Sec Form 3 Filing - Stout Stephen @ Shattuck Labs, Inc. - 2023-03-23

FORM 3 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person Stout Stephen 2. Issuer Name and Ticker or Trading Symbol Shattuck Labs, Inc. [ STTK] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director _____ 10% Owner X __ Officer (give title below) _____ Other (specify below) See Remarks (Last) (First) (Middle) C/O SHATTUCK LABS, INC., 500 W. 5TH STREET, SUITE 1200 3. Date of Earliest Transaction (MM/DD/YY) 03/23/2023 (Street) AUSTIN, TX78701 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) __ X __ Form filed by One Reporting Person _____ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 14,975 ( 1 ) D

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares Stock Option (Right to Buy) $ 28.23 ( 2 ) 04/09/2031 Common Stock 14,300 D Stock Option (Right to Buy) $ 7.43 ( 3 ) 01/10/2032 Common Stock 34,875 D Stock Option (Right to Buy) $ 3.51 ( 4 ) 09/08/2032 Common Stock 13,950 D Stock Option (Right to Buy) $ 3.57 ( 5 ) 01/25/2033 Common Stock 23,850 D

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other Stout Stephen C/O SHATTUCK LABS, INC. 500 W. 5TH STREET, SUITE 1200 AUSTIN, TX78701 See Remarks Signatures /s/ Stephen Stout 03/31/2023 Signature of Reporting Person Date

Explanation of Responses:

( 1 )Consists of 14,975 restricted stock units ("RSUs"), 1,744 of which have vested. 5,231 RSUs will vest in three approximately equal annual installments beginning on January 10, 2024 and 8,000 RSUs will vest in four equal annual installments beginning on January 25, 2024, in each case subject to the Reporting Person's continued service to the Issuer. ( 2 )This option represents a right to purchase a total of 14,300 shares of the Issuer's common stock, 6,852 of which have vested, with the remaining vesting in approximately equal monthly installments through April 10, 2025, subject to the Reporting Person's continued service to the Issuer. ( 3 )This option represents a right to purchase a total of 34,875 shares of the Issuer's common stock, 10,172 of which have vested, with the remaining vesting in approximately equal monthly installments through January 10, 2026, subject to the Reporting Person's continued service to the Issuer. ( 4 )This option represents a right to purchase a total of 13,950 shares of the Issuer's common stock, one-third of which will vest on September 8, 2023 and two-thirds of which will vest on September 8, 2024, subject to the Reporting Person's continued service to the Issuer. ( 5 )This option represents a right to purchase a total of 23,850 shares of the Issuer's common stock, one-quarter of which will vest on January 25, 2024, with the remaining three-quarters vesting in approximately equal monthly installments through December 10, 2025, subject to the Reporting Person's continued service to the Issuer.

Remarks: Deputy General Counsel and Vice President of Intellectual PropertyExhibit 24 - Power of Attorney

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