Sec Form 4 Filing - CANADA PENSION PLAN INVESTMENT BOARD @ IQVIA HOLDINGS INC. - 2018-12-04

FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person CANADA PENSION PLAN INVESTMENT BOARD 2. Issuer Name and Ticker or Trading Symbol IQVIA HOLDINGS INC. [ IQV] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director X __ 10% Owner _____ Officer (give title below) _____ Other (specify below) (Last) (First) (Middle) ONE QUEEN STREET EAST, SUITE 2500 3. Date of Earliest Transaction (MM/DD/YY) 12/04/2018 (Street) TORONTO ONTARIO, A6M5C 2W5 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) _____ Form filed by One Reporting Person __ X __ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common stock, $0.001 par value per share 12/04/2018 S 1,582,194 D $ 123.72 4,342,572 I See Footnote ( 1 ) ( 2 ) Common stock, $0.001 par value per share 12/04/2018 S 1,582,194 D $ 123.72 1,569,600 D ( 3 )

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other CANADA PENSION PLAN INVESTMENT BOARD ONE QUEEN STREET EAST SUITE 2500 TORONTO ONTARIO, A6M5C 2W5 X CPP Investment Board Private Holdings, Inc. ONE QUEEN STREET EAST, SUITE 2500 TORONTO ONTARIO, A6M5C 2W5 X Signatures BY: /s/ Kathryn J. Daniels Name: Kathryn J. Daniels, Title: Managing Director, Head of Compliance, Legal of Canada Pension Plan Investment Board 12/04/2018 Signature of Reporting Person Date BY: /s/ Kathryn J. Daniels Name: Kathryn J. Daniels, Title: Authorized Signatory of CPP Investment Board Private Holdings, Inc. 12/04/2018 Signature of Reporting Person Date

Explanation of Responses:

( 1 )The disposed securities reported on this row reflect a disposition of indirect ownership by Canada Pension Plan Investment Board ("CPPIB") through its wholly-owned subsidiaries, CPP Investment Board Private Holdings Inc. ("PHI"), CPP Investment Board (USRE III) Inc. ("USRE III") and CPP Investment Board Private Holdings (3) Inc. ("PHI3"). The 1,582,194 shares of the issuer indirectly disposed of by CPPIB consist of 1,541,216 shares sold by PHI, 24,587 shares sold by USRE III, and 16,391 shares sold by PHI3. ( 2 )The 4,342,572 shares of the issuer reflected in this row as indirectly owned by CPPIB consist of (i) 4,335,972 shares of the issuer directly owned by PHI and (ii) 6,600 shares of the issuer directly owned by CPPIB MAP Cayman SPC ("MAP"), a wholly-owned subsidiary of CPPIB. PHI has no beneficial ownership over the 6,600 shares of the issuer held indirectly by CPPIB through MAP. USRE III and PHI3 ceased to hold any shares of the issuer as of immediately after the disposition reflected in this row. ( 3 )CPPIB directly owns 1,569,600 shares of the issuer and the disposed securities reported on this Form 4 do not include any securities of the issuer directly owned by CPPIB. PHI has no beneficial ownership over the issuer's securities that are directly owned by CPPIB.

Remarks: PHI is party to a Shareholders Agreement, dated as of May 3, 2016, by and among the issuer and certain shareholders of the issuer. Pursuant to such Shareholders Agreement, PHI and certain other shareholders of the issuer agreed, among other things, to vote their respective shares of the issuer's common stock in favor of certain individuals designated to the issuer's board of directors in accordance with the terms and conditions thereof. As a result of the Shareholders Agreement, the reporting persons may be deemed to be members of a group (the "Group") holding over 10% of the outstanding shares of common stock of the issuer for purposes of Section 13(d) of the Securities Exchange Act of 1934, as amended. Each reporting person disclaims beneficial ownership of any securities of the issuer owned by any member of the Group, other than the securities reported in Table I of this Form 4.

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).

** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

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