Sec Form 4 Filing - George Simeon @ Nkarta, Inc. - 2024-03-27

FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL OMB Number: 3235-0287 Expires: November 30, 2011 Estimated average burden hours per response... 0.5

1. Name and Address of Reporting Person George Simeon 2. Issuer Name and Ticker or Trading Symbol Nkarta, Inc. [ NKTX] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) X __ Director _____ 10% Owner _____ Officer (give title below) _____ Other (specify below) (Last) (First) (Middle) 985 OLD EAGLE SCHOOL ROAD, SUITE 511 3. Date of Earliest Transaction (MM/DD/YY) 03/27/2024 (Street) WAYNE, PA19087 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) __ X __ Form filed by One Reporting Person _____ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 03/27/2024 P( 1 ) 1,548,341 A $ 10 1,548,341 I See Note 2 ( 2 ) Common Stock 03/27/2024 P( 1 ) 451,659 A $ 10 451,659 I See Note 3 ( 3 ) Common Stock 666,667 I See Note 4 ( 4 ) Common Stock 666,666 I See Note 5 ( 5 )

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transacti on(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other George Simeon 985 OLD EAGLE SCHOOL ROAD SUITE 511 WAYNE, PA19087 X Signatures /s/ Sasha Keough, attorney-in-fact for Simeon George 03/28/2024 Signature of Reporting Person Date

Explanation of Responses:

( 1 )Reports the purchase of shares in the underwritten public offering of common stock of the Issuer. ( 2 )The Reporting Person is the sole managing member of SR One Capital Management, LLC ("SR One Capital Management"), which is the sole general partner of SR One Capital Opportunities Partners I, LP ("SR One Opportunities Partners I"). SR One Opportunities Partners I is the sole general partner of SR One Capital Opportunities Fund I, LP ("SR One Opportunities Fund I"), which is the direct beneficial owner of the securities. The Reporting Person disclaims beneficial ownership, within the meaning of Section 16 or otherwise of such portion of the securities held by SR One Opportunities Fund I in which the Reporting Person has no pecuniary interest. ( 3 )The Reporting Person is the sole managing member of SR One Capital Management, which is the sole general partner of SR One Capital Partners II, LP ("SR One Partners II"). SR One Partners II is the sole general partner of SR One Capital Fund II Aggregator, LP ("SR One Fund II Aggregator"), which is the direct beneficial owner of the securities. The Reporting Person disclaims beneficial ownership, within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended ("Section 16"), or otherwise of such portion of the securities held by SR One Fund II Aggregator in which the Reporting Person has no pecuniary interest. ( 4 )The Reporting Person is the sole managing member of SR One Capital Management, which is the managing member of SR One Co-Invest IX Manager, LLC ("SR One Co-Invest IX Manager"). SR One Co-Invest IX Manager is the managing member of SR One Co-Invest IX, LLC ("SR One Co-Invest IX"), which is the direct beneficial owner of the securities. The Reporting Person disclaims beneficial ownership, within the meaning of Section 16 or otherwise of such portion of the securities held by SR One Co-Invest IX in which the Reporting Person has no pecuniary interest. ( 5 )The Reporting Person is the sole managing member of SR One Capital Management, which is the managing member of SR One Co-Invest X Manager, LLC ("SR One Co-Invest X Manager"). SR One Co-Invest X Manager is the managing member of SR One Co-Invest X, LLC, ("SR One Co-Invest X"), which is the direct beneficial owner of the securities. The Reporting Person disclaims beneficial ownership, within the meaning of Section 16 or otherwise of such portion of the securities held by SR One Co-Invest X in which the Reporting Person has no pecuniary interest.

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).

** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.