Sec Form 4/A Filing - Loew Caroline @ Mural Oncology plc - 2023-12-14

FORM 4/A Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person Loew Caroline 2. Issuer Name and Ticker or Trading Symbol Mural Oncology plc [ MURA] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) X __ Director _____ 10% Owner X __ Officer (give title below) _____ Other (specify below) Chief Executive Officer (Last) (First) (Middle) C/O MURAL ONCOLOGY PLC, 10 EARLSFORT TERRACE 3. Date of Earliest Transaction (MM/DD/YY) 12/14/2023 (Street) DUBLIN 2, L2D02 T380 4. If Amendment, Date Original Filed (MM/DD/YY) 12/18/2023 6. Individual or Joint/Group Filing (Check Applicable Line) __ X __ Form filed by One Reporting Person _____ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares Stock Option (right to buy) $ 5.4809 ( 1 ) 12/14/2023( 2 ) A 379,690 ( 2 ) ( 3 ) 07/02/2033 Ordinary Shares 379,690 ( 2 ) 379,690 D

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other Loew Caroline C/O MURAL ONCOLOGY PLC 10 EARLSFORT TERRACE DUBLIN 2, L2D02 T380 X Chief Executive Officer Signatures /s/ Maiken Keson-Brookes, attorney-in-fact for Caroline Loew 04/11/2024 Signature of Reporting Person Date

Explanation of Responses:

( 1 )This amendment to Form 4 is being filed solely to correct the exercise price of the granted option, which was previously reported as being $3.61 due to a scrivener's error. ( 2 )Represents an option award originally granted by Alkermes plc ("Alkermes") that was converted into an option award of Mural Oncology plc (the "Issuer") in connection with the spin-off of the Issuer from Alkermes. ( 3 )This option was granted on December 14, 2023. The option is scheduled to vest with respect to 25% of the underlying ordinary shares on each of the first four anniversaries of July 5, 2023, subject to the reporting person's continued service with the Issuer.

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).

** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

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