Sec Form 3 Filing - WuXi AppTec Co., Ltd. @ Ambrx Biopharma Inc. - 2023-01-01

FORM 3 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL OMB Number: 3235-0287 Expires: November 30, 2011 Estimated average burden hours per response... 0.5

1. Name and Address of Reporting Person WuXi AppTec Co., Ltd. 2. Issuer Name and Ticker or Trading Symbol Ambrx Biopharma Inc. [ AMAM] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director X __ 10% Owner _____ Officer (give title below) _____ Other (specify below) (Last) (First) (Middle) 288 FUTE ZHONG ROAD, PUDONG NEW AREA 3. Date of Earliest Transaction (MM/DD/YY) 01/01/2023 (Street) SHANGHAI, F4200131 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) _____ Form filed by One Reporting Person __ X __ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Ordinary Shares( 1 ) 21,270,767 I Held by WuXi PharmaTech Healthcare Fund I, L.P.( 2 ) Ordinary Shares( 1 ) 7,996,920 I Held by WuXi AppTec (Hong Kong) Holding Limited( 3 )

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other WuXi AppTec Co., Ltd. 288 FUTE ZHONG ROAD PUDONG NEW AREA SHANGHAI, F4200131 X WuXi PharmaTech Healthcare Fund I L.P. 288 FUTE ZHONG ROAD PUDONG NEW AREA SHANGHAI, F4200131 X WuXi AppTec (Hong Kong) Holding Ltd 288 FUTE ZHONG ROAD PUDONG NEW AREA SHANGHAI, F4200131 X Signatures WuXi AppTec Co., Ltd., By: /s/ Edward Hu, Director 01/06/2023 Signature of Reporting Person Date WuXi PharmaTech Healthcare Fund I, L.P., By: /s/ Edward Hu, Director 01/06/2023 Signature of Reporting Person Date WuXi AppTec (Hong Kong) Holding Limited, By: /s/ Edward Hu, Director 01/06/2023 Signature of Reporting Person Date

Explanation of Responses:

( 1 )The Ordinary Shares of the Issuer may be represented by American Depositary Shares ("ADSs"). Each ADS represents seven Ordinary Shares of the Issuer. ( 2 )Shares are directly held by WuXi PharmaTech Healthcare Fund I, L.P. ("PharmaTech"). PharmaTech is an indirect, wholly owned subsidiary of WuXi AppTec Co., Ltd. ("AppTec Co"), which is the ultimate beneficial owner of PharmaTech and shares voting and investment authority over these shares. ( 3 )Shares are directly held by WuXi AppTec (Hong Kong) Holding Limited ("AppTec HK"). AppTec HK is an indirect, wholly owned subsidiary of AppTec Co, which is the ultimate beneficial owner of AppTec HK and shares voting and investment authority over these shares.

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).

** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.