Sec Form 4 Filing - Boxer Capital, LLC @ Tyra Biosciences, Inc. - 2021-09-17

FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person Boxer Capital, LLC 2. Issuer Name and Ticker or Trading Symbol Tyra Biosciences, Inc. [ TYRA] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director X __ 10% Owner _____ Officer (give title below) _____ Other (specify below) (Last) (First) (Middle) 12860 EL CAMINO REAL, SUITE 300, 3. Date of Earliest Transaction (MM/DD/YY) 09/17/2021 (Street) SAN DIEGO, CA92130 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) _____ Form filed by One Reporting Person __ X __ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 09/17/2021 C 5,698,359 A 5,698,359 D ( 2 ) Common Stock 09/17/2021 P 625,000 A $ 16 6,323,359 D ( 2 ) Common Stock 09/17/2021 C 288,095 A 288,095 D ( 3 )

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares Series A Preferred Stock ( 1 ) 09/17/2021 C 1,480,242 ( 1 ) ( 1 ) Common Stock 3,844,780 $ 0 0 D ( 2 ) Series A Preferred Stock ( 1 ) 09/17/2021 C 95,516 ( 1 ) ( 1 ) Common Stock 248,093 $ 0 0 D ( 3 ) Series B Preferred Stock ( 1 ) 09/17/2021 C 713,629 ( 1 ) ( 1 ) Common Stock 1,853,579 $ 0 0 D ( 2 ) Series B Preferred Stock ( 1 ) 09/17/2021 C 15,401 ( 1 ) ( 1 ) Common Stock 40,002 $ 0 0 D ( 3 )

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other Boxer Capital, LLC 12860 EL CAMINO REAL, SUITE 300 SAN DIEGO, CA92130 X Boxer Asset Management Inc. C/O CAY HOUSE P.O. BOX N-7776 E.P. TAYLOR DRIVE LYFORD CAY NEW PROVIDENCE, C5N7776 X LEWIS JOSEPH C/O CAY HOUSE P.O. BOX N-7776 E.P. TAYLOR DRIVE LYFORD CAY NEW PROVIDENCE, C5 X MVA Investors, LLC 12860 EL CAMINO REAL, SUITE 300 SAN DIEGO, CA92130 X Davis Aaron I. 12860 EL CAMINO REAL, SUITE 300 SAN DIEGO, CA92130 X Signatures Boxer Capital, LLC, By: /s/ Aaron I. Davis, Aaron I. Davis, Chief Executive Officer 09/17/2021 Signature of Reporting Person Date Boxer Asset Management Inc., By: /s/ Jason C. Callender, Jason C. Callender, Director 09/17/2021 Signature of Reporting Person Date /s/ Joseph C. Lewis 09/17/2021 Signature of Reporting Person Date MVA Investors, LLC, By: /s/ Aaron I. Davis, Aaron I. Davis, Chief Executive Officer 09/17/2021 Signature of Reporting Person Date /a/ Aaron I. Davis 09/17/2021 Signature of Reporting Person Date

Explanation of Responses:

( 1 )On September 17, 2021, each share of Series A Preferred Stock and each share of Series B Preferred Stock converted into shares of the Issuer's common stock at a ratio of 1-for-2.5974 without payment of further consideration upon closing of the initial public offering of the Issuer's common stock. The shares had no expiration date. ( 2 )These securities are held directly by Boxer Capital, LLC ("Boxer Capital"), which may be deemed to be a member of a "group" for purposes of Section 13(d) of the Securities Exchange Act of 1934, as amended, consisting of (i) Boxer Capital, (ii) Boxer Asset Management Inc. ("Boxer Management"), (iii) Joseph C. Lewis, (iv) MVA Investors, LLC and (v) Aaron I. Davis (collectively, the "Boxer Group"), and indirectly by Boxer Management and Joseph C. Lewis by virtue of their ownership in Boxer Capital. Each member of the Boxer Group other than Boxer Capital disclaims beneficial ownership of these securities to the extent it or he does not have a pecuniary interest therein. ( 3 )These securities are held directly by MVA Investors, which may be deemed to be a member of the Boxer Group for purposes of Section 13(d) of the Securities Exchange Act of 1934, as amended, and indirectly by Mr. Davis who is a member of and has voting and dispositive power over securities held by MVA Investors. Each member of the Boxer Group other than MVA Investors disclaims beneficial ownership of these securities to the extent it or he does not have a pecuniary interest therein.

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