Sec Form 4 Filing - COLUMN GROUP III, LP @ Revolution Medicines, Inc. - 2020-02-18

FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person COLUMN GROUP III, LP 2. Issuer Name and Ticker or Trading Symbol Revolution Medicines, Inc. [ RVMD] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director X __ 10% Owner _____ Officer (give title below) _____ Other (specify below) (Last) (First) (Middle) 1700 OWENS STREET, SUITE 500 3. Date of Earliest Transaction (MM/DD/YY) 02/18/2020 (Street) SAN FRANCISCO, CA94158 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) _____ Form filed by One Reporting Person __ X __ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 02/18/2020 C 7,977,384 A 7,977,384 D ( 2 ) ( 3 ) ( 4 ) ( 5 ) ( 6 )

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares Series A Preferred Stock ( 1 ) 02/18/2020 C 5,137,583 ( 1 ) ( 1 ) Common Stock 5,137,583 ( 7 ) $ 0 0 D Series B Preferred Stock ( 1 ) 02/18/2020 C 2,740,043 ( 1 ) ( 1 ) Common Stock 2,740,043 ( 8 ) $ 0 0 D Series C Preferred Stock ( 1 ) 02/18/2020 C 99,758 ( 1 ) ( 1 ) Common Stock 99,758 ( 9 ) $ 0 0 D

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other COLUMN GROUP III, LP 1700 OWENS STREET SUITE 500 SAN FRANCISCO, CA94158 X Svennilson Peter 1700 OWENS STREET SUITE 500 SAN FRANCISCO, CA94158 X Managing Partner COLUMN GROUP III-A, LP 1700 OWENS STREET SUITE 500 SAN FRANCISCO, CA94158 X COLUMN GROUP III GP, LP 1700 OWENS STREET SUITE 500 SAN FRANCISCO, CA94158 X General Partner PONOI CAPITAL, LP 1700 OWENS STREET SUITE 500 SAN FRANCISCO, CA94158 X Ponoi Capital II, LP 1700 OWENS STREET SUITE 500 SAN FRANCISCO, CA94158 X Ponoi Management, LLC 1700 OWENS STREET SUITE 500 SAN FRANCISCO, CA94158 X General Partner Ponoi II Management, LLC 1700 OWENS STREET SUITE 500 SAN FRANCISCO, CA94158 X General Partner GOEDDEL DAVID V 1700 OWENS STREET SUITE 500 SAN FRANCISCO, CA94158 X Managing Partner Kutzkey Tim 1700 OWENS STREET SUITE 500 SAN FRANCISCO, CA94158 X Managing Partner Signatures /s/ Jennifer J. Carlson, Attorney-in-fact 02/18/2020 Signature of Reporting Person Date

Explanation of Responses:

( 1 )The number of shares reflects a 1-for-4.8661 reverse stock split of the Issuer's common stock and preferred stock which became effective February 7, 2020. At the closing of the Issuer's initial public offering, each share of Series A Preferred Stock, Series B Preferred Stock and Series C Preferred Stock automatically converted into 1 share of the Issuer's common stock (on an adjusted basis, after giving effect to the 1-for-4.8661 reverse stock split) for no additional consideration. Shares of Series A Preferred Stock, Series B Preferred Stock and Series C Preferred Stock had no expiration date. ( 2 )The securities are directly held by The Column Group III, LP ("TCG III LP"), and indirectly held by The Column Group III GP, LP ("TCG III GP"), the general partner of TCG III LP. The managing partners of TCG III GP are David Goeddel, Peter Svennilson and Tim Kutzkey. The managing partners of TCG III GP may be deemed to have voting and investment power with respect to such shares. TCG III GP and each individual managing partner disclaims beneficial ownership of these shares, except to the extent of their respective pecuniary interest in such shares. ( 3 )The securities are directly held by The Column Group III-A, LP ("TCG III-A LP"), and indirectly held by TCG III GP, the general partner of TCG III-A LP. The managing partners of TCG III GP are David Goeddel, Peter Svennilson and Tim Kutzkey. The managing partners of TCG III GP may be deemed to have voting and investment power with respect to such shares. TCG III GP and each individual managing partner disclaims beneficial ownership of these shares, except to the extent of their respective pecuniary interest in such shares. ( 4 )The securities are directly held by Ponoi Capital II, LP ("Ponoi II LP"), and indirectly held by Ponoi II Management, LLC ("Ponoi II LLC"), the general partner of Ponoi II LP. The managing partners of Ponoi II LLC are David Goeddel, Peter Svennilson and Tim Kutzkey. The managing partners of Ponoi II LLC may be deemed to have voting and investment power with respect to such shares. Ponoi II LLC and each individual managing partner disclaims beneficial ownership of these shares, except to the extent of their respective pecuniary interest in such shares. ( 5 )The securities are directly held by Ponoi Capital, LP ("Ponoi LP"), and indirectly held by Ponoi Management, LLC ("Ponoi LLC"), the general partner of Ponoi LP. The managing partners of Ponoi LLC are David Goeddel, Peter Svennilson and Tim Kutzkey. The managing partners of Ponoi LLC may be deemed to have voting and investment power with respect to such shares. Ponoi LLC and each individual managing partner disclaims beneficial ownership of these shares, except to the extent of their respective pecuniary interest in such shares. ( 6 )Consists of 3,103,049 shares held directly by TCG III LP, 3,504,313 shares held directly by TCG III-A LP, 685,011 shares held directly by Ponoi LP and 685,011 shares held directly by Ponoi II LP. ( 7 )Consists of 2,412,789 shares held directly by TCG III LP and 2,724,794 shares held directly by TCG III-A LP. ( 8 )Consists of 643,410 shares held directly by TCG III LP, 726,611 shares held directly by TCG III-A LP, 685,011 shares held directly by Ponoi LP and 685,011 shares held directly by Ponoi II LP. ( 9 )Consists of 46,850 shares held directly by TCG III LP and 52,908 shares held directly by TCG III-A LP.

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).

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