| 1 | Pullara Samuel J III 10% Owner | 2014-10-03 19:01:59 | 0 4,715,398 | 4,715,398 | Form 4 |
| 2 | Dyckerhoff Stefan A 10% Owner | 2014-10-03 19:01:56 | 0 4,715,398 | 4,715,398 | Form 4 |
| 3 | Broxson Michael Director 10% Owner | 2017-08-10 17:30:02 | 0 2,922,993 | 2,922,993 | Form 3 |
| 4 | Morenstein Scott D CDK ASSOCIATES L.L.C. CAXTON CORP Kovner Bruce Director | 2019-11-25 16:24:33 | 0 2,052,991 | 2,052,991 | Form 4 |
| 5 | TIDMARSH GEORGE F Founder and President | 2005-03-15 18:47:29 | 992,219 18,216 | 1,010,435 | Form 4 |
| 6 | BIRD JEFFREY W Director | 2017-06-02 18:17:31 | 919 1,008,552 | 1,009,471 | Form 4 |
| 7 | COXE TENCH 10% Owner | 2014-10-03 19:01:54 | 0 614,956 | 614,956 | Form 4 |
| 8 | Kroll Stewart M. Chief Operating Officer | 2016-03-15 18:47:39 | 300,000 0 | 300,000 | Form 4 |
| 9 | OSTRACH MICHAEL S Chief Operating Officer | 2006-10-02 20:35:23 | 300,000 0 | 300,000 | Form 4/A |
| 10 | WHITE JAMES N 10% Owner | 2014-10-03 19:09:14 | 4,076 264,669 | 268,745 | Form 4 |
| 11 | Pearce Tillman Chief Medical Officer | 2016-03-15 18:49:10 | 200,000 0 | 200,000 | Form 4 |
| 12 | Waltzman Roger J. See remarks | 2023-02-17 08:00:14 | 170,000 0 | 170,000 | Form 4 |
| 13 | YOUNGER WILLIAM H JR 10% Owner | 2014-10-03 19:10:17 | 0 161,027 | 161,027 | Form 4 |
| 14 | Colowick Alan Chief Medical Officer | 2006-10-02 20:35:45 | 150,000 0 | 150,000 | Form 4/A |
| 15 | Curd John G President and CMO | 2011-03-15 18:59:10 | 132,602 0 | 132,602 | Form 4 |
| 16 | BAKER G LEONARD JR 10% Owner | 2014-10-03 19:01:51 | 0 132,161 | 132,161 | Form 4 |
| 17 | Cutler Adam D. See remarks | 2021-02-17 17:02:41 | 125,000 0 | 125,000 | Form 4 |
| 18 | Davis Cathleen Phillips VP, Finance and Controller | 2007-03-22 19:28:21 | 100,000 0 | 100,000 | Form 4 |
| 19 | Davar Nipun Vice President | 2015-03-02 19:44:28 | 100,000 0 | 100,000 | Form 4 |
| 20 | SIMON ROBERT L Senior Vice President | 2015-03-02 19:42:41 | 100,000 0 | 100,000 | Form 4 |
| 21 | SHEEHAN ANDREW T 10% Owner | 2014-10-03 19:03:03 | 0 78,165 | 78,165 | Form 4 |
| 22 | SWEARSON JANET I Chief Financial Officer | 2006-03-15 09:36:32 | 75,000 0 | 75,000 | Form 4 |
| 23 | Kaster Kevin R Sr. VP Corporate Development | 2007-03-22 19:28:10 | 75,000 0 | 75,000 | Form 4 |
| 24 | GAITHER JAMES C 10% Owner | 2014-10-03 19:01:57 | 0 69,412 | 69,412 | Form 4 |
| 25 | Valacer David Chief Medical Officer | 2017-08-11 17:24:25 | 57,321 0 | 57,321 | Form 3 |
| 26 | Brawer Michael Interim Chief Medical Officer | 2007-03-22 19:27:59 | 50,000 0 | 50,000 | Form 4 |
