Sec Form 4 Filing - ENGBERS WILLIAM @ LA JOLLA PHARMACEUTICAL CO - 2005-05-19

FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person ENGBERS WILLIAM 2. Issuer Name and Ticker or Trading Symbol LA JOLLA PHARMACEUTICAL CO [ LJPC] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) X __ Director _____ 10% Owner _____ Officer (give title below) _____ Other (specify below) (Last) (First) (Middle) 6455 NANCY RIDGE DRIVE 3. Date of Earliest Transaction (MM/DD/YY) 05/19/2005 (Street) SAN DIEGO, CA92121 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) __ X __ Form filed by One Reporting Person _____ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares Stock Options (right to buy) $ 3.625 05/19/2005 D 20,000 ( 1 ) 05/19/2007 Common Stock 20,000 $ 0 128,795 D Stock Options (right to buy) $ 3.625 05/19/2005 A 20,000 ( 1 ) 12/03/2008 Common Stock 20,000 $ 0 148,795 D Stock Options (right to buy) $ 0.484 05/19/2005 D 41,143 ( 2 ) 05/19/2007 Common Stock 41,143 $ 0 107,652 D Stock Options (right to buy) $ 0.484 05/19/2005 A 41,143 ( 2 ) 09/28/2009 Common Stock 41,143 $ 0 148,795 D Stock Options (right to buy) $ 0.344 05/19/2005 D 4,011 ( 3 ) 05/19/2007 Common Stock 4,011 $ 0 144,784 D Stock Options (right to buy) $ 0.344 05/19/2005 A 4,011 ( 3 ) 11/02/2009 Common Stock 4,011 $ 0 148,795 D Stock Options (right to buy) $ 3.688 05/19/2005 D 10,846 ( 4 ) 05/19/2007 Common Stock 10,846 $ 0 137,949 D Stock Options (right to buy) $ 3.688 05/19/2005 A 10,846 ( 4 ) 01/28/2010 Common Stock 10,846 $ 0 148,795 D Stock Options (right to buy) $ 2.97 05/19/2005 D 5,000 ( 5 ) 05/19/2007 Common Stock 5,000 $ 0 143,795 D Stock Options (right to buy) $ 2.97 05/19/2005 A 5,000 ( 5 ) 05/12/2013 Common Stock 5,000 $ 0 148,795 D Stock Options (right to buy) $ 4.71 05/19/2005 D 5,000 ( 6 ) 05/19/2007 Common Stock 5,000 $ 0 143,795 D Stock Options (right to buy) $ 4.71 05/19/2005 A 5,000 ( 6 ) 09/18/2013 Common Stock 5,000 $ 0 148,795 D

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other ENGBERS WILLIAM 6455 NANCY RIDGE DRIVE SAN DIEGO, CA92121 X Signatures /s/ Gail A. SloanAttorney-in-fact for William E. Engbers 05/20/2005 Signature of Reporting Person Date

Explanation of Responses:

( 1 )Amendment of outstanding option resulting in deemed cancellation of option and grant of replacement option. The option was originally granted on 12/03/1998. Options were fully vested on 12/03/2000. ( 2 )Amendment of outstanding option resulting in deemed cancellation of option and grant of replacement option. The option was originally granted on 09/28/1999. Options were fully vested on 12/28/2000. ( 3 )Amendment of outstanding option resulting in deemed cancellation of option and grant of replacement option. The option was originally granted on 11/02/1999. Options were fully vested on 12/02/2000. ( 4 )Amendment of outstanding option resulting in deemed cancellation of option and grant of replacement option. The option was originally granted on 01/28/2000. Options were fully vested on 12/28/2000. ( 5 )Amendment of outstanding option resulting in deemed cancellation of option and grant of replacement option. The option was originally granted on 05/12/2003. On 5/19/2005, 3,333 options were vested. Mr. Engbers ceased being a director of the Company on 05/19/2005. Immediately prior to his cessation of service as a director the vesting period was accelerated so that all options were fully vested on 5/19/2005. ( 6 )Amendment of outstanding option resulting in deemed cancellation of option and grant of replacement option. The option was originally granted on 09/18/2003. On 5/19/2005, 2,778 options were vested. Mr. Engbers ceased being a director of the Company on 05/19/2005. Immediately prior to his cessation of service as a director the vesting period was accelerated so that all options were fully vested on 5/19/2005.

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

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