Sec Form 4 Filing - Kreis Leslie W. @ Lantern Pharma Inc. - 2022-03-17

FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person Kreis Leslie W. 2. Issuer Name and Ticker or Trading Symbol Lantern Pharma Inc. [ LTRN] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) X __ Director X __ 10% Owner _____ Officer (give title below) _____ Other (specify below) (Last) (First) (Middle) 1751 RIVER RUN, SUITE 400, 3. Date of Earliest Transaction (MM/DD/YY) 03/17/2022 (Street) FORT WORTH, TX76107 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) _____ Form filed by One Reporting Person __ X __ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 03/17/2022 X( 1 )( 2 )( 3 ) 60,432( 1 )( 2 )( 3 ) A $ 189,152.16( 1 )( 2 )( 3 ) 564,038 I Bios Fund I, LP( 1 )( 2 )( 5 ) Common Stock 03/17/2022 X( 1 )( 2 )( 4 ) 35,347( 1 )( 2 )( 4 ) A $ 110,636.11( 1 )( 2 )( 4 ) 329,904 I Bios Fund I QP, LP( 1 )( 2 )( 5 ) Common Stock 204,723 I Bios Fund II, LP( 1 )( 2 )( 5 ) Common Stock 668,738 I Bios Fund II QP, LP( 1 )( 2 )( 5 ) Common Stock 89,522 I Bios Fund II NT, LP( 1 )( 2 )( 5 )

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares Series A Warrants ( 3 ) 03/17/2022 X 60,432( 1 )( 2 )( 3 ) 03/17/2017 03/17/2022 Common Stock 60,432 ( 3 ) 0 I Bios Fund I, LP( 1 )( 2 )( 5 ) Series A Warrants ( 4 ) 03/17/2022 X 35,347( 1 )( 2 )( 4 ) 03/17/2017 03/17/2022 Common Stock 35,347 ( 4 ) 0 I Bios Fund I QP, LP( 1 )( 2 )( 5 )

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other Kreis Leslie W. 1751 RIVER RUN, SUITE 400 FORT WORTH, TX76107 X X Bios Equity Partners, LP 1751 RIVER RUN, SUITE 400 FORT WORTH, TX76107 X Cavu Management, LP 1751 RIVER RUN, SUITE 400 FORT WORTH, TX76107 X BIOS Capital Management, LP 1751 RIVER RUN SUITE 400 FORT WORTH, TX76107 X Cavu Advisors, LLC 1751 RIVER RUN, SUITE 400 FORT WORTH, TX76107 X BIOS Advisors GP, LLC 1751 RIVER RUN SUITE 400 FORT WORTH, TX76107 X Fletcher Aaron G.L. 1751 RIVER RUN SUITE 400 FT WORTH, TX76107 X BIOS Fund I, LP 1751 RIVER RUN, SUITE 400 FORT WORTH, TX76107 X BIOS Fund I QP, LP 1751 RIVER RUN, SUITE 400 FORT WORTH, TX76107 X Signatures /s/ Leslie W. Kreis, Jr. 03/21/2022 Signature of Reporting Person Date Bios Equity Partners, LP, By: Cavu Management, LP, its general partner, By: Cavu Advisors, LLC, its general partner, By: /s/ Leslie W. Kreis, Jr, Manager 03/21/2022 Signature of Reporting Person Date Cavu Management, LP, By: Cavu Advisors, LLC, its general partner, By: /s/ Leslie W. Kreis, Jr, Manager 03/21/2022 Signature of Reporting Person Date Bios Capital Management, LP, By: Bios Advisors GP, LLC, its general partner, By /s/ Aaron Glenn Louis Fletcher, Manager 03/21/2022 Signature of Reporting Person Date Cavu Advisors, LLC, By: /s/ Leslie W. Kreis, Jr, Manager 03/21/2022 Signature of Reporting Person Date Bios Advisors GP, LLC, By: /s/ Aaron Glenn Louis Fletcher, Manager 03/21/2022 Signature of Reporting Person Date /s/ Aaron Glenn Louis Fletcher 03/21/2022 Signature of Reporting Person Date Bios Fund I, LP, By: Bios Equity Partners, LP, its general partne r, By: Cavu Management, LP, its general partner, By: Cavu Advisors, LLC, its general partner, By: /s/ Leslie W. Kreis, Jr, Manager 03/21/2022 Signature of Reporting Person Date Bios Fund I QP, LP, By: Bios Equity Partners, LP, its general partner, By: Cavu Management, LP, its general partner, By: Cavu Advisors, LLC, its general partner, By: /s/ Leslie W. Kreis, Jr, Manager 03/21/2022 Signature of Reporting Person Date

Explanation of Responses:

( 1 )Bios Equity Partners, LP ("Bios Equity I") is the general partner of the following entities: Bios Fund I, LP ("Bios Fund I") and Bios Fund I QP, LP ("Bios Fund I QP"). Bios Equity Partners II, LP ("Bios Equity II") is the general partner of the following entities: Bios Fund II, LP ("Bios Fund II"), Bios Fund II QP, LP ("Bios Fund II QP") and Bios Fund II NT, LP ("Bios Fund II NT"). Cavu Management, LP ("Cavu Management"), an entity managed and controlled by Mr. Kreis, and Bios Capital Management, LP ("Bios Management"), an entity managed and controlled by Aaron Glenn Louis Fletcher, are each a general partner of Bios Equity I and Bios Equity II. Cavu Advisors LLC ("Cavu Advisors"), an entity that is managed and controlled by Mr. Kreis, is the general partner of Cavu Management. Bios Advisors GP, LLC ("Bios Advisors"), an entity that is managed and controlled by Mr. Fletcher, is the general partner of Bios Management. ( 2 )Mr. Kreis, Cavu Management, Cavu Advisors, Mr. Fletcher, Bios Management and Bios Advisors each share voting and investment control with respect to the shares held by Bios Fund I, Bios Fund I QP, Bios Fund II, Bios Fund II QP and Bios Fund II NT (collectively, the "Bios Equity Entities"). Because of the relationship between Mr. Kreis, Mr. Fletcher, Cavu Management, Bios Management, Cavu Advisors, Bios Advisors and the Bios Equity Entities, Mr. Kreis, Mr. Fletcher, Cavu Management, Bios Management, Cavu Advisors and Bios Advisors each may be deemed to beneficially own the shares held directly by the Bios Equity Entities. ( 3 )Bios Fund I exercised warrants to purchase 60,432 shares of common stock at an exercise price of $3.13 per share. ( 4 )Bios Fund I QP exercised warrants to purchase 35,347 shares of common stock at an exercise price of $3.13 per share. ( 5 )For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise.

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).

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