Sec Form 4 Filing - ALEXANDRIA REAL ESTATE EQUITIES, INC. @ Applied Therapeutics Inc. - 2021-02-17

FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person ALEXANDRIA REAL ESTATE EQUITIES, INC. 2. Issuer Name and Ticker or Trading Symbol Applied Therapeutics Inc. [ APLT] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director X __ 10% Owner _____ Officer (give title below) _____ Other (specify below) (Last) (First) (Middle) 26 NORTH EUCLID AVENUE 3. Date of Earliest Transaction (MM/DD/YY) 02/17/2021 (Street) PASADENA, CA91101 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) _____ Form filed by One Reporting Person __ X __ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 02/17/2021 P 43,478 A $ 23 1,287,455 I By subsidiary ( 1 ) Common Stock 02/17/2021 J 43,478 ( 2 ) D 1,243,977 I By subsidiary ( 1 ) Common Stock 02/17/2021 J 43,478 ( 2 ) A 2,190,077 I By subsidiary ( 3 )

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other ALEXANDRIA REAL ESTATE EQUITIES, INC. 26 NORTH EUCLID AVENUE PASADENA, CA91101 X Alexandria Equities No. 7, LLC 26 NORTH EUCLID AVENUE PASADENA, CA91101 X Alexandria Venture Investments, LLC 26 NORTH EUCLID AVENUE PASADENA, CA91101 X Signatures ALEXANDRIA EQUITIES NO. 7, LLCBy: ARE-Special Services, LLC, managing memberBy: ALEXANDRIA REAL ESTATE EQUITIES, L.P., managing memberBy: ARE-QRS CORP., general partnerBy: /s/ Dean A. Shigenaga, Chief Financial Officer 02/18/2021 Signature of Reporting Person Date By: /s/ Dean A. ShigenagaChief Financial OfficerALEXANDRIA EQUITIES NO. 7, LLCBy: ARE-Special Services, LLC, managing member 02/18/2021 Signature of Reporting Person Date By: ALEXANDRIA REAL ESTATE EQUITIES, L.P., managing memberBy: ARE-QRS CORP., general partnerBy: /s/ Dean A. Shigenaga, Chief Financial Officer 02/18/2021 Signature of Reporting Person Date

Explanation of Responses:

( 1 )These shares are held directly by Alexandria Equities No. 7, LLC ("AE7"), a wholly owned subsidiary of Alexandria Real Estate Equities, Inc. ( 2 )These shares have been transferred from AE7 to Alexandria Venture Investments, LLC ("AVI") upon acquisition, an affiliate of AE7 and another wholly owned subsidiary of Alexandria Real Estate Equities, Inc. ( 3 )These shares are held directly by AVI.

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).

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