.P. Kairos SPV Fund LLC Kairos-Actuate SPV L.P. Kairos Venture Investments LLC DEMETRIADES JAMES T Director | 2026-11-02 16:27:12 | 0 700,000 | 700,000 | Form 4 |
| 8 | LYTLE PAUL J Chief Financial Officer | 2026-04-01 17:19:11 | 105,000 0 | 105,000 | Form 4 |
| 9 | Mazar Andrew Paul Chief Operating Officer | 2026-04-01 17:19:31 | 105,000 0 | 105,000 | Form 4 |
| 10 | Fletcher Aaron G.L. Director 10% Owner | 2026-05-22 16:02:24 | 15,000 0 | 15,000 | Form 4 |
| 11 | Huber Martin H. Jr. Director | 2026-05-22 16:03:42 | 15,000 0 | 15,000 | Form 4 |
| 12 | Keyes Jason A Director | 2026-05-22 16:04:58 | 15,000 0 | 15,000 | Form 4 |
| 13 | RONNEBERG AMY L Director | 2026-05-22 16:09:49 | 15,000 0 | 15,000 | Form 4 |
| 14 | Sawhney Roger Director | 2026-05-22 16:10:59 | 15,000 0 | 15,000 | Form 4 |
| 15 | Zabrowski Dan Director | 2026-05-22 16:15:21 | 15,000 0 | 15,000 | Form 4 |