Sec Form 4 Filing - Ross Edmund Burke Jr. @ AzurRx BioPharma, Inc. - 2018-12-27

FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person Ross Edmund Burke Jr. 2. Issuer Name and Ticker or Trading Symbol AzurRx BioPharma, Inc. [ AZRX] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director X __ 10% Owner _____ Officer (give title below) _____ Other (specify below) (Last) (First) (Middle) C/O JDJ FAMILY OFFICE SERVICES, PO BOX 962049 3. Date of Earliest Transaction (MM/DD/YY) 12/27/2018 (Street) BOSTON, MA02196 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) __ X __ Form filed by One Reporting Person _____ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 05/02/2018 P 20,000 ( 1 ) A $ 2.5 ( 1 ) 2,421,010 I See Footnote ( 2 ) Common Stock 12/27/2018 P 42,922 ( 1 ) A $ 1.18 ( 1 ) 2,463,932 I See Footnote ( 3 ) Common Stock 12/27/2018 P 23,200 ( 1 ) A $ 1.13 ( 1 ) 2,487,132 I See Footnote ( 3 ) Common Stock 12/28/2018 P 29,575 ( 1 ) A $ 1.18 ( 1 ) 2,516,707 I See Footnote ( 4 ) Common Stock 12/31/2018 P 23,848 ( 1 ) A $ 1.12 ( 1 ) 2,540,555 I See Footnote ( 5 )

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other Ross Edmund Burke Jr. C/O JDJ FAMILY OFFICE SERVICES PO BOX 962049 BOSTON, MA02196 X Signatures /s/ Edmund Burke Ross Jr. for himself and as manager of ADEC Private Equity Investment, LLC, as manager of EBR Ventures, LLC, and as manager of CEDA Investments, LLC 01/07/2019 Signature of Reporting Person Date

Explanation of Responses:

( 1 )Mr. Ross is the manager and holds sole voting and dispositive power over the shares of common stock and each of ADEC Private Equity Investment, LLC, EBR Ventures, LLC, and CEDA Investments, LLC disclaims beneficial ownership of such securities underlying the warrants, except to the extent of their respective pecuniary interest therein, if any, and this report shall not be deemed to be an admission that any of ADEC Private Equity Investment, LLC, EBR Ventures, LLC, or CEDA Investments, LLC is the beneficial owner of such securities for the purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose. Mr. Ross disclaims beneficial ownership of the securities described in this footnote except to the extent of his pecuniary interest. ( 2 )Of the aggregate number of shares purchased on May 2, 2018, CEDA Investments, LLC purchased all 20,000 shares. ( 3 )Of the aggregate number of shares purchased on December 27, 2018, EBR Ventures, LLC purchased all 66,122 shares. ( 4 )Of the aggregate number of shares purchased on December 28, 2018, EBR Ventures, LLC purchased all 29,575 shares. ( 5 )Of the aggregate number of shares purchased on December 31, 2018, EBR Ventures, LLC purchased all 23,848 shares.

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).

** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

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