Sec Form 4 Filing - Versant Venture Capital V, L.P. @ Crinetics Pharmaceuticals, Inc. - 2019-02-04

FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person Versant Venture Capital V, L.P. 2. Issuer Name and Ticker or Trading Symbol Crinetics Pharmaceuticals, Inc. [ CRNX] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director X __ 10% Owner _____ Officer (give title below) _____ Other (specify below) (Last) (First) (Middle) ONE SANSOME STREET, SUITE 3630 3. Date of Earliest Transaction (MM/DD/YY) 02/04/2019 (Street) SAN FRANCISCO, CA94104 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) _____ Form filed by One Reporting Person __ X __ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 02/04/2019 J( 1 ) 445,470 D $ 0 2,524,456 I See Footnote ( 2 ) Common Stock 02/04/2019 J( 3 ) 13,387 D $ 0 75,949 I See Footnote ( 4 ) Common Stock 02/04/2019 J( 5 ) 14,828 D $ 0 84,161 I See Footnote ( 6 ) Common Stock 02/04/2019 J( 7 ) 33,903 D $ 0 192,122 I See Footnote ( 8 ) Common Stock 02/04/2019 J( 9 ) 9,473 A $ 0 9,473 I See Footnote ( 10 ) Common Stock 02/04/2019 J( 11 ) 9,473 D $ 0 0 I See Footnote ( 10 ) Common Stock 02/04/2019 J( 12 ) 678 A $ 0 678 I See Footnote ( 13 ) Common Stock 02/04/2019 J( 14 ) 678 D $ 0 0 I See Footnote ( 13 )

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other Versant Venture Capital V, L.P. ONE SANSOME STREET, SUITE 3630 SAN FRANCISCO, CA94104 X Versant Affiliates Fund V, L.P. ONE SANSOME STREET, SUITE 3630 SAN FRANCISCO, CA94104 X Versant Ophthalmic Affiliates I, L.P. ONE SANSOME STREET, SUITE 3630 SAN FRANCISCO, CA94104 X Versant Venture Capital V (Canada), LP ONE SANSOME STREET, SUITE 3630 SAN FRANCISCO, CA94104 X Versant Ventures V, LLC ONE SANSOME STREET, SUITE 3630 SAN FRANCISCO, CA94104 X Versant Ventures V (Canada), L.P. ONE SANSOME STREET, SUITE 3630 SAN FRANCISCO, CA94104 X Signatures VERSANT VENTURE CAPITAL V, L.P. By: Versant Ventures V, LLC Its: General Partner By: /s/ Robin L. Praeger 02/06/2019 Signature of Reporting Person Date VERSANT AFFILIATES FUND V, L.P. By: Versant Ventures V, LLC Its: General Partner By: /s/ Robin L. Praeger 02/06/2019 Signature of Reporting Person Date VERSANT OPHTHALMIC AFFILIATES FUND I, L.P. By: Versant Ventures V, LLC Its: General Partner By: /s/ Robin L. Praeger 02/06/2019 Signature of Reporting Person Date VERSANT VENTURE CAPITAL V (CANADA) LP By: Versant Ventures V (Canada), L.P. Its: General Partner By: Versant Ventures V GP-GP (Canada), Inc. Its: General Partner By: /s/ Robin L. Praeger 02/06/2019 Signature of Reporting Person Date VERSANT VENTURES V, LLC By: /s/ Robin L. Praeger 02/06/2019 Signature of Reporting Person Date VERSANT VENTURES V (CANADA), L.P. By: Versant Ventures V GP-GP (Canada), Inc. Its: General Partner By: /s/ Robin L. Praeger 02/06/2019 Signature of Reporting Person Date

Explanation of Responses:

( 1 )Represents a pro-rata in-kind distribution of Common Stock of the Issuer by Versant Venture Capital V, L.P. ("VVC V") without consideration to its partners. ( 2 )These securities are held of record by VVC V. Versant Ventures V, LLC ("VV V") is the sole general partner of VVC V and may be deemed to have voting and investment power over the securities held by VVC V and as a result may be deemed to have beneficial ownership over such securities. Samuel D. Colella, William J. Link, Bradley Bolzon, Ph.D., Robin L. Praeger, Kirk G. Nielson and Thomas Woiwode, Ph.D. are managing directors of VV V and share voting and dispositive power over the shares held by VVC V; however, they each disclaim beneficial ownership of the shares held by VVC V, except to the extent of their pecuniary interests therein. ( 3 )Represents a pro-rata in-kind distribution of Common Stock of the Issuer by Versant Affiliates Fund V, L.P. ("VAF V") without consideration to its partners. ( 4 )These securities are held of record by VAF V. VV V is the sole general partner of VAF V and may be deemed to have voting and investment power over the securities held by VAF V and as a result may be deemed to have beneficial ownership over such securities. Samuel D. Colella, William J. Link, Bradley Bolzon, Ph.D., Robin L. Praeger, Kirk G. Nielson and Thomas Woiwode, Ph.D. are managing directors of VV V and share voting and dispositive power over the shares held by VAF V; however, they each disclaim beneficial ownership of the shares held by VAF V, except to the extent of their pecuniary interests therein. ( 5 )Represents a pro-rata in-kind distribution of Common Stock of the Issuer by Versant Ophthalmic Affiliates Fund I, L.P. ("VOA") without consideration to its partners. ( 6 )These securities are held of record by VOA. VV V is the sole general partner of VOA and may be deemed to have voting and investment power over the securities held by VOA and as a result may be deemed to have beneficial ownership over such securities. Samuel D. Colella, William J. Link, Bradley Bolzon, Ph.D., Robin L. Praeger, Kirk G. Nielson and Thomas Woiwode, Ph.D. are managing directors of VV V and share voting and dispositive power over the shares held by VOA; however, they each disclaim beneficial ownership of the shares held by VOA , except to the extent of their pecuniary interests therein. ( 7 )Represents a pro-rata in-kind distribution of Common Stock of the Issuer by Versant Venture Capital V (Canada) LP ("VVC CAN") without consideration to its partners. ( 8 )These securities are held of record by VVC CAN. Versant Ventures V GP-GP (Canada), Inc. ("VV V CAN GP") is the sole general partner of Versant Ventures V (Canada), L.P. ("VV V CAN") and VV V CAN is the sole general partner of VVC CAN. By virtue of such relationships, VV V CAN GP and VV V CAN may be deemed to have voting and investment power over the securities held by VVC CAN and as a result may be deemed to have beneficial ownership over such securities. Samuel D. Colella, William J. Link, Bradley Bolzon, Ph.D., Robin L. Praeger, Kirk G. Nielson and Thomas Woiwode, Ph.D. are directors of VV V CAN GP and share voting and dispositive power over the shares held by VVC CAN; however, they each disclaim beneficial ownership of the shares held by VVC CAN, except to the extent of their pecuniary interests therein. ( 9 )Represents a change in the form of ownership of VV V by virtue of the receipt of shares in the pro-rata in-kind distribution of Common Stock of the Issuer for no consideration by VVC V, VAF V and VOA. ( 10 )The shares are held VV V. ( 11 )Represents a pro-rata in-kind distribution of Common Stock of the Issuer by VV V without consideration to its members. ( 12 )Represents a change in the form of ownership of VV V CAN by virtue of the receipt of shares in the pro-rata in-kind distribution of Common Stock of the Issuer for no consideration by VVC CAN. ( 13 )The shares are held VV V CAN. ( 14 )Represents a pro-rata in-kind distribution of Common Stock of the Issuer by VV V CAN without consideration to its partners.

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* If the form is filed by more than one reporting person, see Instruction 4(b)(v).

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