Sec Form 4 Filing - Ferran Astorga Jeannette @ Zoetis Inc. - 2023-02-08

FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person Ferran Astorga Jeannette 2. Issuer Name and Ticker or Trading Symbol Zoetis Inc. [ ZTS] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director _____ 10% Owner X __ Officer (give title below) _____ Other (specify below) Executive Vice President (Last) (First) (Middle) C/O ZOETIS INC., 10 SYLVAN WAY 3. Date of Earliest Transaction (MM/DD/YY) 02/08/2023 (Street) PARSIPPANY, NJ07054 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) __ X __ Form filed by One Reporting Person _____ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares Restricted Stock Unit ( 1 ) ( 2 ) 02/08/2023 A 632 ( 3 ) ( 4 ) Common Stock 632 $ 0 632 D Restricted Stock Unit ( 5 ) ( 2 ) ( 6 ) ( 4 ) Common Stock 994.5946 994.5946 ( 7 ) D Stock Option ( 8 ) $ 162.07 02/08/2023 A 2,353 ( 9 ) ( 10 ) Common Stock 2,353 $ 0 2,353 D Stock Option ( 11 ) ( 12 ) ( 13 ) ( 10 ) Common Stock 4,057 4,057 ( 12 ) D

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other Ferran Astorga Jeannette C/O ZOETIS INC. 10 SYLVAN WAY PARSIPPANY, NJ07054 Executive Vice President Signatures /s/ Brenda Santuccio, as Attorney-in-Fact 02/10/2023 Signature of Reporting Person Date

Explanation of Responses:

( 1 )Represents restricted stock units granted pursuant to the Zoetis Inc. Amended and Restated 2013 Equity and Incentive Plan, and dividend equivalent units automatically issued thereon (each an "RSU" and collectively, "RSUs"). One-third of the RSUs vest and are settled in shares of Zoetis common stock on each of the first, second and third anniversaries of the date of grant, respectively, subject to the reporting person's continued service through such vesting date and subject to earlier vesting and settlement upon certain specific events. ( 2 )Each RSU represents a contingent right to receive one share of Zoetis Inc. common stock. ( 3 )One-third of each RSU will vest and be settled in shares of Zoetis Inc. common stock on the first, second and third anniversaries of the date of grant, subject to the reporting person's continued service through such vesting date and subject to earlier vesting and settlement upon certain specific events. ( 4 )Not applicable. ( 5 )Represents restricted stock units granted pursuant to the Zoetis Inc. 2013 Equity and Incentive Plan, and dividend equivalent units automatically issued thereon (each an "RSU" and collectively, "RSUs"). RSUs vest and are settled in shares of Zoetis common stock on the third anniversary of the date of grant, subject to the reporting person's continued service through such vesting date and subject to earlier vesting and settlement upon certain specific events. ( 6 )Each RSU will vest and be settled in shares of Zoetis Inc. common stock on the third anniversary of the date of grant, subject to the reporting person's continued service through such vesting date and subject toearlier vesting and settlement upon certain specific events. ( 7 )The RSUs vest as follows: 306.9417 RSUs will vest on September 30, 2023; 219.9408 RSUs will vest on February 10, 2024; and 467.7121 RSUs will vest on February 8, 2025. ( 8 )Stock options (right to buy Zoetis Inc. common stock) granted pursuant to the Zoetis Inc. Amended and Restated 2013 Equity and Incentive Plan. ( 9 )One-third of each option will vest on the first, second and third anniversaries of the date of grant. ( 10 )Each option expires on the tenth anniversary of the date of grant. ( 11 )Stock options (right to buy Zoetis Inc. common stock) granted pursuant to the Zoetis Inc. 2013 Equity and Incentive Plan. ( 12 )1,304 options granted September 30, 2020 at an exercise price of $165.37 per option; 925 options granted February 10, 2021 at an exercise price of $160.62 per option; and 1,828 options granted February 8, 2022 at an exercise price of $201.30 per option. ( 13 )Each option vests on the third anniversary of the date of grant.

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).

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