| 27 | COZADD BRUCE C Director | 2016-06-28 15:24:30 | 35,000 0 | 35,000 | Form 4 |
| 28 | Parkinson David Ross Director | 2016-06-28 15:28:52 | 35,000 0 | 35,000 | Form 4 |
| 29 | JAEGER WILFRED E Director | 2016-06-28 15:38:04 | 35,000 0 | 35,000 | Form 4 |
| 30 | PARKER GEORGE GC Director | 2016-06-28 15:43:47 | 35,000 0 | 35,000 | Form 4 |
| 31 | McLennan Sean See remarks | 2022-06-21 07:30:09 | 30,000 0 | 30,000 | Form 4 |
| 32 | Fernandes Joel A Senior Vice President | 2016-04-29 16:03:54 | 28,120 0 | 28,120 | Form 4 |
| 33 | Poma Eric E See remarks | 2024-01-25 17:32:39 | 23,333 0 | 23,333 | Form 4 |
| 34 | ANDERSON DAVID L 10% Owner | 2014-10-03 19:00:48 | 0 15,891 | 15,891 | Form 4 |
| 35 | Hirsch David Director | 2022-06-06 07:30:17 | 15,000 0 | 15,000 | Form 4 |
| 36 | Morenstein Scott D Director | 2021-06-04 16:30:37 | 15,000 0 | 15,000 | Form 4 |
| 37 | POWELL MICHAEL Director | 2008-05-14 17:15:25 | 15,000 0 | 15,000 | Form 4 |
| 38 | Speiser Michael L 10% Owner | 2014-10-03 19:03:05 | 0 11,884 | 11,884 | Form 4 |
| 39 | SWEET DAVID E 10% Owner | 2014-10-03 19:09:13 | 0 11,312 | 11,312 | Form 4 |
| 40 | HALTER WILLIAM A Director | 2009-05-26 18:13:40 | 10,000 0 | 10,000 | Form 4 |
| 41 | Kim Jason S. Chief Financial Officer | 2024-01-25 17:34:18 | 10,000 0 | 10,000 | Form 4 |
| 42 | Voi Maurizio Chief Medical Officer | 2024-01-25 17:49:08 | 10,000 0 | 10,000 | Form 4 |
| 43 | Lanfear Jonathan Director | 2023-10-31 18:46:09 | 1000 0 | 1000 | Form 4 |
| 44 | Sanders Corazon (Corsee) D. Director | 2024-09-30 17:35:45 | 1000 0 | 1000 | Form 4 |
| 45 | HOFFMANN DAVE Director | 2024-09-30 17:36:32 | 1000 0 | 1000 | Form 4 |
| 46 | SELICK HAROLD E Director | 2024-09-30 17:36:35 | 1000 0 | 1000 | Form 4 |
| 47 | Gruia Gabriela Director | 2024-09-30 17:37:40 | 1000 0 | 1000 | Form 4 |
| 48 | LALANDE KEVIN M. Director 10% Owner | 2024-09-30 17:41:36 | 1000 0 | 1000 | Form 4 |
| 49 | BIOTECH TARGET N V BB BIOTECH AG 10% Owner | 2024-11-18 21:49:56 | 0 0 | 0 | Form 13G |
| 50 | SHV Management Services LLC Cunningham Joe H FRENCH DOUGLAS D SHV Management Services LP SHV Annex Services LP Sante Health Ventures I Annex Fund LP SANTE HEALTH VENTURES I LP 10% Owner | 2024-04-02 21:56:01 | 0 0 | 0 | Form 13D |
| 51 | Frazier Healthcare VI L.P. FHM VI L.P. FHM VI L.L.C. 10% Owner | 2012-02-23 16:34:33 | 0 0 | 0 | Form 13G |
| 52 | Longitude Capital Partners III LLC Longitude Venture Partners III L.P. ENRIGHT PATRICK G Tammenoms Bakker Juliet 10% Owner | 2024-04-29 21:51:58 | 0 0 | 0 | Form 13D |
