Sec Form 3 Filing - Lux Capital Management, LLC @ Science 37 Holdings, Inc. - 2021-10-06

FORM 3 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person Lux Capital Management, LLC 2. Issuer Name and Ticker or Trading Symbol Science 37 Holdings, Inc. [ SNCE] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director X __ 10% Owner _____ Officer (give title below) _____ Other (specify below) (Last) (First) (Middle) 920 BROADWAY, 11TH FLOOR, 3. Date of Earliest Transaction (MM/DD/YY) 10/06/2021 (Street) NEW YORK, NY10010 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) _____ Form filed by One Reporting Person __ X __ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 11,658,666 ( 1 ) I By Lux Ventures IV, L.P. ( 2 ) ( 3 ) Common Stock 3,505,890 ( 1 ) I By Lux Co-Invest Opportunities, L.P. ( 2 ) ( 3 )

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other Lux Capital Management, LLC 920 BROADWAY, 11TH FLOOR NEW YORK, NY10010 X Lux Ventures IV, L.P. C/O LUX CAPITAL MANAGEMENT, LLC 920 BROADWAY, 11TH FLOOR NEW YORK, NY10017 X Lux Venture Partners IV, LLC C/O LUX CAPITAL MANAGEMENT, LLC 920 BROADWAY, 11TH FLOOR NEW YORK, NY10010 X Lux Co-Invest Opportunities, L.P. C/O LUX CAPITAL MANAGEMENT, LLC 920 BROADWAY, 11TH FLOOR NEW YORK, NY10010 X Lux Co-Invest Partners, LLC C/O LUX CAPITAL MANAGEMENT, LLC 920 BROADWAY, 11TH FLOOR NEW YORK, NY10010 X Hebert Peter C/O LUX CAPITAL MANAGEMENT, LLC 920 BROADWAY, 11TH FLOOR NEW YORK, NY10010 X Wolfe Josh C/O LUX CAPITAL MANAGEMENT, LLC 920 BROADWAY, 11TH FLOOR NEW YORK, NY10010 X Signatures Lux Capital Management, LLC, By: /s/ Segolene Scarborough, Attorney-in-Fact for Peter Hebert, Managing Member 10/18/2021 Signature of Reporting Person Date Lux Ventures IV, L.P., By: /s/ Segolene Scarborough, Attorney-in-Fact for Peter Hebert, Managing Member 10/18/2021 Signature of Reporting Person Date Lux Venture Partners IV, LLC, By: /s/ Segolene Scarborough, Attorney-in-Fact for Peter Hebert, Managing Member 10/18/2021 Signature of Reporting Person Date Lux Co-Invest Opportunities, L.P., By: Lux Co-Invest Partners, LLC, its general partner, By: /s/ Peter Hebert, Name: Peter Herbert, Title: Manager 10/18/2021 Signature of Reporting Person Date Lux Co-Invest Partners, LLC, By: /s/ Segolene Scarborough, Attorney-in-Fact for Peter Hebert, Managing Member 10/18/2021 Signature of Reporting Person Date By: /s/ Segolene Scarborough, Attorney-in-Fact for Peter Hebert 10/18/2021 Signature of Reporting Person Date By: /s/ Segolene Scarborough, Attorney-in-Fact for Josh Wolfe 10/18/2021 Signature of Reporting Person Date

Explanation of Responses:

( 1 )On October 6, 2021, pursuant to that certain Agreement and Plan of Merger, dated as of May 6, 2021, by and among the Issuer (f/k/a LifeSci Acquisition II Corp.), LifeSci Acquisition II Merger Sub, Inc., Inc. ("Merger Sub"), and Science 37, Inc. ("Legacy Science 37"), Merger Sub merged with and into Legacy Science 37, with Legacy Science 37 surviving as a wholly owned subsidiary of the Issuer (the "Merger"). Immediately prior to the consummation of the Merger, each share of common stock of Legacy Science 37 was converted into the right to receive approximately 1.8153 shares of the Issuer's Common Stock. ( 2 )Lux Venture Partners IV, LLC is the general partner of Lux Ventures IV, L.P. and exercises voting and dispositive power over the shares held by Lux Ventures IV, L.P. Lux Co-Invest Partners, LLC is the general partner of Lux Co-Invest Opportunities, L.P. and exercises voting and dispositive power over the shares held by Lux Co-Invest Opportunities, L.P. Peter Hebert and Josh Wolfe are the sole managers of Lux Venture Partners IV, LLC and Lux Co-Invest Partners, LLC and may be deemed to share voting and dispositive power for the shares held by each of Lux Ventures IV, L.P. and Lux Co-Invest Opportunities, L.P. Lux Capital Management, LLC, as the investment manager for each of Lux Venture Partners IV, LLC and Lux Co-Invest Partners, LLC, may be deemed to share voting and investment powers for the shares held by each of Lux Ventures IV, L.P. and Lux Co-Invest Opportunities, L.P. ( 3 )Each of Lux Capital Management, LLC, Lux Venture Partners IV, LLC, Lux Co-Invest Partners, LLC, Peter Hebert and Josh Wolfe disclaim beneficial ownership over the shares reported herein except to the extent of their pecuniary interest therein.

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

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