Sec Form 4 Filing - Smith Cynthia @ ZS Pharma, Inc. - 2015-12-17

FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person Smith Cynthia 2. Issuer Name and Ticker or Trading Symbol ZS Pharma, Inc. [ ZSPH] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director _____ 10% Owner X __ Officer (give title below) _____ Other (specify below) Chief Commercial Officer (Last) (First) (Middle) 1100 PARK PLACE, SUITE 300 3. Date of Earliest Transaction (MM/DD/YY) 12/17/2015 (Street) SAN MATEO, CA94403 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) __ X __ Form filed by One Reporting Person _____ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 12/17/2015 D 12,598 ( 1 ) D $ 90 0 D

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares Employee Stock Option (NQ) - 6/24/13 $ 2.1284 12/17/2015 D 185,230 06/24/2014 06/23/2023 Common Stock 185,230 $ 0 0 D Employee Stock Option (NQ) - 4/24/14 $ 10.9242 12/17/2015 D 5,504 04/24/2015 04/23/2024 Common Stock 5,504 $ 0 0 D Employee Stock Option (ISO) - 4/24/14 $ 10.9242 12/17/2015 D 20,520 04/24/2015 04/23/2024 Common Stock 20,520 $ 0 0 D Employee Stock Option (ISO) - 7/8/14 $ 27.16 12/17/2015 D 2,791 07/07/2015 07/06/2024 Common Stock 2,791 $ 0 0 D Employee Stock Option (NQ) - 7/8/14 $ 27.16 12/17/2015 D 30,246 07/07/2015 07/06/2024 Common Stock 30,246 $ 0 0 D Employee Stock Option (ISO) - 6/18/15 $ 55.57 12/17/2015 D 1,799 06/18/2016 06/17/2025 Common Stock 1,799 $ 0 0 D Employee Stock Option (NQ) - 6/18/15 $ 55.57 12/17/2015 D 15,076 06/18/2016 06/17/2025 Common Stock 15,076 $ 0 0 D

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other Smith Cynthia 1100 PARK PLACE, SUITE 300 SAN MATEO, CA94403 Chief Commercial Officer Signatures /s/ Cynthia Smith 12/21/2015 Signature of Reporting Person Date

Explanation of Responses:

( 1 )Includes 3,000 shares in the form of restricted stock units and 443 shares acquired under the Employee Stock Purchase Plan on December 9, 2015

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).

** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

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