| 53 | PROQUEST INVESTMENTS II LP PROQUEST INVESTMENTS II ADVISORS FUND LP PROQUEST ASSOCIATES II LLC Moorin Jay SCHREIBER ALAIN 10% Owner | 2007-02-12 14:00:26 | 0 0 | 0 | Form 13G |
| 54 | MILLENNIUM PHARMACEUTICALS INC Takeda Pharmaceuticals International AG Takeda Pharma A/S Takeda A/S Takeda Europe Holdings B.V. TAKEDA PHARMACEUTICAL CO LTD Takeda Pharmaceuticals U.S.A. Inc. 10% Owner | 2021-09-14 06:13:13 | 0 0 | 0 | Form 13D |
| 55 | MORGENTHALER PARTNERS VII LP Christoffersen Ralph E 10% Owner | 2007-02-12 12:41:24 | 0 0 | 0 | Form 13G |
| 56 | THREE ARCH MANAGEMENT III LLC THREE ARCH PARTNERS III LP WAN MARK A JAEGER WILFRED E NICHOLSON BARCLAY THREE ARCH ASSOCIATES III LP 10% Owner | 2013-02-13 19:10:07 | 0 0 | 0 | Form 13G |
| 57 | ALTA BIOPHARMA PARTNERS III LP ALTA BIOPHARMA PARTNERS III GMBH & CO BETEILIGUNGS KG ALTA EMBARCADERO BIOPHARMA PARTNERS III LLC DELEAGE JEAN CHAMPSI FARAH PENHOET EDWARD HURWITZ EDWARD ALTA BIOPHARMA MANAGEMENT III LLC MARDUEL ALIX 10% Owner | 2013-02-12 19:53:27 | 0 0 | 0 | Form 13G |
| 58 | TANG KEVIN C TANG CAPITAL MANAGEMENT LLC TANG CAPITAL PARTNERS LP 10% Owner | 2010-02-16 17:08:15 | 0 0 | 0 | Form 13G |
| 59 | ALTA BIOPHARMA PARTNERS III LP ALTA BIOPHARMA PARTNERS III GMBH & CO BETEILIGUNGS KG ALTA BIOPHARMA MANAGEMENT III LLC ALTA EMBARCADERO BIOPHARMA PARTNERS III LLC DELEAGE JEAN CHAMPSI FARAH PENHOET EDWARD HURWITZ EDWARD Former 10% owner | 2013-02-12 19:53:27 | 0 0 | 0 | Form 13G |
| 60 | POWELL MICHAEL SOFINNOVA VENTURE AFFILIATES V LP SOFINNOVA VENTURE PARTNERS V LP SOFINNOVA VENTURE PRINCIPALS V LP Azan Alain HEALY JAMES Sofinnova Management V LLC Director 10% Owner | 2006-02-14 13:03:17 | 0 0 | 0 | Form 13G |
| 61 | HealthCare Ventures VIII L.P. HealthCare Partners VIII L.P. HealthCare Partners VIII LLC CAVANAUGH JAMES H LAWLOR AUGUSTINE LITTLECHILD JOHN W Mirabelli Christopher WERNER HAROLD R 10% Owner | 2012-03-01 15:50:35 | 0 0 | 0 | Form 13G |
| 62 | PEQUOT CAPITAL MANAGEMENT INC ENRIGHT PATRICK G See Footnote 1 | 2007-03-02 16:40:04 | 0 0 | 0 | Form 4 |
| 63 | SUTTER HILL VENTURES BAKER G LEONARD JR ANDERSON DAVID L YOUNGER WILLIAM H JR COXE TENCH SANDS GREGORY P GAITHER JAMES C WHITE JAMES N SWEET DAVID E SHEEHAN ANDREW T 10% Owner | 2018-02-14 10:44:16 | 0 0 | 0 | Form 13G |
| 64 | SUTTER HILL VENTURES 10% Owner | 2018-02-14 10:44:16 | 0 0 | 0 | Form 13G |
| 65 | SUTTER HILL ENTREPRENEURS FUND QP LP BIRD JEFFREY W 10% Owner | 2014-06-23 18:10:25 | 0 0 | 0 | Form 4 |
| 66 | SUTTER HILL ENTREPRENEURS FUND AI LP BIRD JEFFREY W 10% Owner | 2014-06-23 18:10:23 | 0 0 | 0 | Form 4 |