Sec Form 4 Filing - CRANDELL KEITH @ Twist Bioscience Corp - 2020-12-07

FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person CRANDELL KEITH 2. Issuer Name and Ticker or Trading Symbol Twist Bioscience Corp [ TWST] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) X __ Director _____ 10% Owner _____ Officer (give title below) _____ Other (specify below) (Last) (First) (Middle) 8755 W. HIGGINS ROAD, SUITE 1025 3. Date of Earliest Transaction (MM/DD/YY) 12/07/2020 (Street) CHICAGO, IL60631 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) __ X __ Form filed by One Reporting Person _____ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 08/18/2020 J( 1 )( 5 ) 685,613 D $ 0 1,721,809 I By Arch Venture Fund VII, L.P. ( 2 ) ( 4 ) Common Stock 08/18/2020 J( 1 )( 5 ) 34,845 A $ 0 34,845 I By Keith L.Crandall Trust Common Stock 08/18/2020 J( 1 )( 5 ) 248,083 D $ 0 706,063 I By ARCH Venture Fund VIII Overage, L.P. ( 3 ) ( 4 ) Common Stock 08/18/2020 J( 1 )( 5 ) 3 A $ 0 34,848 I By Keith L.Crandall Trust Common Stock 09/02/2020 J( 1 )( 5 ) 497,032 D $ 0 1,224,777 I By Arch Venture Fund VII, L.P. ( 2 ) ( 4 ) Common Stock 09/02/2020 J( 1 )( 5 ) 25,261 A $ 0 60,109 I By Keith L.Crandall Trust Common Stock 09/02/2020 J( 1 )( 5 ) 220,641 D $ 0 485,422 I By ARCH Venture Fund VIII Overage, L.P. ( 3 ) ( 4 ) Common Stock 09/02/2020 J( 1 )( 5 ) 3 A $ 0 60,112 I By Keith L.Crandall Trust Common Stock 09/15/2020 J( 1 )( 5 ) 444,231 D $ 0 780,546 I By Arch Venture Fund VII, L.P. ( 2 ) ( 4 ) Common Stock 09/15/2020 J( 1 )( 5 ) 22,578 A $ 0 82,690 I By Keith L.Crandall Trust Common Stock 09/15/2020 J( 1 )( 5 ) 176,030 D $ 0 309,392 I By ARCH Venture Fund VIII Overage, L.P. ( 3 ) ( 4 ) Common Stock 09/15/2020 J( 1 )( 5 ) 2 A $ 0 82,692 I By Keith L.Crandall Trust Common Stock 12/07/2020 S 53,712 D $ 103.4 726,834 I By Arch Venture Fund VII, L.P. ( 2 ) ( 4 ) Common Stock 12/07/2020 S 21,288 D $ 103.4 288,104 I By ARCH Venture Fund VIII Overage, L.P. ( 3 ) ( 4 ) Common Stock 1,412 D

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other CRANDELL KEITH 8755 W. HIGGINS ROAD, SUITE 1025 CHICAGO, IL60631 X Signatures /s/ Mark Daniels, as Attorney-in-Fact for Keith Crandell 12/09/2020 Signature of Reporting Person Date

Explanation of Responses:

( 1 )Pro-rata distribution of Common Stock held by a limited partnership to its partners for no consideration. ( 2 )The shares are directly held by ARCH Venture Fund VII, L.P. ("ARCH Fund VII"). The sole general partner of ARCH Fund VII is ARCH Venture Partners VII, L.P. ("ARCH Partners VII"), which may be deemed to be the beneficial owner of the shares held by ARCH Fund VII. The sole general partner of ARCH Partners VII is ARCH Venture Partners VII, LLC ("ARCH VII LLC"), which may be deemed to be the beneficial owner of the shares held by ARCH Fund VII. ARCH Partners VII and ARCH VII LLC disclaim beneficial ownership of such shares, except to the extent of any pecuniary interest therein. ( 3 )The shares are directly held by ARCH Venture Fund VIII Overage, L.P. ("ARCH Overage"). The sole general partner of ARCH Overage is ARCH Venture Partners VIII, LLC ("AVP GPLLC"), which may be deemed to be the beneficial owner of the shares held by ARCH Overage. AVP GPLLC disclaims beneficial ownership of such shares, except to the extent of any pecuniary interest therein. ( 4 )Keith Crandell is a managing director of ARCH VII LLC and ARCH VIII LLC, and may be deemed to beneficially own the shares held by ARCH Fund VII and ARCH Overage. Mr. Crandell disclaims beneficial ownership of such shares, except to the extent of any pecuniary interest therein. ( 5 )Change in form of ownership of shares previously reported as beneficially owned by the reporting person.

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).

** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

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