| 1 | Bain Capital Life Sciences Investors LLC Bain Capital Life Sciences Partners LP Bain Capital Life Sciences Fund L.P. BCIP Life Sciences Associates LP 10% Owner | 2026-05-22 16:30:06 | 0 12,823,560 | 12,823,560 | Form 4 |
| 2 | Schwartz Jeffrey Lawrence Director 10% Owner | 2024-05-28 16:59:40 | 42,950 8,434,560 | 8,477,510 | Form 4 |
| 3 | Bain Capital Life Sciences Investors LLC Bain Capital Life Sciences Partners LP Bain Capital Life Sciences Fund L.P. BCIP Life Sciences Associates LP Schwartz Jeffrey Lawrence Koppel Adam 10% Owner | 2022-02-14 06:37:59 | 7,651,369 0 | 7,651,369 | Form 13G |
| 4 | KENNEDY LEWIS MANAGEMENT LP Kennedy Lewis Capital Partners Master Fund II LP Kennedy Lewis GP II LLC Kennedy Lewis Investment Holdings II LLC Kennedy Lewis Capital Partners Master Fund III LP Kennedy Lewis GP III LLC KENNEDY LEWIS INVESTMENT MANAGEMENT LLC KLM GP LLC Richman Darren CHENE DAVID 10% Owner | 2022-08-29 10:35:01 | 5,179,061 0 | 5,179,061 | Form 13D |
| 5 | Longitude Capital Partners II LLC Longitude Venture Partners II L.P. Longitude Prime Partners LLC Longitude Prime Fund L.P. ENRIGHT PATRICK G Tammenoms Bakker Juliet 10% Owner | 2026-05-15 16:43:01 | 3,529,245 0 | 3,529,245 | Form 13G |
| 6 | Spignesi Robert G. Jr. PRESIDENT AND CEO | 2026-06-02 19:40:00 | 1,216,145 0 | 1,216,145 | Form 4 |
| 7 | WIRTJES SEAN M CHIEF FINANCIAL OFFICER | 2026-06-02 19:41:27 | 594,555 0 | 594,555 | Form 4 |
| 8 | Paris Jonathan SVP, GENERAL COUNSEL | 2023-03-13 21:25:57 | 325,398 0 | 325,398 | Form 4 |
| 9 | Wilson John J. Addington CHIEF OPERATING OFFICER | 2026-03-12 19:53:23 | 316,762 0 | 316,762 | Form 4 |
| 10 | Grewal Gurinder 10% Owner | 2021-07-20 20:16:25 | 294,990 0 | 294,990 | Form 4 |
| 11 | Kollender Richard S Director | 2026-05-26 19:25:06 | 169,018 0 | 169,018 | Form 4 |
| 12 | Noyes Michael Andrew 10% Owner | 2021-07-14 19:34:45 | 135,281 0 | 135,281 | Form 3 |
| 13 | KEYS RICHARD A CHIEF COMMERCIAL OFFICER | 2022-02-15 19:37:34 | 131,250 0 | 131,250 | Form 4 |
| 14 | PEI MELINDA LITHERLAND Director | 2026-06-02 19:44:06 | 126,261 0 | 126,261 | Form 4 |
| 15 | VEZINA VICTORIA CHIEF HUMAN RESOURCES OFFICER | 2024-03-12 21:21:56 | 112,608 0 | 112,608 | Form 4 |
| 16 | Malloy Kirk Director | 2026-06-02 19:42:37 | 86,261 10,000 | 96,261 | Form 4 |
| 17 | LOWENSTEIN INESE Director | 2026-06-02 19:45:47 | 96,261 0 | 96,261 | Form 4 |
| 18 | Bika Dafni Director | 2026-05-26 19:24:39 | 58,000 0 | 58,000 | Form 4 |
| 19 | Hirsch David Director | 2024-05-28 18:59:56 | 42,950 0 | 42,950 | Form 4 |
| 20 | RICCIARDI NATALE S Director | 2026-03-02 18:11:14 | 29,442 0 | 29,442 | Form 4 |
| 21 | Schmitz Alexander Director | 2021-07-15 20:02:23 | 25,000 0 | 25,000 | Form 4 |