Sec Form 4 Filing - Lightspeed Venture Partners Select IV, L.P. @ Personalis, Inc. - 2020-08-14

FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person Lightspeed Venture Partners Select IV, L.P. 2. Issuer Name and Ticker or Trading Symbol Personalis, Inc. [ PSNL] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director _____ 10% Owner _____ Officer (give title below) X __ Other (specify below) Affiliate of 10% Owner (Last) (First) (Middle) 2200 SAND HILL ROAD 3. Date of Earliest Transaction (MM/DD/YY) 08/14/2020 (Street) MENLO PARK, CA94025 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) _____ Form filed by One Reporting Person __ X __ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 08/14/2020 P 1,315,789 A $ 19 1,774,240 I ( 1 ) See footnote ( 1 ) Common Stock 4,117,768 I ( 2 ) See footnote ( 2 ) Common Stock 1,958,726 I ( 3 ) See footnote ( 3 )

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other Lightspeed Venture Partners Select IV, L.P. 2200 SAND HILL ROAD MENLO PARK, CA94025 Affiliate of 10% Owner Liew Jeremy 2200 SAND HILL ROAD MENLO PARK, CA94025 Affiliate of 10% Owner Mhatre Ravi 2200 SAND HILL ROAD MENLO PARK, CA94025 Affiliate of 10% Owner Lightspeed General Partner Select IV, L.P. 2200 SAND HILL ROAD MENLO PARK, CA94025 Affiliate of 10% Owner Lightspeed Ultimate General Partner Select IV, L.L.C. 2200 SAND HILL ROAD MENLO PARK, CA94025 Affiliate of 10% Owner Janmohamed Arif 2200 SAND HILL ROAD MENLO PARK, CA94025 Affiliate of 10% Owner Signatures LIGHTSPEED VENTURE PARTNERS SELECT IV, L.P. By: Lightspeed General Partner Select IV, L.P., its general partner By: Lightspeed Ultimate General Partner Select IV, L.L.C., its general partner By: /s/ Ravi Mhatre Duly Authorized Signatory 08/18/2020 Signature of Reporting Person Date /s/ Jeremy Liew 08/18/2020 Signature of Reporting Person Date /s/ Ravi Mhatre 08/18/2020 Signature of Reporting Person Date LIGHTSPEED GENERAL PARTNER SELECT IV, L.P. By: Lightspeed Ultimate General Partner Select, L.L.C., its general partner By: /s/ Ravi Mhatre Duly Authorized Signatory 08/18/2020 Signature of Reporting Person Date LIGHTSPEED ULTIMATE GENERAL PARTNER SELECT IV, L.L.C., By: /s/ Ravi Mhatre Duly Authorized Signatory 08/18/2020 Signature of Reporting Person Date /s/ Arif Janmohamed 08/18/2020 Signature of Reporting Person Date

Explanation of Responses:

( 1 )Shares held by Lightspeed Venture Partners Select IV, L.P. ("Lightspeed Select IV"). Lightspeed General Partner Select IV, L.P. ("LGP Select IV") is the general partner of Lightspeed Select IV. Lightspeed Ultimate General Partner Select IV, L.L.C. ("LUGP Select IV") is the general partner of LGP Select IV. Jeremy Liew, Ravi Mhatre and Arif Janmohamed are the managers of LUGP Select IV and share voting and dispositive power with respect to the shares held by Lightspeed Select IV. LGP Select IV, LUGP Select IV and Messrs. Liew, Mhatre and Janmohamed disclaim beneficial ownership of the shares held by Lightspeed Select IV except to the extent of their respective pecuniary interests therein. ( 2 )Shares held by Lightspeed Venture Partners VIII, L.P. ("Lightspeed VIII"). Lightspeed General Partner VIII, L.P ("LGP VIII") is the general partner of Lightspeed VIII. Lightspeed Ultimate General Partner VIII, Ltd. ("LUGP VIII") is the general partner of LGP VIII. Barry Eggers, Ravi Mhatre and Peter Nieh are the directors of LUGP VIII and share voting and dispositive power with respect to the shares held by Lightspeed VIII. LGP VIII, LUGP VIII and Messrs. Eggers, Mhatre and Nieh disclaim beneficial ownership of the shares held by Lightspeed VIII except to the extent of their respective pecuniary interests therein. ( 3 )Shares held by Lightspeed Venture Partners Select, L.P. ("Lightspeed Select"). Lightspeed General Partner Select, L.P ("LGP Select") is the general partner of Lightspeed Select. Lightspeed Ultimate General Partner Select, Ltd. ("LUGP Select") is the general partner of LGP Select. Barry Eggers, Jeremy Liew, Ravi Mhatre and Peter Nieh are the directors of LUGP Select and share voting and dispositive power with respect to the shares held by Lightspeed Select. LGP Select, LUGP Select and Messrs. Eggers, Liew, Mhatre and Nieh disclaim beneficial ownership of the shares held by Lightspeed Select except to the extent of their respective pecuniary interests therein.

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).

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