Sec Form 3 Filing - Hollywood Mark @ Zymeworks Inc. - 2026-01-09

FORM 3 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL OMB Number: 3235-0287 Expires: November 30, 2011 Estimated average burden hours per response... 0.5

1. Name and Address of Reporting Person Hollywood Mark 2. Issuer Name and Ticker or Trading Symbol Zymeworks Inc. [ ZYME] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director _____ 10% Owner X __ Officer (give title below) _____ Other (specify below) EVP & Chief Operating Officer (Last) (First) (Middle) C/O ZYMEWORKS INC., 108 PATRIOT DRIVE, SUITE A 3. Date of Earliest Transaction (MM/DD/YY) 01/09/2026 (Street) MIDDLETOWN, DE19709 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) __ X __ Form filed by One Reporting Person _____ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 121,367 D

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares Stock Option (Right to Buy) $ 15.23 ( 1 )( 2 ) 03/26/2029 Common Stock 80,000 D Stock Option (Right to Buy) $ 35.2 ( 2 )( 3 ) 03/09/2030 Common Stock 24,375 D Stock Option (Right to Buy) $ 34.82 ( 2 )( 4 ) 03/09/2031 Common Stock 30,000 D Stock Option (Right to Buy) $ 7 ( 2 )( 5 ) 03/09/2032 Common Stock 90,000 D Stock Option (Right to Buy) $ 8 ( 2 )( 6 ) 01/04/2033 Common Stock 61,000 D Stock Option (Right to Buy) $ 10.56 ( 2 )( 7 ) 01/04/2034 Common Stock 90,000 D Stock Option (Right to Buy) $ 13.22 ( 2 )( 8 ) 01/09/2035 Common Stock 79,000 D Restricted Stock Unit ( 10 ) ( 9 ) ( 9 ) Common Stock 20,000 D Restricted Stock Unit ( 10 ) ( 11 ) ( 11 ) Common Stock 53,000 D

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other Hollywood Mark C/O ZYMEWORKS INC. 108 PATRIOT DRIVE, SUITE A MIDDLETOWN, DE19709 EVP & Chief Operating Officer Signatures /s/ Daniel Dex, Attorney-in-Fact 01/13/2026 Signature of Reporting Person Date

Explanation of Responses:

( 1 )Stock option granted March 27, 2019. ( 2 )Stock options vest as follows: (i) 25% of underlying shares of common stock on first anniversary of grant date and (ii) remainder of underlying shares of common stock in 36 equal monthly installments on last day of month following first anniversary of grant date. ( 3 )Stock option granted March 10, 2020. ( 4 )Stock option granted March 10, 2021. ( 5 )Stock option granted March 10, 2022. ( 6 )Stock option granted January 5, 2023. ( 7 )Stock option granted January 5, 2024. ( 8 )Stock option granted January 10, 2025. ( 9 )60,000 restricted stock units ("RSUs") granted January 5, 2024; vest in three equal annual installments beginning January 5, 2025. As of January 9, 2026, 20,000 RSUs remain outstanding. ( 10 )Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of common stock. ( 11 )53,000 restricted stock units ("RSUs") granted January 10, 2025; vest in three equal annual installments beginning January 10, 2026. As of January 9, 2026, 53,000 RSUs remain outstanding.

Remarks: Exhibit List - Exhibit 24 - Power of Attorney

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).

** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.