Sec Form 4 Filing - Zaranek Mike @ Science 37 Holdings, Inc. - 2023-04-28

FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person Zaranek Mike 2. Issuer Name and Ticker or Trading Symbol Science 37 Holdings, Inc. [ SNCE] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director _____ 10% Owner X __ Officer (give title below) _____ Other (specify below) Chief Financial Officer (Last) (First) (Middle) 800 PARK OFFICES DRIVE, SUITE 3606 3. Date of Earliest Transaction (MM/DD/YY) 04/28/2023 (Street) RESEARCH TRIANGLE PARK, NC27709 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) __ X __ Form filed by One Reporting Person _____ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 04/28/2023 A 444,283 A 444,283 ( 4 ) D

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares Stock Option $ 9.06 04/28/2023 D 457,466 ( 5 ) ( 1 ) 06/13/2031 Common Stock 457,466 ( 1 ) 0 D Stock Option $ 11.47 04/28/2023 D 185,897 ( 2 ) 01/07/2032 Common Stock 185,897 ( 2 ) 0 D Stock Option $ 10.05 04/28/2023 D 467,351 ( 3 ) 10/07/2031 Common Stock 467,351 ( 3 ) 0 D

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other Zaranek Mike 800 PARK OFFICES DRIVE, SUITE 3606 RESEARCH TRIANGLE PARK, NC27709 Chief Financial Officer Signatures /s/ Christine Pellizzari, Attorney-in-Fact for Mike Zaranek 05/02/2023 Signature of Reporting Person Date

Explanation of Responses:

( 1 )On April 28, 2023, the issuer cancelled, pursuant to the issuer's option exchange program, options to purchase 457,466 shares of common stock of the issuer and in exchange issued to the reporting person 182,985 restricted stock units, each of which represents a contingent right to receive one share of the issuer's common stock. ( 2 )On April 28, 2023, the issuer cancelled, pursuant to the issuer's option exchange program, options to purchase 185,897 shares of common stock of the issuer and in exchange issued to the reporting person 74,358 restricted stock units, each of which represents a contingent right to receive one share of the issuer's common stock. ( 3 )On April 28, 2023, the issuer cancelled, pursuant to the issuer's option exchange program, options to purchase 467,351 shares of common stock of the issuer and in exchange issued to the reporting person 186,940 restricted stock units, each of which represents a contingent right to receive one share of the issuer's common stock. ( 4 )Includes 444,283 restricted stock units, which will vest in three equal annual installments beginning on April 28, 2024, subject to continued employment. ( 5 )The total amount has been adjusted to add 11 derivative securities that were not previously included due to a rounding error.

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).

** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

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