Sec Form 4 Filing - FOTIADES GEORGE L @ CARDINAL HEALTH INC - 2005-12-29

FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person FOTIADES GEORGE L 2. Issuer Name and Ticker or Trading Symbol CARDINAL HEALTH INC [ CAH] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director _____ 10% Owner X __ Officer (give title below) _____ Other (specify below) President & COO (Last) (First) (Middle) 7000 CARDINAL PLACE 3. Date of Earliest Transaction (MM/DD/YY) 12/29/2005 (Street) DUBLIN, OH43017 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) __ X __ Form filed by One Reporting Person _____ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Shares 12/29/2005 F( 1 ) 623 D $ 66.3 ( 2 ) 80,239 ( 3 ) D

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares Option (right to buy) ( 4 ) $ 41.553 09/16/2001 09/16/2008 Common Shares 56,250 1 D Option (right to buy) ( 4 ) $ 47.333 03/01/2002 03/01/2009 Common Shares 27,171 1 D Option (right to buy) ( 4 ) $ 31.167 11/15/2002 11/15/2009 Common Shares 67,907 1 D Option (right to buy) ( 4 ) $ 66.083 11/20/2003 11/20/2010 Common Shares 60,530 1 D Option (right to buy) ( 4 ) $ 68.1 11/19/2004 11/19/2011 Common Shares 67,915 1 D Option (right to buy) ( 4 ) $ 67.9 11/18/2005 11/18/2012 Common Shares 250,000 1 D Option (right to buy) ( 4 ) $ 64.11 01/31/2007 02/01/2014 Common Shares 225,000 1 D

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other FOTIADES GEORGE L 7000 CARDINAL PLACE DUBLIN, OH43017 President & COO Signatures George L. Fotiades 01/03/2006 Signature of Reporting Person Date

Explanation of Responses:

( 1 )Represents a reduction in shares underlying restricted share units to satisfy the tax withholding obligations of the Company with respect to the prior vesting of 26,362 restricted share units. ( 2 )Weighted average price of two transactions: 383 shares at $64.59 and 240 shares at $69.02. ( 3 )Includes the addition of 12 shares due to a typographical error in a prior filing reporting a transaction on 12/13/00. ( 4 )Stock option granted pursuant to the Cardinal health, Inc. Equity Incentive Plan.

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).

** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

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