Sec Form 4 Filing - Stout Stephen @ Shattuck Labs, Inc. - 2024-03-06

FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person Stout Stephen 2. Issuer Name and Ticker or Trading Symbol Shattuck Labs, Inc. [ STTK] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director _____ 10% Owner X __ Officer (give title below) _____ Other (specify below) See Remarks (Last) (First) (Middle) C/O SHATTUCK LABS, INC., 500 W. 5TH STREET, SUITE 1200 3. Date of Earliest Transaction (MM/DD/YY) 03/06/2024 (Street) AUSTIN, TX78701 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) __ X __ Form filed by One Reporting Person _____ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 03/06/2024 M 4,650 A $ 3.51 83,982 D Common Stock 03/06/2024 S( 1 ) 4,650 D $ 10.53 79,332 D Common Stock 03/06/2024 M 6,459 A $ 3.57 85,791 D Common Stock 03/06/2024 S( 1 ) 6,459 D $ 10.53 79,332 D Common Stock 03/06/2024 S( 1 ) 4,895 D $ 10.53 74,437 D

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares Stock Option (Right to Buy) $ 3.51 03/06/2024 M 4,650 ( 2 ) 09/08/2032 Common Stock 4,650 $ 0 9,300 D Stock Option (Right to Buy) $ 3.57 03/06/2024 M 6,459 ( 3 ) 01/25/2033 Common Stock 6,459 $ 0 17,391 D

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other Stout Stephen C/O SHATTUCK LABS, INC. 500 W. 5TH STREET, SUITE 1200 AUSTIN, TX78701 See Remarks Signatures /s/ Stephen Stout 03/08/2024 Signature of Reporting Person Date

Explanation of Responses:

( 1 )Sale of shares effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 23, 2023. ( 2 )The stock option was granted to the Reporting Person on September 8, 2022, one-third of which vested on September 8, 2023 and the remaining two-thirds of which will vest on September 8, 2024. ( 3 )The stock option was granted to the Reporting Person on January 25, 2023, one-quarter of which vested on January 10, 2024 and the remaining three-quarters of which will vest in approximately equal monthly installments through January 10, 2027.

Remarks: General Counsel, Corporate Secretary and Chief Ethics and Compliance Officer

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).

** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

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