Sec Form 3 Filing - Sharma Mani @ ASTRAZENECA PLC - 2026-03-18

FORM 3 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL OMB Number: 3235-0287 Expires: November 30, 2011 Estimated average burden hours per response... 0.5

1. Name and Address of Reporting Person Sharma Mani 2. Issuer Name and Ticker or Trading Symbol ASTRAZENECA PLC [ AZN] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director _____ 10% Owner X __ Officer (give title below) _____ Other (specify below) See Remarks (Last) (First) (Middle) C/O ASTRAZENECA PLC 1 FRANCIS, CRICK AVENUE CAMBRIDGE BIOMEDICAL CAMPUS 3. Date of Earliest Transaction (MM/DD/YY) 03/18/2026 (Street) CAMBRIDGECB2 0AA 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) __ X __ Form filed by One Reporting Person _____ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Ordinary Shares 31,153.4659 D

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares Restricted Stock Units ( 1 ) ( 1 ) ( 1 ) Ordinary Shares 2,996.308 D Dividend Equivalent Rights ( 2 ) ( 2 ) ( 2 ) Ordinary Shares 31.297 D Employee Stock Option (right to buy) $ 123.98 ( 3 ) 12/01/2028 06/01/2029 Ordinary Shares 195 D

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other Sharma Mani C/O ASTRAZENECA PLC 1 FRANCIS CRICK AVENUE CAMBRIDGE BIOMEDICAL CAMPUS CAMBRIDGECB2 0AA See Remarks Signatures /s/ Mani Sharma 03/19/2026 Signature of Reporting Person Date

Explanation of Responses:

( 1 )Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer. The RSUs vest on November 16, 2028. Vested ordinary shares will be delivered to the reporting person on November 17, 2028. ( 2 )Dividend equivalent rights accrue on the reporting person's RSUs when and as dividends are paid on the Issuer's ordinary shares and vest along with the RSUs on which they accrued. Each dividend equivalent right converts into one ordinary share of the Issuer on the date of vesting. ( 3 )The exercise price for these options under the Issuer's Savings Related Share Option Scheme is denominated in British pounds sterling at a price of GBP93.64 per ordinary share. The exercise price reported herein was converted from British pounds sterling to United States dollars at a conversion rate of GBP1.0000 to $1.3240 on March 13, 2026 as published by the Board of Governors of the Federal Reserve System. The exercise price is the actual British pounds sterling amount regardless of the exchange rate on the date of exercise.

Remarks: SVP, Group Controller and Head of Global Finance Services

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).

** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.