Sec Form 3 Filing - Kalia Kumud @ Guardant Health, Inc. - 2022-05-01

FORM 3 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person Kalia Kumud 2. Issuer Name and Ticker or Trading Symbol Guardant Health, Inc. [ GH] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director _____ 10% Owner X __ Officer (give title below) _____ Other (specify below) Chief Information Officer (Last) (First) (Middle) 505 PENOBSCOT DR 3. Date of Earliest Transaction (MM/DD/YY) 05/01/2022 (Street) REDWOOD CITY, CA94063 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) __ X __ Form filed by One Reporting Person _____ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price COMMON STOCK 20,530 D

STOCK OPTION (RIGHT TO BUY) Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares RESTRICTED STOCK UNITS $ 0 ( 1 ) ( 2 ) COMMON STOCK 41,747 D $ 117.61 ( 3 ) 11/01/2031 COMMON STOCK 22,726 D STOCK OPTION (RIGHT TO BUY) $ 74 ( 4 ) 04/20/2030 COMMON STOCK 28,670 D

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other Kalia Kumud 505 PENOBSCOT DR REDWOOD CITY, CA94063 Chief Information Officer Signatures John Saia 05/11/2022 Signature of Reporting Person Date

Explanation of Responses:

( 1 )(1)The Restricted Stock Units consist of three grants totaling 41,747 shares outstanding as of May 1, 2022. The first grant was granted on April 20, 2020, of which 10,751 shares are outstanding and vests 25% annually commencing on January 7, 2020. The second grant was granted on September 11, 2020, of which 19,633 shares are outstanding and vests 25% annually commencing on September 9, 2020. The third grant was granted on November 2, 2021, of which 11,363 shares are outstanding, and vests 25% on the first anniversary and quarterly thereafter commencing on September 1, 2021. ( 2 )Not applicable to Restricted Stock Units. ( 3 )The stock option vests and becomes exercisable as to 25% of the shares on September 1, 2022, and then in equal monthly installments through September 1, 2025. ( 4 )The stock option vests and becomes exercisable as to 25% of the shares on January 7, 2021, and then in equal monthly installments through January 7, 2024.

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).

** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

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