Sec Form 4 Filing - Orlandi Cesare @ Lantheus Holdings, Inc. - 2019-07-08

FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person Orlandi Cesare 2. Issuer Name and Ticker or Trading Symbol Lantheus Holdings, Inc. [ LNTH] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director _____ 10% Owner X __ Officer (give title below) _____ Other (specify below) Chief Medical Officer (Last) (First) (Middle) C/O LANTHEUS HOLDINGS, INC., 331 TREBLE COVE ROAD 3. Date of Earliest Transaction (MM/DD/YY) 07/08/2019 (Street) NORTH BILLERICA, MA01862 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) __ X __ Form filed by One Reporting Person _____ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 07/08/2019 M( 1 ) 6,672 A $ 21.1 75,155 D Common Stock 07/08/2019 M( 1 ) 13,346 A $ 21.1 88,501 D Common Stock 07/08/2019 M( 1 ) 6,672 A $ 21.1 95,173 D Common Stock 07/08/2019 M( 1 ) 8,896 A $ 21.1 104,069 D Common Stock 07/08/2019 S( 1 ) 28,002 D $ 28.33 ( 2 ) 76,067 D Common Stock 07/08/2019 S( 1 ) 7,584 D $ 27.6 ( 3 ) 68,483 D

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares Stock Option (right to buy) $ 21.1 07/08/2019 M( 1 ) 6,672 06/25/2018 03/04/2023 Common Stock 6,672 $ 0 0 D Stock Option (right to buy) $ 21.1 07/08/2019 M( 1 ) 13,346 ( 4 ) 03/04/2023 Common Stock 13,346 $ 0 0 D Stock Option (right to buy) $ 21.1 07/08/2019 M( 1 ) 6,672 ( 5 ) 03/04/2023 Common Stock 6,672 $ 0 0 D Stock Option (right to buy) $ 18.66 07/08/2019 M( 1 ) 8,896 ( 6 ) 08/05/2023 Common Stock 8,896 $ 0 0 D

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other Orlandi Cesare C/O LANTHEUS HOLDINGS, INC. 331 TREBLE COVE ROAD NORTH BILLERICA, MA01862 Chief Medical Officer Signatures /s/ Michael P. Duffy, attorney-in-fact 07/10/2019 Signature of Reporting Person Date

Explanation of Responses:

( 1 )The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on June 7, 2019. ( 2 )The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $28.00 to $28.45, inclusive. The reporting person undertakes to provide to Lantheus Holdings, Inc. ("LNTH"), any security holder of LNTH or the staff of the Securities and Exchange Commission ("SEC"), upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (2) to this Form 4. ( 3 )The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $27.06 to $27.99, inclusive. The reporting person undertakes to provide to LNTH, any security holder of LNTH or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (3) to this Form 4. ( 4 )These options vested in four equal installments on March 4, 2014, 2015, 2016 and 2017. ( 5 )Options to purchase 13,345 shares of Common Stock were granted to the reporting person on March 4, 2013, which options were subject to vesting in up to four equal annual installments based upon the level of LNTH's satisfaction of certain performance criteria for each of fiscal years 2013, 2014, 2015 and 2016. A certain level of the performance criteria were satisfied for each of fiscal years 2013 and 2014, resulting in the partial vesting as to 6,672 shares of Common Stock. ( 6 )These options vested in four equal installments on August 5, 2014, 2015, 2016 and 2017.

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