Sec Form 4 Filing - Lynch Casey @ Cortexyme, Inc. - 2021-02-01

FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person Lynch Casey 2. Issuer Name and Ticker or Trading Symbol Cortexyme, Inc. [ CRTX] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) X __ Director _____ 10% Owner X __ Officer (give title below) _____ Other (specify below) Chief Executive Officer (Last) (First) (Middle) C/O CORTEXYME, INC., 269 EAST GRAND AVE. 3. Date of Earliest Transaction (MM/DD/YY) 02/01/2021 (Street) SOUTH SAN FRANCISCO, CA94080 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) __ X __ Form filed by One Reporting Person _____ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 02/01/2021 S( 1 ) 4,686 D $ 34.6 ( 2 ) 1,094,088 I By the Zachary and Casey Lynch Living Trust dated February 24, 2009 ( 3 ) Common Stock 02/01/2021 S( 1 ) 3,100 D $ 35.59 ( 4 ) 1,090,988 I By the Zachary and Casey Lynch Living Trust dated February 24, 2009 ( 3 ) Common Stock 02/01/2021 S( 1 ) 7,460 D $ 36.56 ( 5 ) 1,083,528 I By the Zachary and Casey Lynch Living Trust dated February 24, 2009 ( 3 ) Common Stock 02/01/2021 S( 1 ) 4,283 D $ 37.68 ( 6 ) 1,079,245 I By the Zachary and Casey Lynch Living Trust dated February 24, 2009 ( 3 ) Common Stock 02/01/2021 S( 1 ) 100 D $ 38.28 1,079,145 I By the Zachary and Casey Lynch Living Trust dated February 24, 2009 ( 3 ) Common Stock 02/01/2021 S( 1 ) 371 D $ 39.23 1,078,774 I By the Zachary and Casey Lynch Living Trust dated February 24, 2009 ( 3 ) Common Stock 02/02/2021 S( 1 ) 14,929 D $ 36.02 ( 7 ) 1,063,845 I By the Zachary and Casey Lynch Living Trust dated February 24, 2009 ( 3 ) Common Stock 02/02/2021 S( 1 ) 5,071 D $ 36.75 ( 8 ) 1,058,774 I By the Zachary and Casey Lynch Living Trust dated February 24, 2009 ( 3 ) Common Stock 02/03/2021 S( 1 ) 400 D $ 37.39 ( 9 ) 1,058,374 I By the Zachary and Casey Lynch Living Trust dated February 24, 2009 ( 3 ) Common Stock 02/03/2021 S( 1 ) 1,600 D $ 38.64 ( 10 ) 1,056,774 I By the Zachary and Casey Lynch Living Trust dated February 24, 2009 ( 3 ) Common Stock 02/03/2021 S( 1 ) 856 D $ 39.82 ( 11 ) 1,055,918 I By the Zachary and Casey Lynch Living Trust dated February 24, 2009 ( 3 ) Common Stock 02/03/2021 S( 1 ) 2,000 D $ 40.84 ( 12 ) 1,053,918 I By the Zachary and Casey Lynch Living Trust dated February 24, 2009 ( 3 ) Common Stock 02/03/2021 S( 1 ) 3,100 D $ 41.91 ( 13 ) 1,050,818 I By the Zachary and Casey Lynch Living Trust dated February 24, 2009 ( 3 ) Common Stock 02/03/2021 S( 1 ) 1,512 D $ 43.1 ( 14 ) 1,049,306 I By the Zachary and Casey Lynch Living Trust dated February 24, 2009 ( 3 ) Common Stock 02/03/2021 S( 1 ) 1,900 D $ 44.22 ( 15 ) 1,047,406 I By the Zachary and Casey Lynch Living Trust dated February 24, 2009 ( 3 ) Common Stock 02/03/2021 S( 1 ) 8,032 D $ 45 ( 16 ) 1,039,374 I By the Zachary and Casey Lynch Living Trust dated February 24, 2009 ( 3 ) Common Stock 02/03/2021 S( 1 ) 600 D $ 45.73 ( 17 ) 1,038,774 I By the Zachary and Casey Lynch Living Trust dated February 24, 2009 ( 3 ) Common Stock 49,895 D Common Stock 91,911 I By The Casey C. Lynch 2019 Annuity Trust ( 18 )

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other Lynch Casey C/O CORTEXYME, INC. 269 EAST GRAND AVE. SOUTH SAN FRANCISCO, CA94080 X Chief Executive Officer Signatures /s/ Caryn Gordon McDowell, as Attorney-in-Fact for Casey C. Lynch 02/03/2021 Signature of Reporting Person Date

Explanation of Responses:

( 1 )The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 29, 2020. ( 2 )The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $34.15 to $35.14, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range. ( 3 )Casey C. Lynch is a trustee of the Zachary and Casey Lynch Living Trust dated February 24, 2009, and shares voting and dispositive power with one other trustee with respect to the shares held of record by the Zachary and Casey Lynch Living Trust dated February 24, 2009. ( 4 )The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $35.165 to $36.145, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range. ( 5 )The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $36.21 to $37.20, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range. ( 6 )The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $37.25 to $38.25, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range. ( 7 )The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $35.52 to $36.49, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range. ( 8 )The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $36.53 to $36.94, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range. ( 9 )The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $37.00 to $37.91, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range. ( 10 )The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $38.19 to $39.13, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range. ( 11 )The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $39.30 to $40.21, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range. ( 12 )The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $40.42 to $41.29, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range. ( 13 )The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $41.46 to $42.41, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range. ( 14 )The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $42.50 to $43.50, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range. ( 15 )The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $43.53 to $44.47, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range. ( 16 )The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $44.54 to $45.42, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range. ( 17 )The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $45.55 to $45.89, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range. ( 18 )Casey C. Lynch is the trustee of The Casey C. Lynch 2019 Annuity Trust, and holds sole voting and dispositive power with respect to the shares held of record by The Casey C. Lynch 2019 Annuity Trust.

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).

** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

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