Sec Form 4 Filing - Wolf James G. @ ENZO BIOCHEM INC - 2023-01-23

FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person Wolf James G. 2. Issuer Name and Ticker or Trading Symbol ENZO BIOCHEM INC [ ENZ] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director X __ 10% Owner _____ Officer (give title below) _____ Other (specify below) (Last) (First) (Middle) 105, FLYWAY DRIVE 3. Date of Earliest Transaction (MM/DD/YY) 01/23/2023 (Street) KIAWAH ISLAND, SC29455 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) __ X __ Form filed by One Reporting Person _____ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock, $0.01 par value 01/23/2023 C( 1 ) 228,700 A $ 2.5 4,043,700 D Common Stock, $0.01 par value 01/23/2023 C( 2 ) 34,500 A $ 5 4,078,200 D Common Stock, $0.01 par value 418,500 I See Footnote( 3 )

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares Short Put Option (obligation to buy) $ 2.5 01/23/2023 C( 1 ) 2,287 11/01/2022 01/20/2023 Common Stock, $0.01 par value 228,700 $ 0 0 D Short Put Option (obligation to buy) $ 5 01/23/2023 C( 2 ) 345 10/28/2022 01/20/2023 Common Stock, $0.01 par value 34,500 $ 0 0 D

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other Wolf James G. 105, FLYWAY DRIVE KIAWAH ISLAND, SC29455 X Signatures James G. Wolf 01/23/2023 Signature of Reporting Person Date

Explanation of Responses:

( 1 )The counterparty to certain of the Reporting Person's outstanding short put options exercised such options and the Reporting Person was obligated to purchase these shares at an exercise price of $2.50 per share. ( 2 )The counterparty to certain of the Reporting Person's outstanding short put options exercised such options and the Reporting Person was obligated to purchase these shares at an exercise price of $5.00 per share. ( 3 )These 418,500 shares owned indirectly by the Reporting Person include 116,000 shares held in qualified retirement accounts in the name, and for the benefit, of the Reporting Person, 22,000 shares held in qualified retirement accounts in the name, and for the benefit, of the Reporting Person's spouse, 110,000 shares owned directly by the Reporting Person's sibling and 170,500 shares owned directly by adult children of the Reporting Person. The Reporting Person disclaims beneficial ownership of such shares except to the extent of his pecuniary interest, if any.

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).

** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

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