Sec Form 3 Filing - Susan L. Lindquist Family Trust @ YUMANITY THERAPEUTICS, INC. - 2020-12-22

FORM 3 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person Susan L. Lindquist Family Trust 2. Issuer Name and Ticker or Trading Symbol YUMANITY THERAPEUTICS, INC. [ YMTX] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director X __ 10% Owner _____ Officer (give title below) _____ Other (specify below) (Last) (First) (Middle) C/O NANCY E. DEMPZE HEMENWAY & BARNES,, LLP, 75 STATE STREET 3. Date of Earliest Transaction (MM/DD/YY) 12/22/2020 (Street) BOSTON, MA02109 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) _____ Form filed by One Reporting Person __ X __ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 484,168 ( 1 ) ( 2 ) I See Footnote ( 3 ) Common Stock 230,170 ( 1 ) ( 4 ) I See Footnote ( 5 ) Common Stock 241,257 ( 1 ) ( 6 ) I See Footnote ( 7 ) Common Stock 228,966 ( 1 ) ( 8 ) I See Footnote ( 9 )

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficia lly Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares Warrant (Right to Buy) $ 24.05 02/08/2016( 10 ) 08/14/2025 Common Stock 6,038 ( 1 ) ( 11 ) I See Footnote ( 12 )

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other Susan L. Lindquist Family Trust C/O NANCY E. DEMPZE HEMENWAY & BARNES, LLP, 75 STATE STREET BOSTON, MA02109 X Susan L. Lindquist Exempt Marital Trust C/O NANCY E. DEMPZE HEMENWAY & BARNES, LLP, 75 STATE STREET BOSTON, MA02109 X Susan L. Lindquist Massachusetts Non-Exempt Marital Trust C/O NANCY E. DEMPZE HEMENWAY & BARNES, LLP, 75 STATE STREET BOSTON, MA02109 X Susan L. Lindquist Massachusetts Only Marital Trust C/O NANCY E. DEMPZE HEMENWAY & BARNES, LLP, 75 STATE STREET BOSTON, MA02109 X Signatures Susan L. Lindquist Family Trust, By: Nancy E. Dempze, Trustee /s/ Nancy E. Dempze 01/04/2021 Signature of Reporting Person Date Susan L. Lindquist Exempt Marital Trust, By: Nancy E. Dempze, Trustee /s/ Nancy E. Dempze 01/04/2021 Signature of Reporting Person Date Susan L. Lindquist Non-Exempt Marital Trust, By: Nancy E. Dempze, Trustee /s/ Nancy E. Dempze 01/04/2021 Signature of Reporting Person Date Susan L. Lindquist Massachusetts only Marital Trust, By: Nancy E. Dempze, Trustee /s/ Nancy E. Dempze 01/04/2021 Signature of Reporting Person Date

Explanation of Responses:

( 1 )On August 22, 2020, the Issuer (formerly known as Proteostasis Therapeutics, Inc.) entered into an Agreement and Plan of Merger and Reorganization, as amended on November 6, 2020, with Pangolin Merger Sub, Inc. ("Merger Sub"), Yumanity, Inc. (formerly known as Yumanity Therapeutics, Inc.) and Yumanity Holdings, LLC ("Holdings"). On December 22, 2020, Merger Sub was merged with and into Yumanity, Inc., with Yumanity, Inc. surviving as a wholly-owned subsidiary of the Issuer (the "Merger"). Immediately prior to the consummation of the Merger, Holdings was merged with and into Yumanity, Inc., with Yumanity, Inc. as the surviving entity. ( 2 )The shares were received in exchange for 2,296,358.67 shares of Yumanity, Inc. common stock in connection with the Merger. ( 3 )Shares held by Susan L. Lindquist Family Trust. All other reporting persons disclaim beneficial ownership of these shares except to the extent of its pecuniary interest therein, if any. ( 4 )The shares were received in exchange for 1,091,672 shares of Yumanity, Inc. common stock in connection with the Merger. ( 5 )Shares held by Susan L. Lindquist Exempt Marital Trust. All other reporting persons disclaim beneficial ownership of these shares except to the extent of its pecuniary interest therein, if any. ( 6 )The shares were received in exchange for 1,144,257 shares of Yumanity, Inc. common stock in connection with the Merger. ( 7 )Shares held by Susan L. Lindquist Non-Exempt Marital Trust. All other reporting persons disclaim beneficial ownership of these shares except to the extent of its pecuniary interest therein, if any. ( 8 )The shares were received in exchange for 1,085,965 shares of Yumanity, Inc. common stock in connection with the Merger. ( 9 )Shares held by Susan L. Lindquist Massachusetts only Marital Trust. All other reporting persons disclaim beneficial ownership of these shares except to the extent of its pecuniary interest therein, if any. ( 10 )The warrant is fully vested on the date exercisable. ( 11 )Received in the Merger in exchange for a warrant to purchase 28,642 shares of Yumanity, Inc. common stock for $5.069 per share. ( 12 )Warrants held by Susan L. Lindquist Family Trust. All other reporting persons disclaim beneficial ownership of these shares except to the extent of its pecuniary interest therein, if any.

Remarks: The reporting persons may be deemed to be in a "group" as that term is used in Rule 13d-5(b) of the Securities Exchange Act of 1934, as amended. Each of the reporting persons expressly disclaims such group status.

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).

** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

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