Sec Form 4 Filing - WELCH DANIEL G @ Structure Therapeutics Inc. - 2023-08-03

FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person WELCH DANIEL G 2. Issuer Name and Ticker or Trading Symbol Structure Therapeutics Inc. [ GPCR] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) X __ Director _____ 10% Owner _____ Officer (give title below) _____ Other (specify below) (Last) (First) (Middle) C/O STRUCTURE THERAPEUTICS INC., 611 GATEWAY BLVD., SUITE 223 3. Date of Earliest Transaction (MM/DD/YY) 08/03/2023 (Street) SOUTH SAN FRANCISCO, CA94080 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) __ X __ Form filed by One Reporting Person _____ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares Stock option (right to buy) $ 2.6 08/03/2023 J( 1 ) 411,000 ( 2 ) 01/19/2032 Ordinary Shares 411,000 $ 7.97 ( 1 ) 768,122 D Stock option (right to buy) $ 2.6 08/03/2023 J( 1 ) 205,500 ( 2 ) 01/19/2032 Ordinary Shares 205,500 $ 7.97 ( 1 ) 205,500 I By Trust ( 3 ) Stock option (right to buy) $ 2.6 08/03/2023 J( 1 ) 205,500 ( 2 ) 01/19/2032 Ordinary Shares 205,500 $ 7.97 ( 1 ) 205,500 I By Trust ( 4 )

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other WELCH DANIEL G C/O STRUCTURE THERAPEUTICS INC. 611 GATEWAY BLVD., SUITE 223 SOUTH SAN FRANCISCO, CA94080 X Signatures /s/ Jun Yoon, Attorney-in-Fact 08/04/2023 Signature of Reporting Person Date

Explanation of Responses:

( 1 )The reported transactions involve the Reporting Person's transfer of the vested portion of his option to trusts established for the benefit of hischildren. The transfer was a substitution for minority interests in a family limited partnership of equivalent value previously gifted to the trusts. The price per share is 1/3 of the closing price of the Issuer's American Depositary Shares ("ADS") on the date of transfer less the exercise price per share of the option. Each ADS consist of three of the Issuer's ordinary shares. ( 2 )1/3rd of the shares vested one year after January 5, 2022 (the "Vesting Commencement Date"); the balance of the shares vest in a series of 24 successive equal monthly installments measured from the first anniversary of the Vesting Commencement Date. ( 3 )The option is held by the Andrew J. Welch 2020 Irrevocable GST Trust, dated July 1, 2020. The Reporting Person is trustee of such trust and his son is the sole beneficiary of such trust. ( 4 )The option is held by the Michael D. Welch 2020 Irrevocable GST Trust, dated July 1, 2020. The Reporting Person is trustee of such trust and his son and such son's descendants are the sole beneficiaries of such trust.

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