Sec Form 4 Filing - Kummeth Charles R. @ BIO-TECHNE Corp - 2022-08-15

FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person Kummeth Charles R. 2. Issuer Name and Ticker or Trading Symbol BIO-TECHNE Corp [ TECH] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) X __ Director _____ 10% Owner X __ Officer (give title below) _____ Other (specify below) Chief Executive Officer (Last) (First) (Middle) 614 MCKINLEY PLACE NE 3. Date of Earliest Transaction (MM/DD/YY) 08/15/2022 (Street) MINNEAPOLIS, MN55413 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) __ X __ Form filed by One Reporting Person _____ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 240,403( 1 ) D Common Stock 100 I By Step-Son Common Stock 100 I By Step-Daughter

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares Stock Options (Right to Buy) $ 106.59 ( 2 ) 08/18/2023 Common Stock 256,010 256,010 D Stock Options (Right to Buy) $ 125.05 ( 2 ) 08/09/2024 Common Stock 194,771 194,771 D Stock Options (Right to Buy) $ 177.32 ( 2 ) 08/08/2025 Common Stock 90,334 90,334 D Stock Options (Right to Buy) $ 177.32 ( 2 ) 08/08/2025 Common Stock 60,222 60,222 D Stock Options (Right to Buy) $ 190.41 ( 2 ) 08/07/2026 Common Stock 85,725 85,725 D Restricted Stock Units ( 3 ) 08/15/2022 A 13,225 ( 4 ) ( 4 ) Common Stock 13,225 $ 0 13,225 D Stock Options (Right to Buy) $ 378.08 08/15/2022 A 300,000 ( 5 ) 08/15/2029 Common Stock 300,000 $ 0 300,000 D Stock Options (Right to Buy) $ 190.41 ( 6 ) 08/07/2026 Common Stock 57,150 57,150 D Restricted Stock Units ( 3 ) ( 7 ) ( 7 ) Common Stock 12,879 12,879 D Stock Options (Right to Buy) $ 267.87 ( 7 ) 08/05/2027 Common Stock 57,442 57,442 D Stock Options (Right to Buy) $ 267.87 ( 8 ) 08/05/2027 Common Stock 38,295 38,295 D Stock Options (Right to Buy) $ 267.87 ( 9 ) 08/05/2027 Common Stock 16,650 16,650 D Stock Options (Right to Buy) $ 267.87 ( 10 ) 08/05/2027 Common Stock 16,650 16,650 D Restricted Stock Units ( 3 ) ( 11 ) ( 11 ) Common Stock 8,016 8,016 D Stock Options (Right to Buy) $ 481.82 ( 11 ) 08/06/2028 Common Stock 31,315 31,315 D Stock Options (Right to Buy) $ 481.82 ( 12 ) 08/06/2028 Common Stock 20,876 20,876 D

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other Kummeth Charles R. 614 MCKINLEY PLACE NE MINNEAPOLIS, MN55413 X Chief Executive Officer Signatures /s/ Brenda S. Furlow, Attorney-in-Fact 08/17/2022 Signature of Reporting Person Date

Explanation of Responses:

( 1 )Includes (i) 2,862 shares of restricted stock for which the risk of forfeiture will lapse on August 5, 2023; and (ii) 3,562 shares of restricted stock for which the risk of forfeiture will lapse as to 1,782 shares on each of August 6, 2023 and August 6, 2024. ( 2 )Fully exercisable. ( 3 )Each restricted stock unit represents a contingent right to receive one share of Bio-Techne common stock. ( 4 )4,408 shares vest on each of 8/15/2023 and 8/15/2025, and 4,409 shares vest on 8/15/2024. ( 5 )150,000 options vest in full or in part on 7/1/2023 if certain performance goals are achieved (or such later date as performance is certified by the Administrator), and 150,000 options vest in full or in part on 7/1/2024 if certain performance goals are achieved (or such later date as performance is certified by the Administrator). ( 6 )Options to purchase 14,288 shares vest on each of 8/7/2020 and 8/7/2021 and options to purchase 14,287 shares vest on each of 8/7/2022 and 8/7/2023. ( 7 )Vests in full or in part on 8/5/2023 if certain performance goals are achieved (or such later date as performance is certified by the Administrator). ( 8 )Options to purchase 9,573 shares vest on 8/5/21 and options to purchase 9,574 shares vest on each of 8/5/22, 8/5/23 and 8/5/24. ( 9 )Vests in full on the date performance of certain product revenue goals during the period of fiscal 2021-2023 is certified by the Administrator, in no event earlier than 8/5/2021. ( 10 )Options to purchase 5,550 shares vest on each of 8/5/21, 8/5/22 and 8/5/23. ( 11 )Vests in full or in part on 8/6/2024 if certain performance goals are achieved (or such later date as performance is certified by the Administrator). ( 12 )Options to purchase 5,219 shares vest on each of 8/6/2022, 8/6/2023, 8/6/2024 and 8/6/2025.

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).

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