Sec Form 3 Filing - Scott Randal W. @ Freenome, Inc. - 2026-07-20

FORM 3 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person Scott Randal W. 2. Issuer Name and Ticker or Trading Symbol Freenome, Inc. [ FRNM] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) X __ Director _____ 10% Owner _____ Officer (give title below) _____ Other (specify below) (Last) (First) (Middle) C/O FREENOME, INC., 51 ASTOR PLACE, 10TH FLOOR 3. Date of Earliest Transaction (MM/DD/YY) 07/20/2026 (Street) NEW YORK, NY10003 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) __ X __ Form filed by One Reporting Person _____ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 12,235 D Common Stock 91,969 I By Thinking Bench Capital, LLC ( 1 )

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares Stock Option (right to buy) $ 2.83 ( 2 ) 07/25/2028 Common Stock 71,476 D Stock Option (right to buy) $ 15.91 ( 5 ) ( 2 ) 04/26/2032 Common Stock 6,061 D Stock Option (right to buy) $ 15.91 ( 5 ) ( 2 ) 06/27/2032 Common Stock 3,359 D Stock Option (right to buy) $ 14.92 ( 5 ) ( 3 ) 09/10/2033 Common Stock 3,359 D Stock Option (right to buy) $ 18.24 ( 5 ) ( 4 ) 03/01/2034 Common Stock 7,359 D Stock Option (right to buy) $ 14 ( 5 ) ( 2 ) 05/28/2035 Common Stock 9,588 D Stock Option (right to buy) $ 8.45 ( 2 ) 10/23/2035 Common Stock 6,484 D

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other Scott Randal W. C/O FREENOME, INC. 51 ASTOR PLACE, 10TH FLOOR NEW YORK, NY10003 X Signatures /s/ Thomas Fitzpatrick, Attorney-in-Fact 07/27/2026 Signature of Reporting Person Date

Explanation of Responses:

( 1 )Represents shares held by Thinking Bench Capital, LLC. The Reporting Person disclaims beneficial ownership of such shares for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), except to the extent of his pecuniary interest therein, if any. This report shall not be deemed an admission that he is a beneficial owner of such shares for the purpose of Section 16 of the Exchange Act, or for any other purpose. ( 2 )The shares subject to this option are fully vested. ( 3 )The shares subject to this option shall vest and become exercisable in forty-eight (48) equal monthly installments commencing from February 28, 2023, subject to the Reporting Person's continued service on each such vesting date. ( 4 )The shares subject to this option shall vest and become exercisable in forty-eight (48) equal monthly installments commencing from March 2, 2024, subject to the Reporting Person's continued service on each such vesting date. ( 5 )This option was previously amended, pursuant to which the exercise price of the option will be automatically reduced to $8.45 upon the occurrence of certain events.

Remarks: Exhibit 24 - Power of Attorney

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).

** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

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