| 1 | Viswanathan Ravi NEA Partners 14 L.P. NEA 14 GP LTD 10% Owner | 2018-03-27 16:54:01 | 0 4,173,967 | 4,173,967 | Form 4 |
| 2 | Sonsini Peter W. NEA Partners 14 L.P. NEA 14 GP LTD 10% Owner | 2018-03-27 16:53:34 | 0 4,173,967 | 4,173,967 | Form 4 |
| 3 | SANDELL SCOTT D NEA Partners 14 L.P. NEA 14 GP LTD 10% Owner | 2018-03-27 16:53:10 | 0 4,173,967 | 4,173,967 | Form 4 |
| 4 | MOTT DAVID M NEA Partners 14 L.P. NEA 14 GP LTD 10% Owner | 2018-03-27 16:52:43 | 0 4,173,967 | 4,173,967 | Form 4 |
| 5 | KERINS PATRICK J NEA Partners 14 L.P. NEA 14 GP LTD 10% Owner | 2018-03-27 16:52:18 | 0 4,173,967 | 4,173,967 | Form 4 |
| 6 | Florence Anthony A. Jr. NEA Partners 14 L.P. NEA 14 GP LTD 10% Owner | 2018-03-27 16:51:52 | 0 4,173,967 | 4,173,967 | Form 4 |
| 7 | BARRETT M JAMES NEA Partners 14 L.P. NEA 14 GP LTD 10% Owner | 2018-03-27 16:50:11 | 0 4,173,967 | 4,173,967 | Form 4 |
| 8 | BARRIS PETER J NEA Partners 14 L.P. NEA 14 GP LTD 10% Owner | 2018-03-27 16:51:01 | 0 4,173,967 | 4,173,967 | Form 4 |
| 9 | BASKETT FOREST NEA Partners 14 L.P. NEA 14 GP LTD 10% Owner | 2018-03-27 16:51:26 | 0 4,173,967 | 4,173,967 | Form 4 |
| 10 | KOLLURI KRISHNA KITTU 10% Owner | 2016-11-29 17:58:25 | 0 2,758,039 | 2,758,039 | Form 4 |
| 11 | DRANT RYAN D 10% Owner | 2015-02-05 15:55:27 | 0 1,888,474 | 1,888,474 | Form 4 |
| 12 | Weller Harry R 10% Owner | 2015-02-05 15:57:59 | 0 1,888,474 | 1,888,474 | Form 4 |
| 13 | Brookline Tracon Investment Fund II LLC BROOKLINE TRACON INVESTMENT FUND LLC CSA Biotechnology Fund I llc CSA Biotechnology Fund II LLC 10% Owner | 2015-12-21 20:08:47 | 657,552 580,050 | 1,237,602 | Form 4 |
| 14 | THEUER CHARLES PRESIDENT AND CEO | 2024-03-13 17:56:13 | 924,717 0 | 924,717 | Form 4 |
| 15 | JAFCO Super V3 Investment Limited Partnership 10% Owner | 2018-02-13 08:21:49 | 787,774 0 | 787,774 | Form 13G |
| 16 | Brown Scott B. CHIEF FINANCIAL OFFICER | 2024-03-13 17:59:38 | 249,928 0 | 249,928 | Form 4 |
| 17 | Ikarian Capital LLC Ikarian Healthcare Master Fund L.P. Ikarian Healthcare Fund GP L.P. Chart Westcott Living Trust Shahrestani Neil Member of 10% Group 10% Owner | 2024-11-14 20:51:58 | 133,404 0 | 133,404 | Form 13G |
| 18 | Adams Bonne J. Chief Operating Officer | 2023-02-09 21:31:55 | 99,000 0 | 99,000 | Form 4 |
| 19 | BITAR PATRICIA L CFO | 2018-02-23 19:02:45 | 95,000 0 | 95,000 | Form 4 |
| 20 | WIGGINS MARK C Chief Business Officer | 2022-02-01 17:00:31 | 80,000 0 | 80,000 | Form 4 |
| 21 | Puissance Cross-Border Opportunities V LLC Puissance Cross-Border Opportunities IV LLC Puissance Life Science Opportunities Fund VI Puissance Capital Management LP Puissance Capital Management (GP) LLC Puissance Capital Fund (GP) LLC Wang Theodore T 10% Owner | 2020-02-13 20:30:52 | 76,048 0 | 76,048 | Form 13D |
| 22 | Puissance Cross-Border Opportunities V LLC Puissance Cross-Border Opportunities IV LLC Puissance Capital Management LP Puissance Capital Fund (GP) LLC Puissance Capital Management (GP) LLC Wang Theodore T 10% Owner | 2020-02-13 20:30:52 | 76,048 0 | 76,048 | Form 13D |
| 23 | LOGAN H CASEY Chief Business Officer | 2018-01-23 19:12:41 | 27,754 0 | 27,754 | Form 4 |
| 24 | Twiford J Rainer Director | 2023-04-21 20:36:31 | 18,000 0 | 18,000 | Form 4 |
| 25 | LARUE WILLIAM R Director | 2023-04-21 20:37:53 | 18,000 0 | 18,000 | Form 4 |
| 26 | WORLAND STEPHEN T Director | 2023-04-21 20:41:50 | 18,000 0 | 18,000 | Form 4 |
| 27 | MATTINGLY MARTIN A Director | 2023-04-21 20:44:49 | 18,000 0 | 18,000 | Form 4 |
| 28 | PELLETIER SAUNDRA L Director | 2023-04-21 20:48:32 | 18,000 0 | 18,000 | Form 4 |
| 29 | Lam Carol C. Director | 2023-04-21 20:52:54 | 18,000 0 | 18,000 | Form 4 |
| 30 | Johnson-Pratt Lisa Director | 2023-04-21 20:55:25 | 18,000 0 | 18,000 | Form 4 |
| 31 | Walker Paul Edward Director | 2020-06-16 17:27:55 | 4,500 0 | 4,500 | Form 4 |
| 32 | SHAZER RONALD L Chief Medical Officer | 2016-06-07 19:59:21 | 335 0 | 335 | Form 4 |
| 33 | Hozoji Hironori Director | 2015-01-29 20:30:47 | 0 0 | 0 | Form 3 |
| 34 | Lazar David E. Chief Business Dev Officer | 2024-05-13 17:00:43 | 0 0 | 0 | Form 3 |
| 35 | Opaleye Management Inc. 10% Owner | 2024-02-09 16:05:32 | 0 0 | 0 | Form 13D |
| 36 | New Enterprise Associates 14 L.P. NEA Partners 14 L.P. NEA 14 GP LTD 10% Owner | 2021-03-10 21:40:44 | 0 0 | 0 | Form 13D |
| 37 | Harada Kenji Director | 2015-01-29 20:31:38 | 0 0 | 0 | Form 3 |