Sec Form 4 Filing - Subramaniam Somu @ Ventyx Biosciences, Inc. - 2023-06-06

FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person Subramaniam Somu 2. Issuer Name and Ticker or Trading Symbol Ventyx Biosciences, Inc. [ VTYX] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) X __ Director X __ 10% Owner _____ Officer (give title below) _____ Other (specify below) (Last) (First) (Middle) C/O VENTYX BIOSCIENCES, INC., ENCINITAS BLVD, SUITE 250 3. Date of Earliest Transaction (MM/DD/YY) 06/06/2023 (Street) ENCINITAS, CA92024 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) __ X __ Form filed by One Reporting Person _____ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 06/06/2023 S 4,128 D $ 35.0003 ( 1 ) 9,872,917 I See Footnotes ( 2 ) ( 3 ) ( 4 ) ( 5 ) ( 6 ) Common Stock 06/07/2023 S 25,801 D $ 35.4846 ( 7 ) 9,847,116 I See Footnotes ( 4 ) ( 5 ) ( 6 ) ( 9 ) ( 10 ) Common Stock 06/07/2023 S 10,071 D $ 36.1007 ( 8 ) 9,837,045 I See Footnotes ( 4 ) ( 5 ) ( 6 ) ( 9 ) ( 10 )

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other Subramaniam Somu C/O VENTYX BIOSCIENCES, INC. ENCINITAS BLVD, SUITE 250 ENCINITAS, CA92024 X X Signatures /s/ Christopher Krueger, as Attorney-in-Fact 06/08/2023 Signature of Reporting Person Date

Explanation of Responses:

( 1 )Represents the weighted average share price of an aggregate total of 4,128 shares sold in the price range of $35.00 to $35.02. The reporting owner undertakes to provide upon request by the Commission staff, the issuer or a security holder of the issuer, full information regarding the number of shares sold at each separate price. ( 2 )Consists of: (i) 5,286,971 shares held by NSV Investments I, LP, (ii) 1,037,831 shares held by NSV Investments III, LP, (iii) 374,756 shares held by NSV Master Limited Partnership II, LP, (iv) 352,151 shares held by NSV 2019 Opportunities Fund, LP, (v) 304,170 shares held by NSV 2018 New Horizons Fund, LP, (vi) 330,816 shares held by Life & Tech, (vii) 434,423 shares held by New Science Ventures, LLC, (viii) 967,609 shares held by NSV Partners III, LP, (ix) 279,748 shares held by NSV Investments II, LP, (x) 296,359 shares held by NSV Partners II, LLC, (xi) 53,918 shares held by NSV Growth Opportunities Fund, LP, (xii) 45,191 shares held by New Science Ventures Fund III, LP, (xiii) 39,719 shares held by NSV 2017 Opportunities Fund, LP, (xiv) 27,696 shares held by NSV 2018 Opportunities Fund, LP, (xv) 21,421 shares held by NSV 2016 Opportunities Fund, LP, ( 3 )(Continued from Footnote 2) (xvi) 14,247 shares held by New Science Ventures Fund III (Offshore), LP, and (xvii) 5,891 shares held by NSV 2016 Opportunities Fund (Offshore), LP (collectively, the "NSV Funds"). The NSV Funds disclaim beneficial ownership over the shares owned by them, except to the extent of their pecuniary interest therein. ( 4 )NSV Partners III, LP is the general partner of NSV 2018 New Horizons Fund LP, NSV Investments I, LP, NSV 2018 Opportunities Fund, LP, NSV 2019 Opportunities Fund, LP, NSV Growth Opportunities Fund, LP, NSV Investments III, LP, and NSV Investments II, LP. ( 5 )NSV Partners II, LLC is the general partner of New Science Ventures Fund III, LP, New Science Ventures Fund III (Offshore), LP, NSV 2016 Opportunities Fund, LP, NSV 2016 Opportunities Fund (Offshore), LP, NSV 2017 Opportunities Fund, LP, and NSV Master Limited Partnership II, LP. ( 6 )The Reporting Person is the majority member and managing member of NSV Partners III GP, LLC, and may be deemed to have voting and dispositive power over the shares owned by each entity of which NSV Partners III, LP is general partner. The Reporting Person is the majority member and managing member NSV Partners II, LLC, and may be deemed to have voting and dispositive power over the shares owned by each entity of which NSV Partners II, LLC is general partner. The Reporting Person is the majority member and managing member of NSV Management, LLC, and may be deemed to share voting and dispositive power over the shares held by Life & Tech, for which NSV Management, LLC is the investment advisor. The Reporting Person disclaims beneficial ownership over the shares owned by each of the NSV Funds, except to the extent of his pecuniary interest therein. ( 7 )Represents the weighted average share price of an aggregate total of 25,801 shares sold in the price range of $35.00 to $35.99. The reporting owner undertakes to provide upon request by the Commission staff, the issuer or a security holder of the issuer, full information regarding the number of shares sold at each separate price. ( 8 )Represents the weighted average share price of an aggregate total of 10,071 shares sold in the price range of $36.00 to $36.125. The reporting owner undertakes to provide upon request by the Commission staff, the issuer or a security holder of the issuer, full information regarding the number of shares sold at each separate price. ( 9 )Consists of: (i) 5,286,971 shares held by NSV Investments I, LP, (ii) 1,037,831 shares held by NSV Investments III, LP, (iii) 374,756 shares held by NSV Master Limited Partnership II, LP, (iv) 347,792 shares held by NSV 2019 Opportunities Fund, LP, (v) 296,821 shares held by NSV 2018 New Horizons Fund, LP, (vi) 330,816 shares held by Life & Tech, (vii) 434,423 shares held by New Science Ventures, LLC, (viii) 967,609 shares held by NSV Partners III, LP, (ix) 279,748 shares held by NSV Investments II, LP, (x) 296,359 shares held by NSV Partners II, LLC, (xi) 53,466 shares held by NSV Growth Opportunities Fund, LP, (xii) 38,240 shares held by New Science Ventures Fund III, LP, (xiii) 33,610 shares held by NSV 2017 Opportunities Fund, LP, (xiv) 23,436 shares held by NSV 2018 Opportunities Fund, LP, ( 10 )(Continued from Footnote 9) (xv) 18,126 shares held by NSV 2016 Opportunities Fund, LP, (xvi) 12,056 shares held by New Science Ventures Fund III (Offshore), LP, and (xvii) 4,985 shares held by NSV 2016 Opportunities Fund (Offshore), LP. The NSV Funds disclaim beneficial ownership over the shares owned by them, except to the extent of their pecuniary interest therein.

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

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