Sec Form 4 Filing - COLUMN GROUP L P @ Nurix Therapeutics, Inc. - 2021-05-07

FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person COLUMN GROUP L P 2. Issuer Name and Ticker or Trading Symbol Nurix Therapeutics, Inc. [ NRIX] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director X __ 10% Owner _____ Officer (give title below) _____ Other (specify below) (Last) (First) (Middle) 1700 OWENS STREET, SUITE 500 3. Date of Earliest Transaction (MM/DD/YY) 05/07/2021 (Street) SAN FRANCISCO, CA94158 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) _____ Form filed by One Reporting Person __ X __ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 05/05/2021 J( 1 ) 2,000,000 D $ 0 1,394,333 D ( 2 ) Common Stock 05/05/2021 J( 3 ) 438,338 A $ 0 438,338 I See Footnote ( 4 ) Common Stock 05/05/2021 J( 5 ) 10,307 A $ 0 10,307 I See Footnote ( 6 ) Common Stock 05/05/2021 J( 7 ) 10,307 A $ 0 10,307 I See Footnote ( 8 ) Common Stock 05/05/2021 J( 9 ) 10,307 A $ 0 10,307 I See Footnote ( 10 ) Common Stock 05/05/2021 J( 11 ) 438,338 D $ 0 0 I See Footnote ( 4 ) Common Stock 05/05/2021 J( 12 ) 105 ,874 A $ 0 116,181 I See Footnote ( 6 ) Common Stock 05/05/2021 J( 13 ) 111,247 A $ 0 121,554 I See Footnote ( 8 ) Common Stock 05/05/2021 J( 14 ) 30,347 A $ 0 40,654 I See Footnote ( 10 ) Common Stock 05/05/2021 J( 15 ) 1,000,000 D $ 0 989,000 I See Footnote ( 16 ) Common Stock 05/05/2021 J( 17 ) 49,689 A $ 0 49,689 I See Footnote ( 18 ) Common Stock 05/05/2021 J( 19 ) 49,689 D $ 0 0 I See Footnote ( 18 ) Common Stock 05/05/2021 J( 20 ) 17,829 A $ 0 134,010 I See Footnote ( 6 ) Common Stock 05/05/2021 J( 21 ) 17,829 A $ 0 139,383 I See Footnote ( 8 ) Common Stock 05/05/2021 J( 22 ) 7,752 A $ 0 48,406 I See Footnote ( 10 ) Common Stock 686,274 I See Footnote ( 23 ) Common Stock 686,274 I See Footnote ( 24 )

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other COLUMN GROUP L P 1700 OWENS STREET SUITE 500 SAN FRANCISCO, CA94158 X COLUMN GROUP GP, LP 1700 OWENS STREET SUITE 500 SAN FRANCISCO, CA94158 X COLUMN GROUP II, LP 1700 OWENS STREET SUITE 500 SAN FRANCISCO, CA94158 X Column Group II GP, LP 1700 OWENS STREET SUITE 500 SAN FRANCISCO, CA94158 X General Partner PONOI CAPITAL, LP 1700 OWENS STREET SUITE 500 SAN FRANCISCO, CA94158 X Ponoi Management, LLC 1700 OWENS STREET SUITE 500 SAN FRANCISCO, CA94158 X Ponoi II Management, LLC 1700 OWENS STREET SUITE 500 SAN FRANCISCO, CA94158 X Ponoi Capital II, LP 1700 OWENS STREET SUITE 500 SAN FRANCISCO, CA94158 X Kutzkey Tim 1700 OWENS STREET SUITE 500 SAN FRANCISCO, CA94158 X GOEDDEL DAVID V 1700 OWENS STREET SUITE 500 SAN FRANCISCO, CA94158 X Signatures /s/ James Evangelista, as Attorney-in-fact for David Goeddel 05/07/2021 Signature of Reporting Person Date /s/ James Evangelista, as Attorney-in-fact for Tim Kutzkey 05/07/2021 Signature of Reporting Person Date /s/ James Evangelista, as Attorney-in-fact for Ponoi Capital II LP 05/07/2021 Signature of Reporting Person Date /s/ James Evangelista, as Attorney-in-fact for Ponoi II Management LLC 05/07/2021 Signature of Reporting Person Date /s/ James Evangelista, as Attorney-in-fact for Ponoi Capital LP 05/07/2021 Signature of Reporting Person Date /s/ James Evangelista, as Attorney-in-fact for Ponoi Management LLC 05/07/2021 Signature of Reporting Person Date /s/ James Evangelista, as Attorney-in-fact for The Column Group II LP 05/07/2021 Signature of Reporting Person Date /s/ James Evangelista, as Attorney-in-fact for The Column Group II GP LP 05/07/2021 Signature of Reporting Person Date /s/ James Evangelista, as Attorney-in-fact for The Column Group LP 05/07/2021 Signature of Reporting Person Date /s/ James Evangelista, as Attorney-in-fact for The Column Group GP LP 05/07/2021 Signature of Reporting Person Date

Explanation of Responses:

