Sec Form 4/A Filing - SC US (TTGP), LTD. @ Guardant Health, Inc. - 2018-10-09

FORM 4/A Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person SC US (TTGP), LTD. 2. Issuer Name and Ticker or Trading Symbol Guardant Health, Inc. [ GH] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director X __ 10% Owner _____ Officer (give title below) _____ Other (specify below) (Last) (First) (Middle) 2800 SAND HILL ROAD, SUITE 101 3. Date of Earliest Transaction (MM/DD/YY) 10/09/2018 (Street) MENLO PARK, CA94025 4. If Amendment, Date Original Filed (MM/DD/YY) 10/11/2018 6. Individual or Joint/Group Filing (Check Applicable Line) _____ Form filed by One Reporting Person __ X __ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price COMMON STOCK 10/09/2018 C 13,264 A 29,162 ( 2 ) I By Sandscape, LLC ( 3 ) COMMON STOCK 10/09/2018 C 5,564,701 A 5,564,701 I By Sequoia Capital USV XIV Holdco, Ltd. ( 4 ) COMMON STOCK 10/09/2018 C 1,402,994 A 1,402,994 I By Sequoia Capital USV XIV Holdco, Ltd. ( 4 ) COMMON STOCK 10/09/2018 C 233,832 A 233,832 I By Sequoia Capital USV XIV Holdco, Ltd. ( 4 ) COMMON STOCK 10/09/2018 C 508,497 A 508,497 I By Sequoia Capital USV XIV Holdco, Ltd. ( 4 ) COMMON STOCK 10/09/2018 C 44,866 A 44,866 I By Sequoia Capital USV XIV Holdco, Ltd. ( 4 )

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Da te (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares SERIES A PREFERRED STOCK ( 1 ) 10/09/2018 C 13,264 ( 1 ) ( 1 ) COMMON STOCK 13,264 ( 1 ) 0 I By Sandscape, LLC ( 3 ) SERIES A PREFERRED STOCK ( 1 ) 10/09/2018 C 5,564,701 ( 1 ) ( 1 ) COMMON STOCK 5,564,701 ( 1 ) 0 I By Sequoia Capital USV XIV Holdco, Ltd. ( 4 ) SERIES B PREFERRED STOCK ( 1 ) 10/09/2018 C 1,402,994 ( 1 ) ( 1 ) COMMON STOCK 1,402,994 ( 1 ) 0 I By Sequoia Capital USV XIV Holdco, Ltd. ( 4 ) SERIES C PREFERRED STOCK ( 1 ) 10/09/2018 C 233,832 ( 1 ) ( 1 ) COMMON STOCK 233,832 ( 1 ) 0 I By Sequoia Capital USV XIV Holdco, Ltd. ( 4 ) SERIES D PREFERRED STOCK ( 1 ) 10/09/2018 C 508,497 ( 1 ) ( 1 ) COMMON STOCK 508,497 ( 1 ) 0 I By Sequoia Capital USV XIV Holdco, Ltd. ( 4 ) SERIES E PREFERRED STOCK ( 1 ) 10/09/2018 C 44,866 ( 1 ) ( 1 ) COMMON STOCK 44,866 ( 1 ) 0 I By Sequoia Capital USV XIV Holdco, Ltd. ( 4 )

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other SC US (TTGP), LTD. 2800 SAND HILL ROAD SUITE 101 MENLO PARK, CA94025 X SC U.S. VENTURE 2010 MANAGEMENT, L.P. 2800 SAND HILL ROAD SUITE 101 MENLO PARK, CA94025 X SEQUOIA CAPITAL U.S. VENTURE 2010-SEED FUND, L.P. 2800 SAND HILL ROAD SUITE 101 MENLO PARK, CA94025 X SEQUOIA CAPITAL SCOUT FUND II, L.L.C. 2800 SAND HILL ROAD SUITE 101 MENLO PARK, CA94025 X Sandscape, LLC 2800 SAND HILL ROAD SUITE 101 MENLO PARK, CA94025 X SC U.S. VENTURE XIV MANAGEMENT, L.P. 2800 SAND HILL ROAD SUITE 101 MENLO PARK, CA94025 X SEQUOIA CAPITAL U.S. VENTURE FUND XIV, L.P. 2800 SAND HILL ROAD SUITE 101 MENLO PARK, CA94025 X SEQUOIA CAPITAL U.S. VENTURE PARTNERS FUND XIV, L.P. 2800 SAND HILL ROAD SUITE 101 MENLO PARK, CA94025 X SEQUOIA CAPITAL U.S. VENTURE PARTNERS FUND XIV (Q), L.P. 2800 SAND HILL ROAD SUITE 101 MENLO PARK, CA94025 X SEQUOIA CAPITAL USV XIV HOLDCO, LTD. 2800 SAND HILL ROAD SUITE 101 MENLO PARK, CA94025 X Signatures /s/ Jung Yeon Son, by power of attorney for Roelof F. Botha, a Director of SC US (TTGP), Ltd. 10/11/2018 Signature of Reporting Person Date /s/ Jung Yeon Son, by power of attorney for Roelof F. Botha, a Director of SC US (TTGP), Ltd., the general partner of SC US Venture 2010 Management, L.P. 10/11/2018 Signature of Reporting Person Date /s/ Jung Yeon Son, by power of attorney for Roelof F. Botha, a Director of SC US (TTGP), Ltd., the general partner of SC US Venture 2010 Management, L.P., the general partner of Sequoia Capital U.S. Venture 2010-Seed Fund, L.P. 10/11/2018 Signature of Reporting Person Date * See remarks 10/11/2018 Signature of Reporting Person Date ** See remarks 10/11/2018 Signature of Reporting Person Date *** See remarks 10/11/2018 Signature of Reporting Person Date **** See remarks 10/11/2018 Signature of Reporting Person Date ***** See remarks 10/11/2018 Signature of Reporting Person Date ****** See remarks 10/11/2018 Signature of Reporting Person Date ******* See remarks 10/11/2018 Signature of Reporting Person Date

