Sec Form 4 Filing - Cirino Dennis @ SeaSpine Holdings Corp - 2023-01-05

FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person Cirino Dennis 2. Issuer Name and Ticker or Trading Symbol SeaSpine Holdings Corp [ SPNE] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director _____ 10% Owner X __ Officer (give title below) _____ Other (specify below) SVP, Global Spinal Systems (Last) (First) (Middle) 5770 ARMADA DRIVE 3. Date of Earliest Transaction (MM/DD/YY) 01/05/2023 (Street) CARLSBAD, CA92008 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) __ X __ Form filed by One Reporting Person _____ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 01/05/2023 D 48,556 D 0 D

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares Restricted Stock Units ( 2 ) 01/05/2023 D 11,804 ( 3 ) ( 3 ) Common Stock 11,804 ( 4 ) 0 D Restricted Stock Units ( 2 ) 01/05/2023 D 16,492 ( 5 ) ( 5 ) Common Stock 16,492 ( 6 ) 0 D Employee Stock Option (Right to Buy) $ 18.24 01/05/2023 D 34,211 ( 7 ) 01/01/2027 Common Stock 34,211 ( 8 ) 0 D Employee Stock Option (Right to Buy) $ 12.01 01/05/2023 D 53,518 ( 9 ) 01/01/2028 Common Stock 53,518 ( 10 ) 0 D Employee Stock Option (Right to Buy) $ 9.93 01/05/2023 D 5,845 ( 11 ) 04/23/2028 Common Stock 5,845 ( 12 ) 0 D Employee Stock Option (Right to Buy) $ 16.86 01/05/2023 D 19,652 ( 13 ) 01/28/2029 Common Stock 19,652 ( 14 ) 0 D Employee Stock Option (Right to Buy) $ 12.67 01/05/2023 D 41,229 ( 15 ) 02/28/2030 Common Stock 41,229 ( 16 ) 0 D Employee Stock Option (Right to Buy) $ 12.67 01/05/2023 D 20,619 ( 15 ) 02/28/2030 Common Stock 20,619 ( 17 ) 0 D

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other Cirino Dennis 5770 ARMADA DRIVE CARLSBAD, CA92008 SVP, Global Spinal Systems Signatures /s/ Paul Benny, Attorney-in-Fact for Dennis L. Cirino 01/09/2023 Signature of Reporting Person Date

Explanation of Responses:

( 1 )Disposed of pursuant to the Agreement and Plan of Merger by and among the issuer, SeaSpine Holdings Corporation, which became effective on January 5, 2023, in exchange for 20,213 Orthofix MedicalInc. ("Orthofix") ordinary shares having a market value of $22.76 per share at the effective time of the merger. ( 2 )Each restricted stock unit represents a contingent right to receive one share of SeaSpine Holdings Corporation common stock. ( 3 )The restricted stock units vest in three equal installments on each of January 28, 2022, 2023 and 2024. ( 4 )These restricted stock units were assumed by Orthofix in the merger and replaced by 4,914 Orthofix restricted stock units. ( 5 )The restricted stock units vest in three equal installments on each of February 28, 2023, 2024 and 2025. ( 6 )These restricted stock units were assumed by Orthofix in the merger and replaced by 6,865 Orthofix restricted stock units. ( 7 )The option vests as to 25% of the underlying shares on January 1, 2020 and the remaining 75% in twelve substantially equal quarterly installments thereafter. ( 8 )This option was assumed by Orthofix in the merger and replaced with an option to purchase 14,242 shares of Orthofix at a price of $43.82 per share. ( 9 )The option vests as to 25% of the underlying shares on January 1, 2021 and the remaining 75% in twelve substantially equal quarterly installments thereafter. ( 10 )This option was assumed by Orthofix in the merger and replaced with an option to purchase 22,279 shares of Orthofix at a price of $28.85 per share. ( 11 )The option fully vested and became exercisable on June 21, 2020. ( 12 )This option was assumed by Orthofix in the merger and replaced with an option to purchase 2,433 shares of Orthofix at a price of $23.86 per share. ( 13 )The option vests as to 25% of the underlying shares on January 28, 2022 and the remaining 75% in twelve substantially equal quarterly installments thereafter. ( 14 )This option was assumed by Orthofix in the merger and replaced with an option to purchase 8,181 shares of Orthofix at a price of $40.50 per share. ( 15 )The option vests as to 25% of the underlying shares on February 28, 2023 and the remaining 75% in twelve substantially equal quarterly installments thereafter. ( 16 )This option was assumed by Orthofix in the merger and replaced with an option to purchase 17,163 shares of Orthofix at a price of $30.44 per share. ( 17 )This option was assumed by Orthofix in the merger and replaced with an option to purchase 8,583 shares of Orthofix at a price of $36.04 per share.

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