Sec Form 3/A Filing - Wolf James G. @ ENZO BIOCHEM INC - 2022-10-28

FORM 3/A Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person Wolf James G. 2. Issuer Name and Ticker or Trading Symbol ENZO BIOCHEM INC [ ENZ] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director X __ 10% Owner _____ Officer (give title below) _____ Other (specify below) (Last) (First) (Middle) 105, FLYWAY DRIVE 3. Date of Earliest Transaction (MM/DD/YY) 10/28/2022 (Street) KIAWAH ISLAND, SC29455 4. If Amendment, Date Original Filed (MM/DD/YY) 01/09/2023 6. Individual or Joint/Group Filing (Check Applicable Line) __ X __ Form filed by One Reporting Person _____ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock, $0.01 par value 3,560,000 D Common Stock, $0.01 par value 116,000 I See Footnote( 1 ) Common Stock, $0.01 par value 22,000 I See Footnote( 2 ) Common Stock, $0.01 par value 110,000 I See Footnote( 3 ) Common Stock, $0.01 par value 170,500 I See Footnote( 4 )

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares Long Call Option (right to buy) $ 2.5 10/28/2022( 5 ) 01/20/2023 Common Stock 275,000 D Long Call Option (right to buy) $ 5 10/28/2022( 5 ) 01/20/2023 Common Stock 200,000 D Long Call Option (right to buy) $ 2.5 10/28/2022( 5 ) 04/21/2023 Common Stock 75,000 D Long Call Option (right to buy) $ 5 10/28/2022( 5 ) 04/21/2023 Common Stock 80,700 D Long Call Option (right to buy) $ 7.5 10/28/2022( 5 ) 04/21/2023 Common Stock 75,000 D Short Put Option (obligation to buy) $ 2.5 10/28/2022( 6 ) 01/20/2023 Common Stock 400,000 D Short Put Option (obligation to buy) $ 5 10/28/2022( 6 ) 01/20/2023 Common Stock 34,500 D Short Put Option (obligation to buy) $ 2.5 10/28/2022( 6 ) 04/21/2023 Common Stock 30,000 D Short Put Option (obligation to buy)( 7 ) $ 2.5 10/28/2022( 6 ) 11/18/2022 Common Stock 23,900 D

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other Wolf James G. 105, FLYWAY DRIVE KIAWAH ISLAND, SC29455 X Signatures James G. Wolf 01/12/2023 Signature of Reporting Person Date

Explanation of Responses:

( 1 )These shares are held in qualified retirement accounts in the name, and for the benefit, of the Reporting Person. ( 2 )These shares are held in a qualified retirement account in the name, and for the benefit, of the Reporting Person's spouse. The Reporting Person has dispositive and voting control over the retirement account. The Reporting Person disclaims beneficial ownership of the securities held by this retirement account, except to the extent of his pecuniary interest therein, if any, and this report shall not be deemed an admission that he is the beneficial owner of such securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose. ( 3 )These shares are held directly by the Reporting Person's sibling. The Reporting Person maintains a power of attorney granted by the Reporting Person's sibling with respect to these shares, including voting and dispositive power over the shares. The Reporting Person has no pecuniary interest in the shares and disclaims beneficial ownership of the securities held by his sibling. This report shall not be deemed an admission that the Reporting Person is the beneficial owner of such securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose. ( 4 )These shares are held directly by the Reporting Person's adult children, each holding a portion of the shares individually. The Reporting Person maintains powers of attorney granted by each of his adult children with respect to these shares, including voting and dispositive power over the shares. The Reporting Person has no pecuniary interest in the shares and disclaims beneficial ownership of the securities held by his adult children. This report shall not be deemed an admission that the Reporting Person is the beneficial owner of such securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose. ( 5 )Each call option may be exercised from the date it was purchased through the expiration date of the call option. ( 6 )Each put option may be exercised by the owner of the option at any time from the date of its sale through the expiration date of the put option. ( 7 )This amendment to Form 3 is being filed to correct the original Form 3 filed on January 9, 2023. The original Form 3 inadvertently omitted certain short put options with an exercise price of $2.50 that expired on November 18, 2022.

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).

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