Sec Form 4 Filing - Rudisill McAndrew @ 180 Life Sciences Corp. - 2025-08-08

FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person Rudisill McAndrew 2. Issuer Name and Ticker or Trading Symbol 180 Life Sciences Corp. [ ATNF] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) X __ Director _____ 10% Owner _____ Officer (give title below) X __ Other (specify below) Executive Chairman (Last) (First) (Middle) 3000 EL CAMINO REAL, BLDG. 4,, SUITE 200 3. Date of Earliest Transaction (MM/DD/YY) 08/08/2025 (Street) PALO ALTO, CA94306 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) __ X __ Form filed by One Reporting Person _____ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 37,735 I By BER I LLC ( 1 ) Common Stock 37,735 I By GER I LLC ( 2 ) Common Stock 37,735 I By MRR I LLC ( 3 ) Common Stock 452,830 I By Pelagic Capital Advisors LLC ( 4 )

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares Warrant to Purchase Common Stock $ 2.775 08/04/2025( 5 ) ( 6 ) Common Stock 4,807,873 4,807,873 I By PCAO LLC ( 8 ) Warrant to Purchase Common Stock $ 3.445 08/08/2025 A 957,002 08/08/2025( 5 ) ( 6 ) Common Stock 957,002 $ 0 ( 7 ) 957,002 I By PCAO LLC ( 8 )

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other Rudisill McAndrew 3000 EL CAMINO REAL, BLDG. 4, SUITE 200 PALO ALTO, CA94306 X Executive Chairman Signatures /s/ McAndrew Rudisill 08/12/2025 Signature of Reporting Person Date

Explanation of Responses:

( 1 )The Reporting Person is the managing partner of BER I LLC ("BER"), and therefore may be deemed to beneficially own the securities held by BER. Mr. Rudisill disclaims beneficial ownership of the shares of common stock owned directly by BER, except to the extent of his pecuniary interest therein and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of the securities for purposes of Section 16 or for any other purpose. ( 2 )The Reporting Person is the managing partner of GER I LLC ("GER"), and therefore may be deemed to beneficially own the securities held by GER. Mr. Rudisill disclaims beneficial ownership of the shares of common stock owned directly by GER, except to the extent of his pecuniary interest therein and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of the securities for purposes of Section 16 or for any other purpose. ( 3 )The Reporting Person is the managing partner of MRR I LLC ("MRR"), and therefore may be deemed to beneficially own the securities held by MRR. Mr. Rudisill disclaims beneficial ownership of the shares of common stock owned directly by MRR, except to the extent of his pecuniary interest therein and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of the securities for purposes of Section 16 or for any other purpose. ( 4 )The Reporting Person is the managing partner and founder of Pelagic Capital Advisors LLC ("Pelagic"), and therefore may be deemed to beneficially own the securities held by Pelagic. Mr. Rudisill disclaims beneficial ownership of the shares of common stock owned directly by Pelagic, except to the extent of his pecuniary interest therein and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of the securities for purposes of Section 16 or for any other purpose. ( 5 )These warrants are currently exercisable, subject to a blocker provision that prevents PCAO (defined below) from exercising the warrants if it would be more than a 4.99% beneficial owner of the outstanding shares of the Issuer's common stock following such exercise, which percentage may be increased to up to 19.99% with at least 61 days prior written notice to the Issuer. ( 6 )The warrants have no expiration date. ( 7 )Issued in consideration for advisory and consulting services agreed to be rendered by PCAO. ( 8 )The Reporting Person is the managing partner of PCAO LLC ("PCAO"), and therefore may be deemed to beneficially own the securities held by such entity. Mr. Rudisill disclaims beneficial ownership of the shares of securities owned directly by PCAO, except to the extent of his pecuniary interest therein and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of the securities for purposes of Section 16 or for any other purpose.

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).

** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

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