( 1 )Represents a pro-rata distribution, and not a purchase or sale, without additional consideration by The Column Group, LP ("TCG LP") to its general and limited partners. ( 2 )The securities are directly held by TCG LP, and indirectly held by The Column Group GP, LP ("TCG GP"), the general partner of TCG LP. The managing partners of TCG GP are David Goeddel and Peter Svennilson (the "Managing Partners"). The Managing Partners may be deemed to have voting and investment power with respect to such shares. Each individual Managing Partner disclaims beneficial ownership of these shares, except to the extent of his pecuniary interest in such shares. ( 3 )Represents a change in the form of ownership of TCG GP by virtue of the receipt of shares as a result of the pro-rata in-kind distribution of common stock of the Issuer for no consideration by TCG LP. ( 4 )The securities are directly held by TCG GP. The Managing Partners may be deemed to share voting and investment power with respect to such shares. Each of the Managing Partners disclaim beneficial ownership of these shares, except to the extent of their respective pecuniary interest in such shares. ( 5 )Represents a change in the form of ownership of Peter Svennilson by virtue of the receipt of shares as a result of the pro-rata in-kind distribution of common stock of the Issuer for no consideration by TCG LP. ( 6 )The securities are directly held by Peter Svennilson ( 7 )Represents a change in the form of ownership of David Goeddel by virtue of the receipt of shares as a result of the pro-rata in-kind distribution of common stock of the Issuer for no consideration by TCG LP. ( 8 )The securities are directly held by David Goeddel. ( 9 )Represents a change in the form of ownership of Tim Kutzkey by virtue of the receipt of shares as a result of the pro-rata in-kind distribution of common stock of the Issuer for no consideration by TCG LP. ( 10 )The securities are directly held by Tim Kutzkey. ( 11 )Represents a pro-rata distribution, and not a purchase or sale, without additional consideration by TCG GP to its general and limited partners. ( 12 )Represents a change in the form of ownership of Peter Svennilson by virtue of the receipt of shares as a result of the pro-rata in-kind distribution of common stock of the Issuer for no consideration by TCG GP. ( 13 )Represents a change in the form of ownership of David Goeddel by virtue of the receipt of shares as a result of the pro-rata in-kind distribution of common stock of the Issuer for no consideration by TCG GP. ( 14 )Represents a change in the form of ownership of Tim Kutzkey by virtue of the receipt of shares as a result of the pro-rata in-kind distribution of common stock of the Issuer for no consideration by TCG GP. ( 15 )Represents a pro-rata distribution, and not a purchase or sale, without additional consideration by The Column Group II, LP ("TCG II LP") to its general and limited partners. ( 16 )The securities are directly held by TCG II LP, and indirectly held by The Column Group II GP, LP ("TCG II GP"), the general partner of TCG II LP. The managing partners of TCG II GP are the Managing Partners. The Managing Partners may be deemed to have voting and investment power with respect to such shares. Each individual Managing Partner disclaims beneficial ownership of these shares, except to the extent of his pecuniary interest in such shares. ( 17 )Represents a change in the form of ownership of TCG II GP by virtue of the receipt of shares as a result of the pro-rata in-kind distribution of common stock of the Issuer for no consideration by TCG II LP. ( 18 )The securities are directly held by TCG II GP. The Managing Partners may be deemed to share voting and investment power with respect to such shares. Each of the Managing Partners disclaim beneficial ownership of these shares, except to the extent of their respective pecuniary interest in such shares. ( 19 )Represents a pro-rata distribution, and not a purchase or sale, without additional consideration by TCG II GP to its general and limited partners. ( 20 )Represents a change in the form of ownership of Peter Svennilson by virtue of the receipt of shares as a result of the pro-rata in-kind distribution of common stock of the Issuer for no consideration by TCG II GP. ( 21 )Represents a change in the form of ownership of David Goeddel by virtue of the receipt of shares as a result of the pro-rata in-kind distribution of common stock of the Issuer for no consideration by TCG II GP. ( 22 )Represents a change in the form of ownership of Tim Kutzkey by virtue of the receipt of shares as a result of the pro-rata in-kind distribution of common stock of the Issuer for no consideration by TCG II GP. ( 23 )The securities are directly held by Ponoi Capital, LP ("Ponoi LP"), and indirectly held by Ponoi Management, LLC ("Ponoi LLC"), the general partner of Ponoi LP. The managing partners of Ponoi LLC are David Goeddel, Peter Svennilson and Tim Kutzkey. The managing partn ers of Ponoi LLC may be deemed to have voting and investment power with respect to such shares. Each individual managing partner disclaims beneficial ownership of these shares, except to the extent of his pecuniary interest in such shares. ( 24 )The securities are directly held by Ponoi Capital II, LP ("Ponoi II LP"), and indirectly held by Ponoi II Management, LLC ("Ponoi II LLC"), the general partner of Ponoi II LP. The managing partners of Ponoi II LLC are David Goeddel, Peter Svennilson and Tim Kutzkey. The managing partners of Ponoi II LLC may be deemed to have voting and investment power with respect to such shares. Each individual managing partner disclaims beneficial ownership of these shares, except to the extent of his pecuniary interest in such shares.

Remarks: Due to SEC restrictions on the number of reporting owners, this is Form 1 of 2.

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).

** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
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