Sec Form 4 Filing - FRATES JAMES M @ Alkermes plc. - 2019-09-13

FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person FRATES JAMES M 2. Issuer Name and Ticker or Trading Symbol Alkermes plc. [ ALKS] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director _____ 10% Owner X __ Officer (give title below) _____ Other (specify below) SVP, Alks Inc; CFO ALKS (Last) (First) (Middle) CONNAUGHT HOUSE, 1 BURLINGTON ROAD 3. Date of Earliest Transaction (MM/DD/YY) 09/13/2019 (Street) DUBLIN4 Ireland 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) __ X __ Form filed by One Reporting Person _____ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Ordinary Shares 12/15/2017 G V 2,000 D $ 0 38,256 ( 1 ) D Ordinary Shares 09/13/2019 M 20,000 A $ 11.74 58,256 D Ordinary Shares 4,000 I By Sons Ordinary Shares 1,669 I By 2018 GRAT No. 2 ( 2 ) Ordinary Shares 150,000 I By 2019 GRAT No. 1 ( 3 )

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares Employee Stock Option (Right to Buy) $ 11.74 09/13/2019 M 20,000 ( 4 ) 05/17/2020 Ordinary Shares 20,000 $ 0 21,983 D

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other FRATES JAMES M CONNAUGHT HOUSE 1 BURLINGTON ROAD DUBLIN4 Ireland SVP, Alks Inc; CFO ALKS Signatures /s/ Jennifer Baptiste, attorney-in-fact for James M. Frates 09/17/2019 Signature of Reporting Person Date

Explanation of Responses:

( 1 )Includes (a) 80,000 shares transferred to the Reporting Person on June 3, 2019 to satisfy an annuity payment from the Reporting Person's 2018 GRAT No. 1 (the James M. Frates Grantor Retained Annuity Trust dated February 22, 2018 and funded on February 23, 2018), and (b) 17,204 shares transferred to the Reporting Person on June 10, 2019 to satisfy an annuity payment from the Reporting Person's 2014 GRAT (the James M. Frates Grantor Retained Annuity Trust dated December 19, 2013 and funded on March 14, 2014), and (c) 43,331 shares transferred to the Reporting Person on June 11, 2019 to satisfy an annuity payment from the Reporting Person's 2018 GRAT No. 2 (the James M. Frates Grantor Retained Annuity Trust dated May 25, 2018 and funded on May 29, 2018), and excludes 150,000 shares previously owned directly, which were contributed on June 14, 2019 to the 2019 GRAT No. 1 (the James M. Frates 2019 Grantor Retained Annuity Trust No. 1 dated June 13, 2019), each of which transactions was exempt from the reporting obligations of Section 16 of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), by virtue of Rule 16a-13 promulgated thereunder. ( 2 )Shares held by the 2018 GRAT No. 2. The Reporting Person is a trustee and beneficiary of the 2018 GRAT No. 2 and may be deemed to hold voting and dispositive power with regard to the reported shares held by the 2018 GRAT No. 2. ( 3 )Shares held by the 2019 GRAT No. 1. The Reporting Person is a trustee and beneficiary of the 2019 GRAT No. 1 and may be deemed to hold voting and dispositive power with regard to the reported shares held by the 2019 GRAT No. 1. ( 4 )These options are fully vested in accordance with their terms.

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).

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