Explanation of Responses:

( 1 )The shares of Preferred Stock automatically converted into shares of the Issuer's Common Stock at the then-effective conversion rate for no additional consideration (subject to the payment of cash in lieu of any fractional shares in accordance with the Certificate of Incorporation) immediately prior to the consummation of the Issuer's initial public offering, and have no expiration date. ( 2 )This Form 4 is being amended to reflect the correct total number of shares of the Issuer's Common Stock held by Sandscape, LLC following the transactions reported herein. ( 3 )The shares are directly held by Sandscape, LLC. SC US (TTGP), Ltd. is the general partner of SC US Venture 2010 Management, L.P., which is the general partner of Sequoia Capital U.S. Venture 2010-Seed Fund, L.P., which is the managing member of Sequoia Capital Scout Fund II, L.L.C., which is the managing member of Sandscape, LLC. As a result, SC US (TTGP), Ltd. may be deemed to share voting and dispositive power with respect to the shares held by Sandscape, LLC. Each Reporting Person disclaims beneficial ownership of such shares except to the extent of his or its pecuniary interest therein, and the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of the reported securities for purposes of Section 16 or for any other purposes. ( 4 )The shares are directly held by Sequoia Capital USV XIV Holdco, Ltd., or SC USV XIV Holdco. SC US (TTGP), Ltd. is the general partner of SC U.S. Venture XIV Management, L.P., which is the general partner of each of Sequoia Capital U.S. Venture Fund XIV, L.P., Sequoia Capital U.S. Venture Partners Fund XIV, L.P. and Sequoia Capital U.S. Venture Partners Fund XIV (Q), L.P., or collectively, the SC USV XIV Funds. The SC USV XIV Funds together own 100% of the outstanding ordinary shares of SC USV XIV Holdco. As a result, SC US (TTGP), Ltd. may be deemed to share voting and dispositive power with respect to the shares held by SC USV XIV Holdco. Each Reporting Person disclaims beneficial ownership of such shares except to the extent of his or its pecuniary interest therein, and the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of the reported securities for purposes of Section 16 or for any other purposes.

Remarks: Exhibit 24.1 Power of Attorney for Roelof F. Botha */s/ Jung Yeon Son, by power of attorney for Roelof F. Botha, a Director of SC US (TTGP), Ltd., the general partner of SC US Venture 2010 Management, L.P., the general partner of Sequoia Capital U.S. Venture 2010-Seed Fund, L.P., the managing member of Sequoia Capital Scout Fund II, L.L.C. ** /s/ Jung Yeon Son, by power of attorney for Roelof F. Botha, a Director of SC US (TTGP), Ltd., the general partner of SC US Venture 2010 Management, L.P., the general partner of Sequoia Capital U.S. Venture 2010-Seed Fund, L.P., the managing member of Sequoia Capital Scout Fund II, L.L.C., the managing member of Sandscape, LLC *** /s/ Jung Yeon Son, by power of attorney for Roelof F. Botha, a Director of SC US (TTGP), Ltd., the general partner of SC U.S. Venture XIV Management, L.P. **** /s/ Jung Yeon Son, by power of attorney for Roelof F. Botha, a Director of SC US (TTGP), Ltd., the general partner of SC U.S. Venture XIV Management, L.P., the general partner of Sequoia Capital U.S. Venture Fund XIV, L.P. *****/s/ Jung Yeon Son, by power of attorney for Roelof F. Botha, a Director of SC US (TTGP), Ltd., the general partner of SC U.S. Venture XIV Management, L.P., the general partner of Sequoia Capital U.S. Venture Partners Fund XIV, L.P. ****** /s/ Jung Yeon Son, by power of attorney for Roelof F. Botha, a Director of SC US (TTGP), Ltd., the general partner of SC U.S. Venture XIV Management, L.P., the general partner of Sequoia Capital U.S. Venture Partners Fund XIV (Q), L.P. *******/s/ Jung Yeon Son, by power of attorney for Roelof F. Botha, a Director of SC US (TTGP), Ltd., the general partner of SC U.S. Venture XIV Management, L.P., the general partner of each of Sequoia Capital U.S. Venture Fund XIV, L.P., Sequoia Capital U.S. Venture Partners Fund XIV, L.P. and Sequoia Capital U.S. Venture Partners Fund XIV (Q), L.P., the 100% owners of Sequoia Capital USV XIV Holdco, Ltd.

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).

** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

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