Sec Form 4 Filing - Biehl James @ TYME TECHNOLOGIES, INC. - 2022-09-16

FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person Biehl James 2. Issuer Name and Ticker or Trading Symbol TYME TECHNOLOGIES, INC. [ TYME] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director _____ 10% Owner X __ Officer (give title below) _____ Other (specify below) Chief Legal Officer (Last) (First) (Middle) C/O TYME TECHNOLOGIES, INC., 1 PLUCKEMIN WAY - SUITE 103 3. Date of Earliest Transaction (MM/DD/YY) 09/16/2022 (Street) BEDMINSTER, NJ07921 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) __ X __ Form filed by One Reporting Person _____ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 09/16/2022 D 105,000 D 0 D Common Stock 09/16/2022 D 150 D 0 I See Footnote( 3 )

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares Employee Stock Option - Option to buy $ 2.42 09/16/2022 D 500,000 ( 4 ) 09/08/2028 Common Stock 500,000 ( 4 ) 0 D Employee Stock Option - Option to buy $ 1.56 09/16/2022 D 253,200 ( 5 ) 05/02/2029 Common Stock 253,200 ( 5 ) 0 D Employee Stock Option - Option to buy $ 1.39 09/16/2022 D 360,000 ( 6 ) 05/06/2030 Common Stock 360,000 ( 6 ) 0 D Employee Stock Option - Option to buy $ 1.43 09/16/2022 D 500,000 ( 7 ) 06/13/2031 Common Stock 500,000 ( 7 ) 0 D Employee Stock Option - Option to buy $ 0.32 09/16/2022 D 482,200 ( 8 ) 04/21/2032 Common Stock 482,200 ( 8 ) 0 D Employee Stock Option - Option to buy $ 2.95 09/16/2022 D 12,500 ( 9 ) 03/28/2027 Common Stock 12,500 ( 9 ) 0 D Employee Stock Option - Option to buy $ 2.95 09/16/2022 D 12,500 ( 10 ) 03/28/2027 Common Stock 12,500 ( 10 ) 0 D Employee Stock Option - Option to buy $ 2.9 09/16/2022 D 75,000 ( 11 ) 05/24/2028 Common Stock 75,000 ( 11 ) 0 D

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other Biehl James C/O TYME TECHNOLOGIES, INC. 1 PLUCKEMIN WAY - SUITE 103 BEDMINSTER, NJ07921 Chief Legal Officer Signatures By: /s/ Richard Cunningham as attorney-in-fact for James Biehl 09/16/2022 Signature of Reporting Person Date

Explanation of Responses:

( 1 )Disposed of pursuant to the merger agreement between the issuer and Syros Pharmaceuticals, Inc. ("Syros") in exchange for 4,601 shares of Syros common stock having a market value of $7.30 per share at the close of trading on September 15, 2022, the last trading day immediately preceding the effective time of the merger, but after giving effect to a 1-for-10 reverse stock split by Syros (the "Reverse Split"), with cash paid in lieu of fractional shares. ( 2 )Disposed of pursuant to the merger agreement between the issuer and Syros in exchange for 6 shares of Syros common stock after giving effect to the Reverse Split, with cash paid in lieu of fractional shares. ( 3 )150 shares are owned by Mr. Biehl's spouse. ( 4 )This option was fully vested and assumed by Syros in the merger and replaced with an option to purchase 21,910 shares of Syros common stock for $55.23 per share, after giving effect to the Reverse Split. ( 5 )This option was fully vested and assumed by Syros in the merger and replaced with an option to purchase 11,095 shares of Syros common stock for $35.60 per share, after giving effect to the Reverse Split. ( 6 )This option was fully vested and assumed by Syros in the merger and replaced with an option to purchase 15,775 shares of Syros common stock for $31.72 per share, after giving effect to the Reverse Split. ( 7 )This option was fully vested and assumed by Syros in the merger and replaced with an option to purchase 21,910 shares of Syros common stock for $32.63 per share, after giving effect to the Reverse Split. ( 8 )This option was fully vested and assumed by Syros in the merger and replaced with an option to purchase 21,130 shares of Syros common stock for $7.30 per share, after giving effect to the Reverse Split. ( 9 )This option was fully vested and assumed by Syros in the merger and replaced with an option to purchase 547 shares of Syros common stock for $67.32 per share, after giving effect to the Reverse Split. ( 10 )This option was fully vested and assumed by Syros in the merger and replaced with an option to purchase 547 shares of Syros common stock for $67.32 per share, after giving effect to the Reverse Split. ( 11 )This option was fully vested and assumed by Syros in the merger and replaced with an option to purchase 3,286 shares of Syros common stock for $66.18 per share, after giving effect to the Reverse Split.

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).

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