Sec Form 3 Filing - Boyer David W. @ NEUROCRINE BIOSCIENCES INC - 2022-02-04

FORM 3 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person Boyer David W. 2. Issuer Name and Ticker or Trading Symbol NEUROCRINE BIOSCIENCES INC [ NBIX] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director _____ 10% Owner X __ Officer (give title below) _____ Other (specify below) Chief Corp. Affairs Officer (Last) (First) (Middle) 12780 EL CAMINO REAL 3. Date of Earliest Transaction (MM/DD/YY) 02/04/2022 (Street) SAN DIEGO, CA 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) __ X __ Form filed by One Reporting Person _____ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 2,075 D

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares Incentive Stock Option $ 89.23 ( 1 ) 10/01/2029 Common Stock 4,480 D Non-Qu alified Stock Option $ 89.23 ( 1 ) 10/01/2029 Common Stock 43,724 D Incentive Stock Option $ 102.9 ( 2 ) 02/06/2030 Common Stock 479 D Non-Qualified Stock Option $ 102.9 ( 2 ) 02/06/2030 Common Stock 11,024 D Incentive Stock Option $ 117.63 ( 3 ) 02/08/2031 Common Stock 1,281 D Non-Qualified Stock Option $ 117.63 ( 3 ) 02/08/2031 Common Stock 33,754 D Incentive Stock Option $ 79.02 ( 4 ) 01/31/2032 Common Stock 1,190 D Non-Qualified Stock Option $ 79.02 ( 4 ) 01/31/2032 Common Stock 55,907 D Restricted Stock Unit ( 6 ) ( 5 ) ( 5 ) Common Stock 10,927 D Restricted Stock Unit ( 6 ) ( 7 ) ( 7 ) Common Stock 1,823 D Restricted Stock Unit ( 6 ) ( 8 ) ( 8 ) Common Stock 5,314 D Restriced Stock Unit ( 6 ) ( 9 ) ( 9 ) Common Stock 8,384 D

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other Boyer David W. 12780 EL CAMINO REAL SAN DIEGO, CA Chief Corp. Affairs Officer Signatures /s/ David Boyer 02/09/2022 Signature of Reporting Person Date

Explanation of Responses:

( 1 )Option granted October 1, 2019 and vests at 25% upon first anniversary (October 1, 2020) and remaining 75% vesting in 36 equal monthly installments beginning November 1, 2020. ( 2 )Option granted Fe bruary 6, 2020 and vests monthly over four years. ( 3 )Option granted February 8, 2021 and vests monthly over four years. ( 4 )Option granted January 31, 2022 and vests monthly over four years. ( 5 )1/4 of the Restricted Stock Units vested on October 1, 2020 and October 1, 2021. The remaining units vest equally on each of October 1, 2022, October 1, 2023. ( 6 )Each Restricted Stock Unit represents a contingent right to receive one share of the Issuer Common Stock. ( 7 )1/4th of the Restricted Stock Units vested on February 6, 2021. The remaining units vest equally on each of February 6, 2022, February 6, 2023, February 6, 2024. ( 8 )The Restricted Stock Units will vest annually at 1/4 of the units vesting on each of February 8, 2022, February 8, 2023, February 8, 2024, and February 8, 2025. ( 9 )The Restricted Stock Units will vest annually at 1/4 of the units vesting on each of January 31, 2023, January 31, 2024, January 31, 2025, January 26, 2026.

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).

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