Sec Form 4 Filing - SCHULER JACK W @ SOLENO THERAPEUTICS INC - 2020-12-07

FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person SCHULER JACK W 2. Issuer Name and Ticker or Trading Symbol SOLENO THERAPEUTICS INC [ SLNO] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director X __ 10% Owner _____ Officer (give title below) _____ Other (specify below) (Last) (First) (Middle) 100 N. FIELD DRIVE, SUITE 360 3. Date of Earliest Transaction (MM/DD/YY) 12/07/2020 (Street) LAKE FOREST, IL60045 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) __ X __ Form filed by One Reporting Person _____ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 12/07/2020 S 65,782 D $ 1.9058 11,303,080 I See Footnote ( 1 ) Common Stock 12/08/2020 S 63,746 D $ 1.854 11,239,334 I See Footnote ( 1 ) Common Stock 12/30/2020 S 33,697 D $ 1.9522 11,205,637 I See Footnote ( 1 ) Common Stock 12/31/2020 S 520 D $ 1.9496 11,205,117 I See Footnote ( 1 ) Common Stock 12/31/2020 S 98,862 D $ 1.9036 11,106,255 I See Footnote ( 1 ) Common Stock 01/04/2021 S 102,000 D $ 1.9917 11,004,255 I See Footnote ( 1 ) Common Stock 01/19/2021 S 29,723 D $ 2.0549 10,974,532 I See Footnote ( 1 ) Common Stock 01/20/2021 S 20,277 D $ 2.0952 10,954,255 I See Footnote ( 1 ) Common Stock 01/21/2021 S 15,566 D $ 2.097 10,938,689 I See Footnote ( 1 ) Common Stock 01/22/2021 S 72,591 D $ 2.0883 10,866,098 I See Footnote ( 1 ) Common Stock 01/25/2021 S 12,818 D $ 2.0567 10,853,280 I See Footnote ( 1 ) Common Stock 01/26/2021 S 12,763 D $ 2.0535 10,840,517 I See Footnote ( 1 ) Common Stock 01/27/2021 S 100 D $ 2.05 10,840,417 I See Footnote ( 1 ) Common Stock 02/18/2021 S 258,300 D $ 2.9521 10,582,117 I See Footnote ( 1 ) Common Stock 02/25/2021 S 200 D $ 2.71 10,581,917 I See Footnote ( 1 ) Common Stock 04/08/2021 S 248,636 D $ 1.2098 10,333,281 I See Footnote ( 1 ) Common Stock 04/09/2021 S 250,000 D $ 1.2017 10,083,281 I See Footnote ( 1 ) Common Stock 04/28/2021 S 80,498 D $ 1.2555 10,002,783 I See Footnote ( 1 ) Common Stock 04/30/2021 S 5,625 D $ 1.25 9,997,158 I See Footnote ( 1 ) Common Stock 05/05/2021 S 248,115 D $ 1.1412 9,749,043 I See Footnote ( 1 ) Common Stock 05/18/2021 S 41,195 D $ 1.0306 9,707,848 I See Footnote ( 1 ) Common Stock 01/15/2021 S 35,231 D $ 2.1128 4,460,894 I See Footnote ( 2 ) Common Stock 02/03/2021 S 14,700 D $ 2.1301 4,446,194 I See Footnote ( 2 ) Common Stock 02/22/2021 S 700 D $ 2.9706 4,445,494 I See Footnote ( 2 ) Common Stock 03/04/2021 S 172,717 D $ 2.6203 4,272,777 I See Footnote ( 2 ) Common Stock 03/05/2021 S 187,985 D $ 2.67 4,084,792 I See Footnote ( 2 )

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other SCHULER JACK W 100 N. FIELD DRIVE, SUITE 360 LAKE FOREST, IL60045 X Signatures /s/ Jack W. Schuler 08/03/2021 Signature of Reporting Person Date

Explanation of Responses:

( 1 )The shares are held by the Jack W. Schuler Living Trust, for which the Reporting Person serves as Trustee. ( 2 )The shares are held by the Schuler Family Foundation, for which the Reporting Person serves as President.

Remarks: Certain transactions reported in this Form 4 are matchable under Section 16(b) of the Securities Exchange Act of 1934, as amended, with certain prior purchases of shares by the Schuler Living Trust. The Schuler Living Trust has disgorged to the Issuer, on a voluntary basis, the full amount of any recoverable profits.

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).

** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
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