Sec Form 4 Filing - Versant Venture Capital VI, L.P. @ Monte Rosa Therapeutics, Inc. - 2021-06-28

FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person Versant Venture Capital VI, L.P. 2. Issuer Name and Ticker or Trading Symbol Monte Rosa Therapeutics, Inc. [ GLUE] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director X __ 10% Owner _____ Officer (give title below) _____ Other (specify below) (Last) (First) (Middle) ONE SANSOME STREET, SUITE 3630 3. Date of Earliest Transaction (MM/DD/YY) 06/28/2021 (Street) SAN FRANCISCO, CA94104 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) _____ Form filed by One Reporting Person __ X __ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 06/28/2021 C 6,515,869 A 6,799,115 D ( 2 ) Common Stock 06/28/2021 C 1,940,043 A 1,940,043 I By Versant Vantage I, L.P. ( 3 ) Common Stock 06/28/2021 P 157,895 A $ 19 2,097,938 I By Versant Vantage I, L.P. ( 3 )

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares Series A convertible preferred stock ( 1 ) 06/28/2021 C 20,004,280 ( 1 ) ( 1 ) Common Stock 5,666,131 ( 1 ) 0 D ( 2 ) Series B convertible preferred stock ( 1 ) 06/28/2021 C 3,000,000 ( 1 ) ( 1 ) Common Stock 849,738 ( 1 ) 0 D ( 2 ) Series B convertible preferred stock ( 1 ) 06/28/2021 C 4,150,000 ( 1 ) ( 1 ) Common Stock 1,175,470 ( 1 ) 0 I By Versant Vantage I, L.P. ( 3 ) Series C convertible preferred stock ( 1 ) 06/28/2021 C 2,699,328 ( 1 ) ( 1 ) Common Stock 764,573 ( 1 ) 0 I By Versant Vantage I, L.P. ( 3 )

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other Versant Venture Capital VI, L.P. ONE SANSOME STREET, SUITE 3630 SAN FRANCISCO, CA94104 X Versant Ventures VI GP, L.P. ONE SANSOME STREET, SUITE 3630 SAN FRANCISCO, CA94104 X Versant Ventures VI GP-GP, LLC ONE SANSOME STREET, SUITE 3630 SAN FRANCISCO, CA94104 X Versant Vantage I, L.P. ONE SANSOME STREET, SUITE 3630 SAN FRANCISCO, CA94104 X Versant Vantage I GP, L.P. ONE SANSOME STREET, SUITE 3630 SAN FRANCISCO, CA94104 X Versant Vantage I GP-GP, LLC ONE SANSOME STREET, SUITE 3630 SAN FRANCISCO, CA94104 X Signatures Versant Venture Capital VI, L.P. By: Versant Ventures VI GP, L.P. Its: General Partner By: Versant Ventures VI GP-GP, LLC By: /s/ Robin L. Praeger Its: Managing Director 06/30/2021 Signature of Reporting Person Date Versant Ventures VI GP, L.P., By: Versant Ventures VI GP-GP, LLC By: /s/ Robin L. Praeger Its: Managing Director 06/30/2021 Signature of Reporting Person Date Versant Ventures VI GP-GP, LLC By: /s/ Robin L. Praeger Its: Managing Director 06/30/2021 Signature of Reporting Person Date Versant Vantage I, LP By: Versant Vantage I GP, L.P. Its: General Partner By: Versant Vantage I GP-GP, LLC Its: General Partner By: /s/ Robin L. Praeger Its: Managing Director 06/30/2021 Signature of Reporting Person Date Versant Vantage I GP, L.P., By: Versant Vantage I GP-GP, LLC Its: General Partner By: /s/ Robin L. Praeger Its: Managing Director 06/30/2021 Signature of Reporting Person Date Versant Vantage I GP-GP, LLC, By: /s/ Robin L. Praeger Its: Managing Director 06/30/2021 Signature of Reporting Person Date

Explanation of Responses:

( 1 )Each share of Series A convertible preferred stock, Series B convertible preferred stock and Series C convertible preferred stock (collectively, the "Preferred Stock") was convertible at any time at the holder's election and automatically upon the closing of the Issuer's initial public offering. The Preferred Stock converted into Common Stock on a 3.5305-for-one basis upon the closing of the Issuer's initial public offering without payment or additional consideration. The Preferred Stock had no expiration date. ( 2 )Shares held by Versant Venture Capital VI, L.P. ("Versant VI"). Versant Ventures VI GP, L.P. ("Versant Ventures VI GP") is the general partner of Versant VI, and Versant Ventures VI GP-GP, LLC ("Versant Ventures VI GP GP") is the general partner of Versant Ventures VI GP. Bradley J. Bolzon, a member of the Issuer's board of directors, is a managing member of Versant Ventures VI GP-GP and may be deemed to share voting and dispositive power over the shares held by Versant VI. Each of Versant Ventures VI GP, Versant Ventures VI GP-GP and Bradley J. Bolzon disclaim beneficial ownership of such securities, except to the extent of their pecuniary interests therein. Bradley J. Bolzon is a director of the Issuer and, accordingly, files separate Section 16 reports ( 3 )Shares held by Versant Vantage I, L.P. ("Versant Vantage I"). Versant Vantage I GP, L.P. ("Versant Vantage I GP") is the general partner of Versant Vantage I, and Versant Vantage I GP-GP, LLC ("Versant Vantage I GP-GP") is the general partner of Versant Vantage I GP. Bradley J. Bolzon is a managing member of Versant Vantage I GP-GP and may be deemed to share voting and dispositive power over the shares held by Versant Vantage I. Each of Versant Vantage I GP, Versant Vantage I GP-GP and Bradley J. Bolzo n disclaim beneficial ownership of such securities, except to the extent of their respective pecuniary interests therein. Bradley J. Bolzon is a director of the Issuer and, accordingly, files separate Section 16 reports.

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

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